Kumar, AbhaiSingh, SmitaSingh, Varun KumarChaurasia, Rameshwar Nath2025-01-272025-01-272022978-032385730-7; 978-032389800-3https://dl.bhu.ac.in/ir/handle/123456789/14669The invasion of tape worm Taenia solium in human from contaminated food, water, and uncooked meat leads to neurocysticercosis (NCC). The NCC is the neglected disease of central nervous system prevalent in lower income countries and disseminate in high-income countries due to migration, which is major cause of morbidity/mortality. The diagnosis is based on clinical history, computed tomography, magnetic resonance imaging brain imaging, and other immunological and serological tests, although these test have their own limitations and not specific to differentiate the different form of NCC pathogenesis. The worldwide prevalence of NCC is lacking, and proper studies are needed to estimate the global presence of NCC. The current chapter discusses the epidemiology, pathophysiology, diagnosis, treatment, and socioeconomic challenges in eradication of the disease. The role of chronic inflammation in host defense, cyst degeneration, and reabsorption is discussed. The update on current research in development of new screening tools based on immunological and molecular test for diagnosis of NCC, treatment, and randomized control trial for parenchymal and extraparenchymal NCC is emphasized. NCC is believed as main cause of acquired epilepsy, among clinical and social workers, differentiation in seizures on the basis on proper diagnostic methods and international guidelines could decrease stigmatization among public. Further, the role of national and international agencies and socioeconomic factors involved in the eradication of disease are reviewed. � 2023 Elsevier Inc. All rights reserved.Taenia soliumEpilepsyExtraparenchymal neurocysticercosisNeurocysticercosisParenchymal neurocysticercosisBook chapterhttps://doi.org/10.1016/B978-0-323-85730-7.00027-8