Browsing by Author "G. DAS GUPTA"

Now showing 1 - 2 of 2

Effect of centrally administered prostaglandin D2 and some prostaglandin synthesis inhibitors on carrageenan‐induced paw oedema in rats
(1989) S.K. BHATTACHARYA; P. J. R. MOHAN RAO; G. DAS GUPTA
Abstract— The putative modulatory role of central prostaglandins (PGs) on peripheral inflammation has been explored by investigating the effects of intracerebroventricularly (i.c.v.) administered PGD2, the major rodent brain PG, hydrocortisone, a phospholipase A2 inhibitor, and the cyclo‐oxygenase inhibitors, paracetamol and mefenamic acid, on carrageenan‐induced paw inflammation in rats. PGD2 produced a dose‐related inflammation‐augmenting effect, whereas hydrocortisone and the PG synthesis inhibitors, paracetamol and mefenamic acid, induced attenuation of the peripheral oedema. These findings confirm an earlier report from this laboratory which had indicated that central PGs may modulate peripheral inflammation and that conventional anti‐inflammatory agents exert at least part of their effect by inhibiting central PG synthesis. 1989 Royal Pharmaceutical Society of Great Britain
Intracerebroventricularly administered bradykinin augments carrageenan‐induced paw oedema in rats
(1988) S.K. BHATTACHARYA; P. J. R. MOHAN RAO; NEETA DAS; G. DAS GUPTA
Abstract— Intracerebroventricular (i.e.v.) administered bradykinin (2.5 and 5.0 μg/rat) was found to augment carrageenan‐induced acute paw oedema throughout the 4 h post‐carrageenan observation period. The effect was statistically significant with the higher dose. The pro‐inflammatory effect of i.c.v. bradykinin was antagonized following pretreatment with hemicholinium and atropine ethoiodide administered i.c.v., drugs that reduce central cholinergic activity. Similarly, central administration of drugs that inhibit the synthesis of eicosanoids, hydrocortisone, diclofenac and paracetamol, also attenuated the pro‐inflammatory effect of bradykinin. The findings indicate that the inflammation‐promoting effect of centrally administered bradykinin involves the central prostaglandin and cholinergic neurotransmitter systems. 1988 Royal Pharmaceutical Society of Great Britain