Kumar, SandeepGaba, ShivamTewari, MallikaJain, Gaurav2025-01-282025-01-2820239722068https://dl.bhu.ac.in/ir/handle/123456789/22371Peutz-Jeghers syndrome (PJS) is a rare inherited autosomal dominant disease characterised by mucocutaneous pigmentation and multiple polyps in the gastrointestinal tract. In up to 25% of cases, there is no family history of PJS (sporadic cases). Acute intestinal intussusception due to multiple polyps is the most common complication of PJS. PJS is associated with cancers of the gastrointestinal tract and in other organs. Adenocarcinoma arising in hamartomatous polyps is heavily debated. A 23-year-old gentleman presented with sporadic PJS with recurrent ileal intussusceptions and multifocal well-differentiated adenocarcinomas arising in the background of hamartomatous polyps following hamartoma-dysplasia-carcinoma sequence, which is herein discussed. The hamartoma-dysplasia-carcinoma sequence is one of the pathways of carcinogenesis within hamartomatous polyps in PJS. � 2022, Association of Surgeons of India.enHamartoma-dysplasia-carcinoma sequenceHamartomatous polypPeutz-Jeghers syndromeRecurrent intussusceptionArticlehttps://doi.org/10.1007/s12262-022-03528-8