Morita-Baylis-Hillman reaction of acrylamide with isatin derivatives

Abstract

The Morita-Baylis-Hillman reaction of acrylamide, as an activated alkene, has seen little development due to its low reactivity. We have developed the reaction using isatin derivatives with acrylamide, DABCO as a promoter and phenol as an additive in acetonitrile. The corresponding aza version with acrylate and acrylonitrile has also been developed resulting in high product yields. © 2014 Singh et al; licensee Beilstein-Institut. License and terms: see end of document.