Singh, Rishi KantKumar, SanjayKumar, SandeepShukla, AlokKumar, NaveenPatel, Anand KumarYadav, Lokesh KumarKaushalendraAntiwal, MeeraAcharya, Arbind2025-01-282025-01-282023243205https://dl.bhu.ac.in/ir/handle/123456789/21529PKC? is a molecule with many functions that play an important role in cell survival and death to maintain cellular homeostasis. Alteration in the normal functioning of PKC? is responsible for the complicated etiology of many pathologies, including cancer, cardiovascular diseases, kidney complications, neurodegenerative diseases, diabetics, and many others. Several studies have been carried out over the years on this kinase's function, and regulation in normal physiology and pathological conditions. A lot of data with antithetical results have therefore accumulated over time to create a complex framework of physiological implications connected to the PKC? function that needs comprehensive elucidation. In light of this information, we critically analyze the multiple roles played by PKC? in basic cellular processes and their molecular mechanism during various pathological conditions. This review further discusses the current approaches to manipulating PKC? signaling amplitude in the patient's favour and proposed PKC? as a therapeutic target to reverse pathological states. � 2023 Elsevier Inc.enAutophagyCancerCardiac diseaseCell cycleKidney complicationsNeurodegenerative diseasePKC?Therapeutic targetReviewhttps://doi.org/10.1016/j.lfs.2023.121999