Sharma, AjayPandey, Satyendra Kumar2025-01-282025-01-28202314770520https://dl.bhu.ac.in/ir/handle/123456789/21328A novel, simple and metal-free tandem approach for synthesizing ?-substituted (E)-?,?-unsaturated aldehyde derivatives through acid-catalyzed epoxide rearrangement and organocatalyzed aldol condensation processes has been described. This transformation has a broad substrate scope under mild conditions, including epoxides and aldehydes containing diverse functional groups, resulting in moderate to high yields of the desired products. Eventually, large-scale reactions and the synthesis of some bioactive molecules are used to demonstrate the potential applicability of the developed method. � 2023 The Royal Society of ChemistryenArticlehttps://doi.org/10.1039/d3ob01750h