Singh, Sumit K.Kumar, SunilYadav, Mangal S.Bhattacharya, SubratoTiwari, Vinod K.2025-01-282025-01-282023397881https://dl.bhu.ac.in/ir/handle/123456789/22058This report describes a convenient method for the Cu(I)- catalyzed tandem synthesis of dihydrophenanthridinediones and substituted isoquinolinones with the assistance of efficient glycosyl 1,2,3-triazole-based pyridinamide ligands. The catalytic system effectively works for the coupling of N-substituted 2-halobenzamides with various active methylene compounds to form biologically relevant heterocyclic scaffolds in high to excellent yields. The consecutive path of the reaction including intermolecular C C cross-coupling followed by intramolecular cyclization efficiently takes place at low catalytic loading. These glycosyl triazole-appended pyridinamides were synthesized in good yields by a CuI/DIPEA-mediated regioselective CuAAC click reaction. The notable features of the method include low catalytic loading, the use of cost-effective and biocompatible ligands, high reaction yield, and easily accessible starting materials that make the protocol more versatile. � 2023 Georg Thieme Verlag. All rights reserved.encarbohydratescopper catalysiscross-couplingCuAAC click reactionglycohybridstriazolesArticlehttps://doi.org/10.1055/a-2157-9001