Title:
Synthesis, biological evaluation and molecular modeling study of pyrazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents

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dc.contributor.authorAshish Kumar Tewari
dc.contributor.authorVed Prakash Singh
dc.contributor.authorPratima Yadav
dc.contributor.authorGarima Gupta
dc.contributor.authorAmit Singh
dc.contributor.authorRaj Kumar Goel
dc.contributor.authorPravin Shinde
dc.contributor.authorC. Gopi Mohan
dc.date.accessioned2026-02-07T06:02:48Z
dc.date.issued2014
dc.description.abstractA novel series of pyrazole derivatives were synthesized and evaluated in vivo for their anti-inflammatory activity in carrageenan-induced rat paw edema model. Among all compounds, 5a, and 5b showed comparable anti-inflammatory activity to Nimesulide, the standard drug taken for the studies. In silico (docking) studies were carried out to investigate the theoretical binding mode of the compounds to target the cyclooxygenase (COX-2) using Autodock 4.2. © 2014 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.bioorg.2014.05.004
dc.identifier.issn452068
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2014.05.004
dc.identifier.urihttps://dl.bhu.ac.in/bhuir/handle/123456789/26856
dc.publisherAcademic Press Inc.
dc.subjectCOX-2 inhibitors
dc.subjectDrug design
dc.subjectInflammation
dc.subjectMolecular modeling
dc.subjectPyrazole
dc.titleSynthesis, biological evaluation and molecular modeling study of pyrazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents
dc.typePublication
dspace.entity.typeArticle

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