Phage therapy: A reinvigorated treatment against multidrug-resistant bacteria

Abstract

ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) is an abbreviation for their names and a reference to their capacity to evade the effects of routinely used antibiotics through mechanisms that have evolved through time. Under the theme "Antibiotic resistance: no action today, no treatment tomorrow," the World Health Organization on World Health Day 2011 emphasized the challenges of antibiotic resistance. Bacteriophages are bacterium-infecting viruses that destroy bacteria without harming human cells. As a result, they're thought to be able to cure bacterial infections alone or with antibiotics. Bacteriophages have evolved unique proteins that stop specific cellular processes to dedicate bacterial host metabolism to phage replication over time. In this moment of rapid development of MDR (Multidrug Resistance) bacterial infections and a scarcity of novel antibiotics to tackle these pathogens, phage therapy might be a good alternative to antimicrobial chemotherapy and helpful in achieving good health and well-being that is Sustainable Development Goal (SDG). © 2022 Nova Science Publishers, Inc..