Browsing by Author "Dayamon David Mathew"

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Crosslinking of biomaterials
(Elsevier, 2024) Naveen Kumar; Anil Kumar Gangwar; Vineet Kumar; Dayamon David Mathew; Pawan Diwan Singh Raghuvanshi; Rahul Kumar Udehiya; Naresh Kumar Singh; Sangeeta Devi Khangembam; Sameer Shrivastava; Sonal Saxena; Rukmani Dewangan
Crosslinking of biomaterials is used to improve their properties for a variety of biomedical applications. For example, crosslinking can be used to improve the mechanical strength, stability, and durability of biomaterials. Crosslinking can also be used to control the release of drugs or other molecules from biomaterials. © 2025 Elsevier Inc. All rights reserved.
Decellularization and characterization methods
(Elsevier, 2024) Naveen Kumar; Vineet Kumar; Anil Kumar Gangwar; Sangeeta Devi Khangembam; Naresh Kumar Singh; Pawan Diwan Singh Raghuvanshi; Sameer Shrivastava; Sonal Saxena; Sangeetha P.; Rahul Kumar Udehiya; Dayamon David Mathew
An ideal biomaterial should initiate the minimal immune response possible and allow cellular infiltration while maintaining its structure and performing its intended function. Eventually, it will degrade and promote healthy tissue regeneration rather than fibrous scarring. The physiological similarity of the biomaterials is probably the most important factor governing their ability to obtain approval for use. Native extracellular matrices (ECMs) provoke a more natural healing response than synthetic materials, promoting cellular infiltration, proliferation, and differentiation into structures very similar to those of the uninjured host tissue. As previously discussed, many of the first ECM biomaterials were used in prostheses, providing structural support or mechanical functionality. Consequently, preservation of the original structure and strength while reducing immunogenicity was paramount. The most abundant protein in ECMs is collagen, a fibrous protein that is remarkably preserved across species and, therefore, invokes one of the weakest immune responses of all the proteins. This is, in fact, one reason natural collagen sutures implanted for thousands of years were so effective. Bovine collagen is still one of the most widely used and abundantly available xenogeneic materials used in biomedical applications. Even though it is so well preserved, xenogeneic collagen can still provoke immune reactions in humans who are hypersensitive to it or in extenuating circumstances. Typically, proper cleaning with detergents and terminal sterilization by gamma irradiation or ethylene oxide gas is enough to reduce the immune response to a very minimal level, lower even than synthetic meshes. © 2025 Elsevier Inc. All rights reserved.
Diaphragm-derived extracellular matrix scaffolds and clinical application
(Elsevier, 2024) Vineet Kumar; Naveen Kumar; Anil Kumar Gangwar; Kaarthick D.T.; Harendra Rathore; Swapan Kumar Maiti; Ashok Kumar Sharma; Dayamon David Mathew; Jetty Devarathnam; Sameer Shrivastava; Sonal Saxena; Apra Shahi; Himani Singh; Karam Pal Singh
Collagen is regarded as one of the most useful biomaterial due to its excellent biocompatibility, biodegradability, and weak antigenicity. In cellular grafts, the histocompatibility antigens of the cells cause immunological reaction phenomenon. Less immunogenicity and better tolerance of acellular grafts were observed in rats and rabbits. The need of the readily availability of a nonimmunogenic and nonprosthetic biomaterial that could guide the regeneration of normal tissue is a fascinating possibility. Acellular biological tissues have been proposed to be used as natural biomaterials for tissue repair. Natural biomaterials are composed of extracellular matrix proteins that are conserved and can be served as scaffolds for cell attachment, migration, and proliferation. The acellular matrix can stimulate exact regeneration of missing tissue. © 2025 Elsevier Inc. All rights reserved.
Fish swim bladder-derived tissue scaffolds
(Elsevier, 2024) Remya Vellachi; Naveen Kumar; Ashok Kumar Sharma; Sonal Saxena; Swapan Kumar Maiti; Vineet Kumar; Dayamon David Mathew; Sameer Shrivastava
Organ damage or loss can occur from congenital disorders, cancer, trauma, infection, inflammation, iatrogenic injuries, or other conditions and often necessitates reconstruction or replacement. Depending on the organ and severity of damage, autologous tissues can be used for reconstruction. However, there is unavailability of sufficient tissue and there is a degree of morbidity associated with the harvest procedure. For functional replacement, organ transplants are used for damaged tissues. However, there is a severe shortage of donor organs, which is worsening with the ageing of the population. Both aforementioned approaches rarely replace the entire function of the original organ. Tissues used for reconstruction can lead to complications because of their inherent divergent functional parameters. The replacement of deficient tissues with functionally equivalent tissues would improve the outcome for these patients. Therefore, engineered biological substitutes that can restore and maintain normal tissue function would be useful in tissue and organ replacement applications. © 2025 Elsevier Inc. All rights reserved.
