Matrix metalloproteases as diagnostic and prognostic biomarkers in cancer

Abstract

Matrix metalloproteinases (MMPs) play a crucial role in the degradation and remodeling of the extracellular matrix. The role of MMPs in neoplastic cell invasion, metastasis and cancer progression has been studied extensively. There is a strong relationship between MMP overexpression, development of cancer, and clinical prognosis. Increased levels of one or more members of MMPs have been seen in the majority of malignancies. As a result, it has been anticipated that MMPs may act as both diagnostic and prognostic markers in cancer patients. Certain members of the MMP family have been confirmed as biomarkers of diverse human cancer types. MMPs and prognostic markers are two areas of cancer research that provide critical understanding of disease progression and patient outcomes. Their impact is widespread, from the management of metastatic disease to the early detection of cancer. Therefore, their clinical importance continues to propel advancements in precision medicine and cancer therapy. © 2025 Elsevier Inc. All rights are reserved including those for text and data mining AI training and similar technologies.