Singh, JyotiSingh, AnupriyaSharma, VineetSingh, Tryambak DeoSingh, MeenakshiGarg, RuchikaSharma, RohitGautam, Dev Nath Singh2025-01-272025-01-2720222198641Xhttps://dl.bhu.ac.in/ir/handle/123456789/13119Purpose of Review: Ayurveda�is�an�ancient�Indian�medical�system�with�unique�approaches�for the treatment of various brain disorders. Ashtanga Ghrita, a cow Ghrita-based polyherbal classical formulation, has been well defined in ancient Ayurvedic texts Ashtanga Hridya to enhance speech, intellect, and memory. The formulation contains eight potent neuroprotective herbs along with clarified cow butter and milk. The review is aimed to come up with comprehensive scientific evidence regarding the plant ingredients of Ashtanga Ghrita so that it can be used for further clinical studies as well as to treat a variety of neurological diseases. Recent Findings: The plant ingredients have been practiced since ancient times for various disorders in India as well as worldwide. The plants contain various phytochemicals including terpenes, steroids, glycosides, flavonoids, alkaloids, amino acids, fatty acids, aryl esters, and carbohydrates. The collected pharmacological evidence suggests that all the plant ingredients have neuroprotective, anxiolytic, antidepressant, antioxidant, immunomodulatory, sedative, antiproliferative, and anticonvulsant activity. Summary: Based on the collected evidence, Ashtanga Ghrita may prove to be an effective neuroprotective drug and might be useful in various neurological disorders. Further, well-designed multicentric clinical trials are required to elucidate and comprehend the therapeutic potential of the formulation. � 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.Ashtanga GhritaAyurvedaCognitive disorderMedicated GhritaNeuroprotective activityReviewhttps://doi.org/10.1007/s40495-022-00300-0