Browsing by Author "Harendra Rathore"

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Diaphragm-derived extracellular matrix scaffolds and clinical application
(Elsevier, 2024) Vineet Kumar; Naveen Kumar; Anil Kumar Gangwar; Kaarthick D.T.; Harendra Rathore; Swapan Kumar Maiti; Ashok Kumar Sharma; Dayamon David Mathew; Jetty Devarathnam; Sameer Shrivastava; Sonal Saxena; Apra Shahi; Himani Singh; Karam Pal Singh
Collagen is regarded as one of the most useful biomaterial due to its excellent biocompatibility, biodegradability, and weak antigenicity. In cellular grafts, the histocompatibility antigens of the cells cause immunological reaction phenomenon. Less immunogenicity and better tolerance of acellular grafts were observed in rats and rabbits. The need of the readily availability of a nonimmunogenic and nonprosthetic biomaterial that could guide the regeneration of normal tissue is a fascinating possibility. Acellular biological tissues have been proposed to be used as natural biomaterials for tissue repair. Natural biomaterials are composed of extracellular matrix proteins that are conserved and can be served as scaffolds for cell attachment, migration, and proliferation. The acellular matrix can stimulate exact regeneration of missing tissue. © 2025 Elsevier Inc. All rights reserved.
Rumen-derived extracellular matrix scaffolds and clinical application
(Elsevier, 2024) Ajit Kumar Singh; Naveen Kumar; Pawan Diwan Singh Raghuvanshi; Harendra Rathore; Anil Kumar Gangwar; Sameer Shrivastava; Sonal Saxena; Mohar Singh; Dayamon David Mathew; Karam Pal Singh
The ruminant refers to a mammal having a stomach with four chambers. These include a forestomach, consists of a rumen, a reticulum and an omasum, and a fourth chamber known as an abomasum. Examples of ruminants include mammals belonging to the genus Copra, Bos, Cervus, and Ovis. The rumen underpins much of our agricultural industry. Without this stomach chamber, cows and other ruminants would be much less efficient at turning grass into milk, meat, and wool. A cow’s rumen has a capacity of up to 95 L and contains billions of bacteria and other microbes. These microbes produce the enzymes that digest cellulose into sugars and fatty acids for their hosts to use. A less desirable by-product is the potent greenhouse gas, methane; a single cow can produce up to 280 L of methane a day. Collectively, these organs occupy almost three-fourths of the abdominal cavity, filling virtually all of the left side and extending significantly into the right. The reticulum lies against the diaphragm and is joined to the rumen by a fold of tissue. The rumen is the largest of the forestomachs and is itself sacculated by muscular pillars into what are called the dorsal, ventral, caudodorsal, and caudoventral sacs. In many respects, the reticulum can be considered a “cranioventral sac” of the rumen; for example, ingesta flow freely between these two organs. The reticulum is connected to the spherical omasum by a short tunnel. The abomasum is the ruminant’s true or glandular stomach. © 2025 Elsevier Inc. All rights reserved.