Priyadarshan A.Tripathi G.Singh A.K.Rajkhowa S.Kumar A.Tiwari V.K.2025-01-132025-01-13202422133461https://dl.bhu.ac.in/ir/handle/123456789/3524The development of synthetic methodologies to obtain a diverse range of heterocyclic scaffolds has been a very attractive area of research due to their vast therapeutic importance. Conventional approaches that require the use of organic solvents, which are generally flammable, toxic, and not eco-friendly, are replaced either with greener alternatives or by completely avoiding their use. In literature, several solvent-free methods have already been reported for the synthesis of vast varieties of organic compounds. This review focuses on the solvent-free methods developed for the synthesis of different types of nitrogen and oxygen heterocycles which have exhibited diverse therapeutic applications. � 2024 Bentham Science Publishers.engreener alternativesHeterocyclescaffoldssolvent freetherapeutic applicationstoxicReview10.2174/2213346110666230915163034