Synthesis and antibacterial activities of N-benzyl isatin-3-semicarbazones and hydrazones

Abstract

A series of N-benzylisatin-3-semicarbazones and hydrazones has been synthesized and their antibacterial activities evaluated. For SAR studies -NH-CO- group of semicarbazones has been replaced by OCH2- moiety. The findings of this paper indicate that N-benzylisatin derivatives could be potential chemotherapeutic agents. Compound with 3-Cl substituent is more active than standard drug trimethoprim.