Effect of some β-adrenoceptor blockers on gastric secretion and ulceration in shay rats

Abstract

A comparative study of the effect of β-adrenoceptor antagonists on basal gastric secretion was undertaken in pylorus ligated Wistar albino rats. All the three antagonists i.e. propranolol, LB46 and practolol showed a dose-dependent effect on gastric secretion and ulceration. Small doses increased the volume, total acid and chloride output and pepsin secretion along with an increase in the ulcer index. High doses of all the three drugs caused inhibition of acid, chloride, pepsin output and ulcer index.