Browsing by Author "B.L. Pandey"

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Anti-inflammatory activity of seed extracts of Pongamia pinnata in rat
(1996) R.K. Singh; B.L. Pandey
Pongamia pinnata is a marsh growing Indian tree. Its seeds are used in febrile and inflammatory diseases in Indian system of medicine. Previous preliminary studies with ethanolic seed extract of this plant had exhibited an anti-inflammatory effect in rat. Different solvent fractionated extracts were evaluated in the present study for anti-inflammatory effect in chemically induced paw inflammation in rats. Anti-inflammatory effects of P. pinnata were best seen against bradykinin and PGE1-induced inflammation. In contrast minimal effects were seen against histamine and 5-HT-induced inflammation. The predominant action of extracts of Pongamia pinnata appears to be a modulation of eicosanoid-events in inflammation.
Anti-inflammatory effect of (+)-pinitol
(2001) R.K. Singh; B.L. Pandey; M. Tripathi; V.B. Pandey
In the carrageenin-induced paw oedema in rats, (+)-pinitol (2.5-10 mg/kg, i.p.), isolated from Abies pindrow leaves, showed a significant anti-inflammatory effect, the highest dose being comparable to phenylbutazone (100 mg/kg, i.p.). Copyright © 2001 Elsevier Science B.V.
Cilostazol reduces inflammatory burden and oxidative stress in hypertensive type 2 diabetes mellitus patients
(2007) Neeraj K. Agrawal; Rituparna Maiti; D. Dash; B.L. Pandey
Objectives: Inflammation and oxidative stress cause genesis and progression of atherosclerosis in diabetes. This study aimed to assess effects of Cilostazol on these factors in hypertensive type 2 diabetic patients. Materials and methods: In randomized, open, add-on preventive controlled clinical trial design, 60 hypertensive type 2 diabetics aged ≥45 years were evaluated clinically and for total leukocyte count, erythrocyte sedimentation rate, serum albumin, serum hsC-reactive protein, plasma malondialdehyde, blood reduced glutathione and HbA1c levels. After informed consent, 30 patients received Cilostazol (100 mg) twice daily orally as add-on therapy. At 1 month follow-up, 26 patients in control group and 22 patients in Cilostazol group completed the trial and particular parameters were re-evaluated. Results: The mean age and duration of diabetes were 55 ± 7 years and 8 ± 6 years, respectively. At follow-up, the Cilostazol group showed significant (p < 0.001) decrease in hsC-reactive protein (23.6%), erythrocyte sedimentation rate (38.7%), total leukocyte count (12.6%), plasma malondialdehyde (17.6%), HbA1c (0.17%, p = 0.002) and increase in serum albumin (11.9%), blood reduced glutathione (3.5%) from baseline. UKPDS 10 years risk of coronary heart disease decreased by 6% (p = 0.002). The control group did not show significant improvement in inflammatory profile, oxidative status and HbA1c. Conclusion: Inflammatory and oxidative stress is high in hypertensive type 2 diabetic patients. Cilostazol reduces these factors as well as coronary heart disease risk in diabetes mellitus. © 2007 Elsevier Ltd. All rights reserved.
Drug utilization study and evaluation of anti-hypertensive prescriptions from medical reimbursement applications at university health care facility, BHU, Varanasi
(International Journal of Pharmacy and Pharmaceutical Science, 2015) Dev Priya; S. Purohit; B.L. Pandey
Objective: Pharmacoeconomics evaluates the relationship between clinical, economic, and humanistic outcome for maximizing the value for each monetary unit spent on product and services. So the objective of the study was to provide the option of pharmacoeconomic medications to the hypertensive patients thus saving the cost to the university as well as to its staff of lower economic strata. Methods: The prescriptions are generated at University Health Center along at the tertiary care center i.e. University hospital. Most often patients are prescribed medications of specific brands by the University hospital consultants, which are not available in the health center. The expenditure for self procured medication is subject to reimbursement by the University. The personal characteristics of patients like age, sex, department of treatment, diagnosis, duration of therapy, change in therapy etc. were noted. The exact formulation and manufacturer’s details were recorded. Retail cost of a particular drug available from different manufacturers in the same dose form, strength and quantity were also recorded wherever found appropriate. Results: Majority of patients were old and evenly bearing co-morbidity with hypertension. Judicious choice of common medicines may maximize the economical use of Institutional financial resources for the healthcare and economical expenditure for the patients as well without compromising the treatment of the disease thus fulfilling the objective. Conclusion: The therapy of hypertension with economical antihypertensive drugs or generic drugs may provide an economical option for the common people and reduced expenditure for the University. © 2015, International Journal of Pharmacy and Pharmaceutical Sciences. All Rights Reserved.
