Synthesis, antibacterial and antifungal activities of 2,4-diethyl-3,5- diarylimino-1,2,4-thiadiazolidines and related benzothiazolylguanidines

Abstract

A series of 2,4-diethyl-3,5-diarylimino-1,2,4-thiadiazolidines (1a-k) and 1-(benzothiazol-2-yl)-1,3-diethyl-4-aryl guanidines (2a-k) were evaluated for their antibacterial and antifungal activities. Substitution of p-ethoxy (1d) and p-chloro (1f, 2f) in the aryl ring resulted in most active compounds of the series in both activities.