Browsing by Author "Ibrahim Hussain"

Now showing 1 - 9 of 9

A comprehensive and critical narrative review on movement disorders linked through dengue virus based infection
(Springer-Verlag Italia s.r.l., 2025) Niraj Kumar Srivastava; Nikhil Pandey; Janki Makani; Ibrahim Hussain; Neetu Rani Dhiman; Anand Kumar; Deepika Srivastava Joshi
Background: Dengue virus (DENV) has emerged as a significant cause of neurological complications, including movement disorders, which fall under the broader category of neurological manifestations associated with DENV infection. These disorders can have serious implications for patient’s quality of life, especially in tropical and subtropical regions where dengue is endemic. The neurological complications of DENV, while less commonly recognized when compared to its classical features (like fever, haemorrhagic manifestations, or shock), are increasingly being reported thus warranting an exhaustive exploration. Methods: We undertook a comprehensive and critical review to investigate the emerging link between movement disorders and DENV infections. An in depth and broad range search was performed across leading scientific databases (PubMed, Scopus, Embase and Google Scholar). We collected and analyzed a wide spectrum of relevant studies and case reports. This detailed methodology ensured a systematic and authoritative exploration of the neurological consequences associated with DENV, creating the foundation for deeper clinical insight and future research. Results: The analysis encompassed 80 studies on movement disorders linked to DENV infections. These studies were thoroughly reviewed and critically evaluated, with the findings presented in an inclusive and investigative manner. Conclusion: This narrative review provides a comprehensive analysis of movement disorders linked to DENV infections, enveloping their epidemiology, clinical features, neuropathogenesis, current therapeutic strategies, and outlining extensive directions for future research. © Fondazione Società Italiana di Neurologia 2025.
A comprehensive expedition of tauopathies in subacute sclerosing panencephalitis (SSPE): a narrative review
(Springer Science and Business Media Deutschland GmbH, 2024) Nikhil Pandey; Niraj Kumar Srivastava; Anand Kumar; Ibrahim Hussain; Deepika Joshi
Introduction: Tauopathies are a class of neurodegenerative disorders characterized by the abnormal accumulation of hyperphosphorylated tau protein in the brain. Subacute sclerosing panencephalitis (SSPE) caused by a latent aberrant measles virus infection, is characterized by extensive inflammation and neuronal impairment. A prominent pathological hallmark of SSPE described recently is the accumulation of abnormal tau protein possibly resulting from diffuse brain inflammation triggered by measles virus infection. Short summary: Understanding the role of tau pathophysiology in SSPE is crucial for improving the diagnosis and management of this debilitating condition. Current research suggests that persistent measles virus infection in the brain leads to chronic inflammation, which in turn triggers abnormal tau phosphorylation and accumulation. Further elucidating the precise mechanisms linking measles virus infection, neuro-inflammation, and tauopathy in SSPE is essential for developing targeted therapies. Conclusion: This narrative review provides valuable insights for both researchers and clinicians in understanding the pathological mechanisms underlying SSPE which is crucial for developing effective treatment strategies. These might include antiviral drugs to combat persistent infection, anti-inflammatory agents to reduce neuro-inflammation, or even treatments targeting tau pathology directly. Collaborative efforts among researchers, clinicians, and public health authorities are crucial for advancing our understanding of SSPE to combat this devastating disorder. © The Author(s) 2024.
Clozapine for Parkinson’s disease psychosis in a septuagenarian: a nightmare turned into bliss
(Springer-Verlag Italia s.r.l., 2025) Janki Makani; Anand Kumar; Ibrahim Hussain; N. Suresh Kumar; Deepika Srivastava Joshi
Parkinson’s disease psychosis, characterized by confusion, visual hallucinations, and delusions is a nightmare for the patients and caregivers. Classic neuroleptics aggravate the motor symptoms, hence the need for an effective atypical antipsychotic. Currently Pimavanserin is the only approved drug for Parkinson’s disease psychosis (PDP), however it is not readily available. Clozapine with its excellent anti psychotic profile, without worsening of motor features, cost effectiveness and easy availability transcends all boundaries in improving the Quality of life in PD patients with psychosis. We describe an elderly patient with PDP with an excellent response to low dose clozapine. © Fondazione Società Italiana di Neurologia 2024.
Clozapine for Parkinson’s disease psychosis in a septuagenarian: a nightmare turned into bliss
(Springer-Verlag Italia s.r.l., 2024) Janki Makani; Anand Kumar; Ibrahim Hussain; Niraj Kumar; Deepika Joshi
Parkinson’s disease psychosis, characterized by confusion, visual hallucinations, and delusions is a nightmare for the patients and caregivers. Classic neuroleptics aggravate the motor symptoms, hence the need for an effective atypical antipsychotic. Currently Pimavanserin is the only approved drug for Parkinson’s disease psychosis (PDP), however it is not readily available. Clozapine with its excellent anti psychotic profile, without worsening of motor features, cost effectiveness and easy availability transcends all boundaries in improving the Quality of life in PD patients with psychosis. We describe an elderly patient with PDP with an excellent response to low dose clozapine. © Fondazione Società Italiana di Neurologia 2024.
