Shankar, ShivGupta, Bikram KumarSingh, Madhup KumarPandey, Arun RajDwivedi, VandanaSachan, Sumit2025-01-272025-01-27202216078322https://dl.bhu.ac.in/ir/handle/123456789/13713Background & objetives: Laparoscopic procedures are usually followed by postoperative pain of variable intensity. The pain occurs due to streching of the visceral organs and peritoneum. We compared the antinociceptive effect of intraperitoneal instillation of bupivacaine with a combination of bupivacaine and dexmedetomidine in laparoscopic surgery. We assessed the quality of analgesia, time to the first request of rescue analgesia and total analgesics required in the first 24 h. Methodology: After institutional ethical committee approval a total of 162 patients were selected, out of which 81 patients were allocated into two groups using table of randomization. Group B received 0.25 % bupivacaine 50 ml with 5 ml normal saline and Group BD received 0.25 % bupivacaine 50 ml plus dexmedetomidine 1 ?g/kg diluted in 5 ml of normal saline intraperitoneally. Results: We found a significant difference between mean VAS scores of the two groups in all time points (p < 0.05). There was significant difference between mean time to the first request for analgesia and the mean total dose for analgesic required (p < 0.05) in between both groups. Conclusion: We conclude that intraperitoneal instillation of dexmedetomidine 1 ?g kg in combination with bupivacaine 0.25% in elective laparoscopic cholecystectomy significantly reduces the postoperative pain and analgesic requirement in postoperative period when compared to bupivacaine 0.25% alone. � 2022 Faculty of Anaesthesia, Pain and Intensive Care, AFMS. All rights reserved.Anesthetics, Local / administration & dosageBupivacaineBupivacaine / administration & dosageCholecystectomy, Laparoscopic / adverse effectsDexmedetomidine, IntraperitonealPain MeasurementPain, Postoperative / diagnosisPain, Postoperative / etiologyPain, Postoperative / prevention & controlVisual analogue scaleArticlehttps://doi.org/10.35975/apic.v26i3.1909