Ethanolysis of 4- (N, N-dimethylaminomemylene)-2-aryl-2-oxazolin-5-ones with sodium ethoxide in ethanol at reflux temperature: Unusual formation of N-acyl-α-amino acids

Abstract

The ethanolysis of 4-(N, N - dimethylaminomethylene)-2-aryl-2-oxazolin-5-ones 1 with sodium ethoxide in ethanol at reflux temperature leads to the formation of N-acyl-α-amino acids 3. Further, the reaction of 4-hydroxymethylene-2-phenyl-2-oxazolin-5 one 4 with sodium ethoxide in ethanol at reflux temperature also gives product 3a. The plausible mechanism has been proposed.