Chakraborty N.Roy I.Kumar P.Singh S.Pathak R.Gautam V.Gautam H.K.2025-01-132025-01-13202419994923https://dl.bhu.ac.in/ir/handle/123456789/705Prussian blue nanoparticles (PBNPs) have gained significant attraction in the field of nanomedicine due to their excellent biocompatibility, potential for nanoscale production, exceptional photothermal conversion ability, and multi-enzyme mimicking capabilities. PBNPs have made considerable advancements in their application to biomedical fields. This review embarks with a comprehensive understanding of the physicochemical properties and chemical profiling of PB-based nanoparticles, discussing systematic approaches to tune their dimensions, shapes, and sizes, as well as their biomedical properties. Subsequently, the use of PB-based NPs in the biomedical sector is extensively discussed and categorized based on the various features of modified PBNPs, either in combination with drugs or their analogues. Finally, the article highlights the existing challenges associated with current studies and explores the latest developments in these rapidly evolving PB-based nanoplatforms and their therapeutic potentials. Overall, this review aims to deepen the understanding of PB-based NPs and provide crucial insights into their rational design in disease treatment. � 2024 by the authors.enanti-inflammatoryantibacterial agentsbiocompatibilityphotothermal effectsPrussian blue nanoparticleswound healingReview10.3390/pharmaceutics16121616