Effect of Pentoxifylline on inflammatory burden, oxidative stress and platelet aggregability in hypertensive type 2 diabetes mellitus patients
(2007) Rituparna Maiti; N.K. Agrawal; D. Dash; B.L. Pandey
Objectives: Inflammation and oxidative stress are main culprits behind atherosclerosis in diabetes mellitus. This study explores the effect of add-on Pentoxifylline on inflammatory burden and oxidative stress in hypertensive diabetic patients. Research design and methods: 60 hypertensive type 2 diabetic, aged ≥ 45 years were evaluated for anthropometry, clinical parameters, C-reactive protein, total leukocyte count, erythrocyte sedimentation rate, serum albumin, plasma malondialdehyde, blood reduced glutathione, platelet aggregation and clot retraction profile. With informed consent and randomization, Pentoxifylline (400 mg) was prescribed to 30 patients orally twice daily with meals as add-on therapy to the standard therapeutic regimen for one month. The particular parameters were repeated in 26 patients in control group and 25 patients in Pentoxifylline group who completed the follow up. The study was a randomized, open, add-on clinical trial with parallel controls. Results: At one-month follow-up, in the Pentoxifylline group, there was 20.9% decrease (p < 0.001) in C-reactive protein, 18% reduction (p < 0.001) in erythrocyte sedimentation rate, 11.1% reduction (p < 0.001) in total leukocyte count and 5.8% increase (p = 0.003) in serum albumin. Pentoxifylline showed 20.2% reduction in plasma malondialdehyde and 4.6% increase in blood reduced glutathione level. In therapeutic dose range, Pentoxifylline exerted a significant anti-aggregatory effect and a dose dependent decrease in clot retraction in-vitro but there was no significant change in ex-vivo clot retraction. The control group showed no statistically significant change in parameters assessed. Conclusion: This study reveals improvements in inflammatory markers, oxidative stress and platelet-aggregation by Pentoxifylline, thus preventing atherosclerosis in diabetes mellitus. © 2007 Elsevier Inc. All rights reserved.
Effect of Tectona grandis Linn. (common Teak tree) on experimental ulcers and gastric secretion
(1982) B.L. Pandey; R.K. Goel; N.K.R. Pathak; M. Biswas; P.K. Das
[No abstract available]
Effectiveness of vitiligo therapy in prospective observational study of 250 cases with review of consensus and individualized care perspective
(2013) A.K. Gupta; S.S. Pandey; B.L. Pandey
Patients and methods: Outcomes of six month therapy in 250 patients bearing varying disease profiles and treatment regimens delivered either in conformity or divergence from consensus guidelines were compared. Influence of trait variables of patients and disease on the outcomes was also examined. Results: Consensus approach yielded superior rates of repigmentation and improved quality of life. The latter effect significantly influenced the former. Therapy adhering guidelines did not yield optimal benefit in patients of younger age, with disease of shorter standing and involving resistant sites. Steroids best benefited the localized disease as topical monotherapy. Combination of steroid with photochemotherapy adhering guidelines benefited less in moderate disease extent. Steroid overtreatment in extensive disease compromised the prospects of repigmentation. Conclusions: Localized short duration disease may better be first treated with steroid-alternative immunosuppressants. Wider spread more than 3% body surface may also respond to their combination with steroids, prior applying photochemotherapy. Additive therapies are prudent with steroid/photochemotherapy than injudicious steroid overuse in progressive extensive disease. Strategies to counter steroid unresponsiveness and adverse effects, psychiatric address to stress, nutrient and environmental interventions deserve emphasis.
Further study of antiinflammatory effects of Abies pindrow
(1997) R.K. Singh; B.L. Pandey
Abies pindrow leaves are used as an Ayurvedic remedy for disorders with inflammatory symptoms. The antiinflammatory effect was established in preliminary studies. Fractional extraction of the leaves indicated uneven predominance of flavonoids, glycosides, terpenoids and steroids. An antiinflammatory effect in the 5 h carrageenin oedema model was exhibited by all fractions, indicating multiple active principles. Studies in granuloma pouch and adjuvant arthritis models in rats also indicated a significant antiinflammatory effect. The polar constituents were more inhibitory to acute, while non-polar ones prominently inhibited the chronic inflammatory reactions. No immunomodulatory effect could be indicated as such.
