Synthesis of 1-aryl-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione and their latentiation products as antithyroidal agent

Mehrotra, S.Roychowdhury, P.K.Pandey, K.K.Srivastava, P.K.2025-04-192025-04-19199519763786https://dl.bhu.ac.in/ir/handle/123456789/101672Two new 1-aryl-2-benzylmercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thiones have been synthesized by known methods (Goerdeler et al., 1967). These triazines on treatment with thiourea as dealkylating agent, in acidic medium afforded the corresponding 1-aryl-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione whch on further reaction with different α, β-unsaturated carbonyl compounds and aryl-cyanamide hydrochloride afforded the related adducts. Some of these compounds show appreciable antithyroidal activity. © 1995 The Pharmaceutical Society of Korea.α,β-unsaturated carbonyl compoundsAntithyroidal activityAryl-cyanamide hydrochlorideMercaptotriazineTriazing thioneSynthesis of 1-aryl-2-mercapto-4-aryl-1,6-dihydro-1,3,5-triazine-6-thione and their latentiation products as antithyroidal agentArticlehttps://doi.org/10.1007/BF02976332