Gall bladder-derived extracellular matrix scaffolds
(Elsevier, 2024) Naveen Kumar; Anil Kumar Gangwar; Sangeeta Devi Khangembam; Poonam Shakya; Ashok Kumar Sharma; Amit Kumar Sachan; Ravi Prakash Goyal; Parvez Ahmed; Kiranjeet Singh; Aswathy Gopinathan; Sonal Saxena; Sameer Shrivastava; Remya Vellachi; Dayamon David Mathew; Swapan Kumar Maiti; Karam Pal Singh
The extracellular matrix (ECM) with adequate bioactive molecules, capable of supporting the growth of cells participating in regeneration, is an ideal graft suitable for wound healing application. The ECM isolated from certain mammalian organs and tissues have been found to have these essential biocomponents that support cell proliferation, migration, and differentiation. These scaffolds are naturally rich in collagen, elastin, glycosaminoglycans, laminin, and fibronectin on which the cells can migrate, attach, and grow. In addition, many of the bioactive degradation products released from the graft at the site of the grafting mimic growth factors required for healing. The ECM is also known to aid angiogenesis by regulating the migration, proliferation, and sustenance of endothelial cells. Intact decellularized allogenic/xenogenic ECM has the necessary requisites to provide for initial requirements of repair and subsequent remodeling. Hence, ECM is correctly termed as nature’s ideal scaffold material. The decellularization specifically removes cellular components that give rise to a residual immunological response. These decellularization techniques include chemical, enzymatic, and mechanical means of removing cellular components, leaving a material composed essentially of ECM components. The decellularized tissues are expected to mimic closely the complex three-dimensional structure and mechanical properties of the native tissues from where it origins. One of the major goals in using natural biodegradable materials is to induce the host, to replace the implanted construct with native tissue. Cholecyst-derived ECM (CEM) recovered from ECM of porcine gall bladder had variable application in the field of regenerative medicine. This CEM found to be a novel acellular proteinaceous biodegradable biomaterial and may have potential applications as scaffolds in heart valve tissue engineering. This matrix is rich in collagen and contains several other macromolecules useful in tissue remodeling. © 2025 Elsevier Inc. All rights reserved.
Natural Biomaterials for Tissue Engineering
(Elsevier, 2024) Naveen Kumar; Sonal Saxena; Vineet Kumar; Anil Kumar Gangwar; Dayamon David Mathew; Sameer Shrivastava; Naresh Kumar Singh
Natural Biomaterials for Tissue Engineering is a comprehensive reference that provides in-depth principles for supporting and enabling knowledge during the tissue production process, focusing on different cell systems. The tissue fabrication process is illustrated with specific examples for more than 30 tissues, which may soon lead to new tissue engineering therapies. The section coverage includes an overall introduction, decellularization protocols specific to each tissue, characterization, materials and methods, cell seeding process, preclinical evaluation in laboratory animals, clinical applications, limitations, conclusion, and future challenges. Readers may turn to this up-to-date coverage for a widespread understanding of regenerative medicine, which will be useful to students and experts alike. © 2025 Elsevier Inc. All rights are reserved including those for text and data mining AI training and similar technologies.
Preface
(Elsevier, 2024) Naveen Kumar; Sonal Saxena; Vineet Kumar; Anil Kumar Gangwar; Dayamon David Mathew; Sameer Shrivastava; Naresh Kumar Singh
[No abstract available]
RETRIEVAL OF AN UNUSUAL FISHHOOK FOREIGN BODY FROM THE ESOPHAGUS IN A BUFFALO
(Kasetsart University, 2024) Rahul Kumar Udehiya; Dayamon David Mathew; Naresh Kumar Singh
A four-year-old female buffalo was presented with a complaint of accidental ingestion of fishhook along with fodder. The owner tried to pull out the fishhook thread during ingestion, accidentally the thread broke and, the fishhook was ingested by the buffalo. The clinical examination revealed hypersalivation and the animal was anxious to observe. Radiography on a standing animal revealed fishhook shape metallic opacity just below the 4 to 5th cervical vertebrae within the esophagus. The fishhook was removed manually without any surgical intervention with the help of the right hand under deep sedation. Recovery was uneventful and soon after the intervention the animal was observed to be almost back to normalcy. © 2024, Kasetsart University. All rights reserved.
Rumen-derived extracellular matrix scaffolds and clinical application
(Elsevier, 2024) Ajit Kumar Singh; Naveen Kumar; Pawan Diwan Singh Raghuvanshi; Harendra Rathore; Anil Kumar Gangwar; Sameer Shrivastava; Sonal Saxena; Mohar Singh; Dayamon David Mathew; Karam Pal Singh
The ruminant refers to a mammal having a stomach with four chambers. These include a forestomach, consists of a rumen, a reticulum and an omasum, and a fourth chamber known as an abomasum. Examples of ruminants include mammals belonging to the genus Copra, Bos, Cervus, and Ovis. The rumen underpins much of our agricultural industry. Without this stomach chamber, cows and other ruminants would be much less efficient at turning grass into milk, meat, and wool. A cow’s rumen has a capacity of up to 95 L and contains billions of bacteria and other microbes. These microbes produce the enzymes that digest cellulose into sugars and fatty acids for their hosts to use. A less desirable by-product is the potent greenhouse gas, methane; a single cow can produce up to 280 L of methane a day. Collectively, these organs occupy almost three-fourths of the abdominal cavity, filling virtually all of the left side and extending significantly into the right. The reticulum lies against the diaphragm and is joined to the rumen by a fold of tissue. The rumen is the largest of the forestomachs and is itself sacculated by muscular pillars into what are called the dorsal, ventral, caudodorsal, and caudoventral sacs. In many respects, the reticulum can be considered a “cranioventral sac” of the rumen; for example, ingesta flow freely between these two organs. The reticulum is connected to the spherical omasum by a short tunnel. The abomasum is the ruminant’s true or glandular stomach. © 2025 Elsevier Inc. All rights reserved.