Immunopharmacological studies on Picrorhiza kurroa royle ex benth part VI: Effect on anaphylactic activation events in rat peritoneal mast cells
(1989) B.L. Pandey; P.K. Das; S.S. Gambhir
[No abstract available]
Immunopharmacological studies on picrorhiza kurroa royle-ex-benth part III: Adrenergic mechanisms of anti-inflammatory action
(1988) B.L. Pandey; P.K. Das
[No abstract available]
Immunopharmacological studies on Picrorhiza kurroa royle-ex-benth part IV: Cellular mechanisms of anti-inflammatory action
(1989) B.L. Pandey; P.K. Das
[No abstract available]
Immunopharmacological studies on picrorhiza kurroa royle-ex-benth part V: Anti-inflammatory action: Relation with cell types involved in inflammation
(1988) B.L. Pandey; P.K. Das
[No abstract available]
MicroRNAs and cardiovascular medicine
(SAGE Publications Ltd, 2014) Upinder Kaur; S.S. Chakrabarti; B.L. Pandey
MicroRNAs are non-coding RNA sequences that act as regulators of gene expression. They are aberrantly expressed in many pathological conditions. Cardiovascular diseases are among the leading causes of morbidity and mortality in the general population. Various knock-in and knockdown approaches have shown abnormal signature patterns of microRNAs in cardiovascular conditions like cardiac hypertrophy, myocardial infarction, heart failure, arrhythmias and vascular proliferative diseases. Since a single microRNA targets many genes, modulating a single microRNA involved in a disease carries a possible risk of undesirable side effects. The review focuses on current understanding of microRNAs in cardiovascular conditions, the possible underlying mechanisms and various approaches of modulating microRNAs. © The Author(s) 2014.
Pharmacovigilance in 150 cases of plaque psoriasis and a case for conventional therapy
(2012) A.K. Gupta; S.S. Pandey; B.L. Pandey
Psoriasis is commonest chronic skin disease afflicting 1-2% population and increasingly associating diabetic epidemic. The disfiguring stress, compromise of quality of life and uncertain response to therapy add risks of therapy getting distorted. Conventional medications remain popular with most physicians for treatment despite emergence of attractive biological therapies. Present study put vigil on the adverse consequences occurring in routine management of plaque psoriasis cases over three month uninterrupted treatment, excluding cases exhibiting noncompliance or dropouts. One fourth of all cases suffered one or more adverse effects stated in the report. Most adverse effects were explainable as known toxic effects of drugs or consequences of disease. The impact of therapeutic prescription in conformity with or in breach of standard guidelines, patient specific factors of age and sex, personal habits and diabetic co-morbidity were also assessed to comprehend scope for prevention, early detection or management of adverse effects. The literature is referred on available biological therapies as possible options and lacunae of evidence to their adoption are discussed. In balance, conventional drug therapy will continue to be mainstay of psoriasis therapy for forseable long period and quality care is suggested to best focus on minimizing their adverse effects.
Phytochemical screening, free radical scavenging, antimicrobial activity of ethanolic extract of Leptadenia pyrotechnica
(BRNSS Publication Hub, 2017) Shardendu Kumar Mishra; Dharmendra Kumar; Nidhi Pandey; Ragini Tilak; B.L. Pandey; Suresh Purohit
Background: Leptadenia pyrotechnica (LP) is a well-known traditional shrub used by the tribes of Africa and Asia. Locally, it is called as Khimp and recognized as therapeutic uses as well as animal fodder. Aims: The present study investigates the preliminary phytochemical contents, free radical scavenging, and antimicrobial activity against the bacterial and fungal strains of ethanolic extract and its fraction of LP (Decne.). Materials and Methods: Ethanolic extract and fractions of LP were used to different phytochemical qualitative screening methods to identify the constituents presented in it. Total flavonoids and total phenolic contents were determined to justify its antimicrobial activity. The antibacterial and antifungal activity of the extracts was measured by disc diffusion method, minimum inhibitory concentration, minimum bactericidal concentration, minimum fungicidal concentration, and zone of inhibition against the bacterial and fungal strains. 2, 2-diphenyl-1-picrylhydrazyl free radical scavenging activity had used to evaluate the in vitro antioxidant activity of extract and fractions. Results: Preliminary phytochemical screening of extract and fractions showed the presence of alkaloids, terpenoids, phenols, flavonoids, glycosides, saponins, tannins, and steroids. Reducing efficiency revealed dose-dependent inflation in concentration (6.25-200 μg/μL) with respect to quercetin and gallic acid. The presence of phenolic compounds, terpenoids, and flavonoids contribute to potent antimicrobial activity against bacterial and fungal strains. Conclusion: The present research work concluded the effectiveness of different extract and fractions at various concentrations against the bacterial and fungal strains. Free radical scavenging activity embarks its contribution as antimicrobial along with the presence of terpenoids, flavonoids, and phenolic residues.
