Mishra V.K.Tiwari G.Khanna A.Yadav Y.Sagar R.2025-01-132025-01-1320241434193Xhttps://dl.bhu.ac.in/ir/handle/123456789/2385A simple, environmentally benign and catalyst-free method for the synthesis of chirally enriched imidazo[1,2-a]pyrimidinone glycohybrids has been successfully developed. The protocol is based on a base-induced annulation of ?-iodo-pyranone with Michael addition of 2-aminopyrimidinones followed by intramolecular nucleophilic substitution reaction. The privilege of this method includes mild reaction conditions, eco-friendly solvent and a transition-metal-free approach. Moreover, using straightforward simple methods, this reaction method exhibits a broad range of substrate scope and remarkable tolerance toward various functional groups. � 2024 Wiley-VCH GmbH.en2-aminopyrimidinoneannulation reactionsglycohybridsimidazo-pyrimidinonesMichael additionArticle10.1002/ejoc.202301301