Prasad, Bhim BaliBanerjee, Shouri2025-03-042025-03-04200313815148https://dl.bhu.ac.in/ir/handle/123456789/88457A silica gel-bound molecularly imprinted polymer to oxazolone(s) exclusively derived from certain cephalosporins (cefaclor) and penicillins (amoxycillins and ampicillins) was prepared using ethylacetate as a porogen. This was used as a packing material for solid phase extraction in column chromatography. The high selectivity and the quantitative sorption of oxazolone at pH 7.5 and a flow rate of 5.0 ml min-1 in a long (13.0 cm) and wide bore (1.4 cm internal diameter) column have led to efficient clean-up, selective enrichment, and indirect differential pulse adsorptive stripping voltammetric measurement of the β-lactams in the form of corresponding oxazolones either in a larger volume of dilute aqueous systems or in the pharmaceutical formulations, without complications of complex matrices, excipients or column deterioration. © 2003 Elsevier Science B.V. All rights reserved.Column chromatographic separationsMolecularly imprinted polymer-modified silica gelSelective enrichmentStripping voltammetryβ-LactamsArticlehttps://doi.org/10.1016/S1381-5148(02)00225-0