Clinical usefulness of a modified imunoelectrophoresis method for detection of myeloma immunoglobulins

Abstract

Immunoelectrophoresis is a clinically prevalent and sensitive technique used for isotyping of multiple myeloma. Immunoglobulin heavy and light chain types are known as potential biomarkers for the disease. In the present study, we used a modified immunoelectrophoresis method to detect the immunoglobulins of myeloma patients. Immunoglobulins of myeloma patients showed sharp precipitin bands while that of normal healthy subjects showed no characteristic bands of myeloma. The method proved to be rapid and cost effectivewith no loss of sensitivity for detection of precipitin bands corresponding to immunoglobulin heavy and light chains of myeloma patients. © 2011 Nova Science Publishers, Inc. All rights reserved.