Homocysteine Metabolism Pathway Genes and Risk of Type 2 Diabetes Mellitus/Metabolic Disorders

Abstract

It became very important to assess the association of gene variants involved in homocysteine metabolism in susceptibility to metabolic disorders particularly type 2 diabetes mellitus, obesity, and other related traits. Whole-body inflammation is the major event of type 2 diabetes mellitus. Those people who are suffering from type 2 diabetes mellitus always suffer from the elevated level of cytokines in both age and sex groups. Several risk factors have been identified showing marked elevated levels of IL-1β, TNF-α, and hsCRP. The elevated level of pro-inflammatory cytokines produces high level of all the above inflammatory markers including other biological parameters. The present study is based on the investigation of various pro-inflammatory cytokines in different types of diabetes mellitus. Considering the various factors like age, sex, rural and urbal differences including dyslipidemia have shown strong correlation with hyperhomocysteinemia. The present study is a part of a comprehensive collaborative program between various institutions considering the ethnic variation and biochemical markers. © The Editor(s) (if applicable) and The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd. 2022.