Exploring the C-2 position of glycals: Structural insights and synthetic applications

Abstract

The chemistry of glycals and their derivatives has emerged as a hot topic in carbohydrate chemistry owing to their incredible applications in biological and medicinal chemistry. Annulated and C-2-branched sugars derived from glycal moiety and its derivative have received immense attention. Herein, we have incorporated the current advancement in the synthesis of 2-C-branched sugars and annulated sugars derived from glycals, 2-haloglycals, and 2-nitroglycals using various synthetic strategies, including C-H activation, 1,2-annulation, and cyclopropanation. © 2025 Bentham Science Publishers. All rights reserved.