Hyper-Eosinophilic Syndrome with Myocarditis after Inactivated SARS-CoV-2 Vaccination-A Case Study

Abstract

Introduction: COVID-19 vaccine-induced serious adverse reactions are rare. Hyper-eosinophilia syndrome with myocarditis has not been reported earlier following BBV152 vaccine administration. Case Presentation: A young man without any co-morbidities presented with persistent periorbital swelling along with itchy swelling over fingers, resting tachycardia, and exertional breathlessness following the first dose of an inactivated SARS-CoV-2 vaccine (BBV152, COVAXIN). On inves-tigation, the patient had elevated blood eosinophils (maximum 21.5% with an absolute eosinophil count of 2767/mm3) and myocarditis (Lake Louise Criteria). He was successfully treated with ster-oids and supportive treatment. Conclusion: This is the first reported case of hyper-eosinophilia syndrome after COVAXIN ad-ministration. Prior history of the allergic disease may be a predisposing factor in this case. Hyper-eosinophilia can present with variable symptoms. In the current case, myocarditis was present with persistent resting tachycardia and dyspnea. Steroid and antiallergic drugs may be successful for the treatment of vaccine-induced hyper-eosinophilia with myocarditis. Increased vigilance is needed for such adverse events. © 2023 Bentham Science Publishers.