Phytochemistry and pharmacological activity of Mucuna pruriens: A review
(BRNSS Publication Hub, 2017) Mukesh Kumar Yadav; Prabhat Upadhyay; Suresh Purohit; B.L. Pandey; Harish Shah
The plant Mucuna pruriens (Fabaceae) is an established herbal drug, widely known as "velvet bean," a vigorous annual climbing legume originally from Southern China and Eastern India, where it was at one time widely cultivated as a green vegetable crop. It has been shown that its seeds are potentially of substantial medicinal importance. The ancient Indian medical system, Ayurveda, traditionally used M. pruriens, even to treat such things as Parkinson's disease. M. pruriens has been shown to have antiparkinson and neuroprotective effects, which may be related to its antioxidant activity and used for the management of male infertility, nervous disorders, and also as an aphrodisiac.
The analgesic and anti-inflammatory activities of the hydroalcholic extract of "Shirishadi compound" in animal model
(2011) Divya Kajaria; J.S. Tripathi; S.K. Tiwari; B.L. Pandey
The main objective of the present investigation is to evaluate the anti-inflammatory & analgesic activity of ethanolic extract of Shirishadi polyherbal compound on rats. Shirishadi compound consist of three herbal drugs namely- Shirisha (Albizzia lebbeck), Nagarmotha (Cyprus rotandus) & Kantakari (Solanum xanthocarpum).In Ayurveda (ancient Indian system of medicine) all these herbs alone or in combination with other herbs are commonly used in the managmant of bronchial asthma. In the carrageenan-induced rat paw edema test for acute inflammation, the extract of Shirishadi compound in doses of 50mg, 200 mg and 500 mg/kg body weight showed 77% and 79% and 81% inhibition of edema, respectively, at the end of 4h which is comparable to that of standard ( endomethacin) i.e. 92%. In the acetic acid induced writhing test the extract of Shirishadi compound ( 200 and 500 mg/kg body weight) showed a significant (p<0.001) reduction in the number of writhes with 65.6% and 70.9% of inhibition, respectively. In radiant heat tail-flick test the crude extract produced 58.1% (p<0.001) and 61.1% (p<0.001) elongation of tail flicking time 30 minutes after oral doses of 200 and 500 mg/kg body weight respectively . After 60 minutes the extract showed 56.3% (p<0.001) and 59% (p<0.001) elongation of tail flicking time. Experimental results showed that Shirishadi compound has persuasive anti-inflammmatory property along with significant analgesic activity.
The effect of a traditional preparation of copper, tamrabhasma, on experimental ulcers and gastric secretion
(1982) A.K. Sanyal; B.L. Pandey; R.K. Goel
Use of a traditional preparation of copper, tamrabhasma, has been suggested in Ayurvedic texts for peptic ulcer. The anti-ulcerogenic effect of copper per se has not been reported in the literature. In the present study the anti-ulcerogenic effect of tamrabhasma was observed in 8-h immobilised, 4-h pylorus-ligated, and aspirin-induced gastric ulcers in rats. The anti-ulcerogenic effect of the drug was also studied in histamine-induced gastric and duodenal ulcers in male guinea pigs. The minimal oral effective anti-ulcerogenic dose of tamrabhasma has been determined to be 1 mg kg. The drug in this dose caused a decrease in the total acid and pepsin output and an increase in the carbohydrate/protein ratio, indicating increased mucus secretion in the gastric secretion of rats. Acute (1 g kg, orally) and sub-acute (100 mg kg, orally, for 7 days) toxicity studies did not show any toxicity including any histological or biochemical evidence of liver or kidney toxicity. The results of the present experimental studies thus lend credence to the suggested use of tamrabhasma in amplapitta, a condition resembling peptic ulcer. © 1982.