Co-occurrence of Parkinson's disease and Retinitis Pigmentosa: A genetic and in silico analysis
(Elsevier Ltd, 2025) Archana Dwivedi; Anand Kumar; Mohammad D. Faruq; Varun Kumar Singh; Nidhi Dwivedi; Kamaljeet Singh; Ibrahim Hussain; Swati Parida; Gaurab Kumar Jha; N. Suresh Kumar; Deepika Srivastava Joshi
Introduction: Parkinson's disease (PD) is primarily driven by the protein Alpha Synuclein (A-Syn) accumulation. Synphilin-1 protein, encoded by the SNCAIP gene, which co-localizes with A-Syn is a known risk factor for PD. Retinitis pigmentosa (RP), is a cluster of retinal degenerative disorders, and Cyclic Nucleotide Gated channel subunit Alpha 1 (CNGA1) is one of the initial genes associated with RP. Patients with PD can have various kinds of visual dysfunction as a non-motor manifestation, but to date, CNGA1 mutation and RP as a PD associated visual symptom has not been reported. We report a mutation in the SNCAIP gene in a PD patient, not reported earlier, and its co-occurrence with RP-associated CNGA1 gene mutation. Method: Whole exome sequencing (WES) of the patient DNA sample and in-silico protein–protein interaction (PPI) analysis performed to find out proteins interacting with SNCAIP relevant concerning reported mutation of SNCAIP and further, CNGA1 interaction with SNCAIP. Result: We are reporting, a missense mutation (p.Thr64Ser) at the SNCAIP gene, co-occurring with a missense variation (p.Gly509Arg) in the CNGA1 gene. In silico PPI analysis suggests SIAH1 as an important protein affected by SNCAIP mutation. LGALS4 and SNCA (gene encoding A-Syn) are common interactors between SNCAIP and CNGA1. Conclusion: The current study has determined the co-occurrence of RP and PD, whole exome sequencing ascertains the mutations in SNCAIP and CNGA1 genes, which could be the cause of PD and RP co-occurrence. © 2024 International Brain Research Organization (IBRO)
Cumulative influence of immunogenic factors, genetic variations, and protein modulations in subacute sclerosing panencephalitis (SSPE): A narrative review
(John Wiley and Sons Inc, 2025) Nikhil Pandey; Niraj Kumar Srivastava; Anand Kumar; Ibrahim Hussain; Deepika Srivastava Joshi
Subacute sclerosing panencephalitis (SSPE) is a progressive and catastrophic neurodegenerative disorder due to persistent infection with the aberrant measles virus in the brain. The exact etiology of SSPE is still unknown, and early diagnosis remains a challenge, especially with the atypical presentations. The pathogenesis of SSPE involves a complex interplay between viral factors and immunological response of the host. The presenting review demonstrates an extensive glimpse of the immuno-genetics of SSPE, exploring the single-nucleotide polymorphisms (SNPs), genetic risk factors and immune responses that influence susceptibility and disease progression. © 2024 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd.
Cumulative influence of immunogenic factors, genetic variations, and protein modulations in subacute sclerosing panencephalitis (SSPE): A narrative review
(John Wiley and Sons Inc, 2024) Nikhil Pandey; Niraj Kumar Srivastava; Anand Kumar; Ibrahim Hussain; Deepika Joshi
Subacute sclerosing panencephalitis (SSPE) is a progressive and catastrophic neurodegenerative disorder due to persistent infection with the aberrant measles virus in the brain. The exact etiology of SSPE is still unknown, and early diagnosis remains a challenge, especially with the atypical presentations. The pathogenesis of SSPE involves a complex interplay between viral factors and immunological response of the host. The presenting review demonstrates an extensive glimpse of the immuno-genetics of SSPE, exploring the single-nucleotide polymorphisms (SNPs), genetic risk factors and immune responses that influence susceptibility and disease progression. © 2024 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd.
Dengue Fever Associated Opsoclonus Myoclonus Ataxia Syndrome
(John Wiley and Sons Inc, 2024) Anand Kumar; Ibrahim Hussain; Varun Kumar Singh; Deepika Joshi
[No abstract available]
Syncopal Seizure: A Rare Manifestation of Takayasu Arteritis
(Wolters Kluwer Medknow Publications, 2025) Anand Kumar; Ibrahim Hussain; Deepika Srivastava Joshi; Varun Kumar Singh
[No abstract available]