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    Effect of midazolam on addition to epidural 0.5% isobaric bupivacaine
    (2008) Saswata Bharati; Dinesh K. Singh
    Background: Midazolam, when added to intrathecal bupivacaine, has shown to potentiate the effect of bupivacaine. The aim of this study is to assess the effect of midazolam on onsf et & duration of sensorimotor blockade, when added to epidural bupivacaine. Patients & Methods: This double blind randomized study includes sixty patients of ASA Grade I and II aged 20-60 years and weighing 40-70 kilogram, presenting for lower abdominal and lower limb surgeries. Subjects were randomly allocated into two groups of 30 each Group B and Group BM; who received 1 ml of normal saline and 1 ml (5 mg/ml) of preservative free Midazolam respectively with 15 ml of 0.5% isobaric bupivacaine through epidural catheter. Patients were observed for onset of sensory and motor blockade, duration for two segment regression of sensory block, recovery of motor block and duration of analgesia. Mean blood pressure, heart rate, respiratory rate, oxygen saturation and sedation score were monitored. Results: Addition of midazolam to epidural bupivacaine shortened the onset time for both sensory and motor block and increased the duration of sensory as well as motor blockade which is statistically significant. The duration of analgesia was also increased significantly in Group BM patients. Patients who received midazolam became sedated for about one hour. There is no statistically significant difference present in haemodynamic and respiratory parameters between the groups. Conclusion: Adding 5 mg of preservative free midazolam to isobaric bupivacaine through epidural route shortens the onset time and increases the duration of sensorimotor blockade with postoperative analgesia.