Mishra, KirtikaSingh, Bachcha2025-01-302025-01-3020212678292https://dl.bhu.ac.in/ir/handle/123456789/26287A ?-cyclodextrin (?-CD) inclusion complex containing L-cysteine (CYS) as a guest was prepared by freeze drying method. Formation of the inclusion complex was confirmed by powder X-ray diffraction pattern, Fourier-transform infrared spectroscopy, thermogravimetric analysis, differential scanning calorimetry and scanning electron microscopy. The interaction between CYS and ?-CD was also analysed by conductivity measurement in aqueous solution. Thereafter, we developed a liquid crystal (LC)-based sensor system to detect CYS in aqueous solution following the principle of competitive host�guest inclusion. Here the guests sodium dodecyl sulphate (SDS) and CYS compete for the same hydrophobic cavity of host ?-CD. The dark optical image observed by polarising optical microscope confirms that CYS forms inclusion complex with ?-CD leaving SDS free which aligns LCs homeotropically. The constructed LC-based sensor could detect CYS up to 30��M in aqueous solution. Moreover the practical approach of this system was validated by sensing CYS in human serum. � 2020 Informa UK Limited, trading as Taylor & Francis Group.inclusionL-cysteineliquid crystalsensor?-cyclodextrinArticlehttps://doi.org/10.1080/02678292.2020.1836275