Development of a creatinine sensor based on a molecularly imprinted polymer-modified sol-gel film on graphite electrode

Abstract

An electrochemical creatinine sensor based on a molecularly imprinted polymer (MIP)-modified sol-gel film on graphite electrode was developed. The surface coating of MIP over sol-gel was advantageous to obtain a porous film with outwardly exposed MIP cavities for unhindered selective rebinding of creatinine from aqueous and biological samples. A fast differential pulse, cathodic stripping voltammetric response of creatinine can be obtained after being preanodized the sensor in neutral medium containing appropriate amount of creatinine at +1.8 V versus SCE for 120 s. A linear response over creatinine concentration in the range of 1.23 to 100 mg mL-1 was exhibited with a detection limit of 0.37 mg mL-1 (S/N=3). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.