Browsing by Author "K.N. Agarwal"

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A comparative clinical study of saril and oral streptomycin in the treatment of diarrhoea in children
(1978) P.N. Singla; B.D. Bhatia; C.J. Singh; K.N. Agarwal
[No abstract available]
Acetylcholinesterase activity in developing rat brain during undernutrition
(1990) U.K. Singh; K.N. Agarwal
[No abstract available]
All India hospital post partum programme
(1981) K.N. Agarwal; B.D. Bhatia
[No abstract available]
Anaemia and mental functions in rural primary school children
(1989) D.K. Agarwal; S.K. Upadhyay; K.N. Agarwal; R.D. Singh; A.M. Tripathi
Mental functions of 388 (6-8 years of age) rural primary school children matched for social and educational status were assessed in relation to anaemia and nutritional status. Malin's intelligence scale for Indian children and an arithmetic test were administered to assess intelligence, attention and concentration. No significant differences were found between the IQ scores of anaemic and non-anaemic groups, except for the subtest digit span. In contrast, there was an effect of nutritinal status on IQ scores. Observations on the arithmetic test showed that anaemia is associated with lower levels of attention and concentration.
Biochemical changes in saliva of malnourished children
(1984) P.K. Agarwal; K.N. Agarwal; D.K. Agarwal
The protein concentration and activity of arginase enzymes in serum and saliva was estimated in a total of 94 children out of which 52 were suffering from protein-energy malnutrition (PEM) and 42 served as controls. The salivary ferritin was also estimated in 41 children (control eight and PEM 33). There was a progressive fall in serum and salivary arginase activity and levels of salivary protein and ferritin with severity of PEM. The salivary ferritin showed very significant fall even in PEM grade I. In PEM grade III the mean ferritin value was 3.28 ± 0.75 μg/L as compared to 169.3 ± 21.9 μg/L for normal children. The changes in salivary protein, arginase activity, and ferritin in PEM may be used in recognizing severity as well as early stage of the disease.
Birth Weight Patterns in Rural Undernourished Pregnant Women
(2002) S. Agarwal; A. Agarwal; A.K. Bansal; D.K. Agarwal; K.N. Agarwal
Objective: To study the birth weight pattern in chronic as well as currently undernourished pregnant women. Design: Prospective study of rural pregnant women by following eligible women. Setting: Two adjoining blocks of rural Varanasi. Methods: 3700 pregnant women from rural areas of Varanasi for whom data for anthropometry, hemoglobin, dietary intake, birth weight, fundal height and abdominal girth at 16±2, 28±2 and 36±2 weeks of gestation were recorded. Outcome measure was birth weight pattern of newborns. Results: Of the births, 7.2% were <2250 g and 27.4% <2500 g. The weekly birth weight increments in gestation 36-42 weeks were 5-53 g, only. The fundal height did not increase during 35-39 weeks of gestation (lower by 5 cm as compared to normal). Nutrition supplement in the third trimester significantly increased fundal height and abdominal girth. Fundal height below 24.5 cm at 28 weeks of gestation (1368 women) was associated with higher low birth weight deliveries. Conclusions: Birth weight and fundal height increments during later pregnancy are low in undernourished pregnant women. Fundal height <24.5 cm at 28 weeks of gestation identified women with higher risk for lowbirth weight infants. The prevalence of low birth weight was 27.4% and of prematurity was 6.6%.
Brain free amino acids glutamic acid system in growing rats fed wheat & Bengalgram protein diets
(1979) C. Prasad; S. Mehta; K.N. Agarwal
[No abstract available]
Brain MRI and cognitive evoked potentials in rural chronically undernourished children
(Elsevier Inc., 1996) U.K. Misra; J. Kalital; Sunil Kumar; H. Poptani; D.K. Agarwal; K.N. Agarwal
Magnetic resonance imaging (MRI) and cognitive evoked potentials were studied in 21 (10-13 year of age) rural undernourished children (2 were female). 17 healthy age and sex matched volunteers. Their neurological examination was normal and all were right handed. Three undernourished and 2 control children had hyperintense signals on T2 in MRI. The anterior and posterior hemispheric asymmetry was less pronounced in undernourished children (P < 0.01). P3 latency although was normal but the amplitudes of P2 and P3 were higher in the study group in all derivations (P < 0.01). This is consistent with a compensatory phenomenon following earlier nutritional deprivation.
Cholesterol and free fatty acids in the placenta, maternal and cord sera of under-nourished mothers
(1978) G.P. Katiyar; R. Dhawan; K.N. Agarwal; D. Sharma
[No abstract available]
Chronic gastric volvulus--an unusual complication of poliomyelitis.
(1995) A. Kumar; D. Chaudhary; K.N. Agarwal; V. Bhargava
[No abstract available]
Clinical and aetiological study of childhood mental retardation
(1974) G. Subrahmanyam; K.N. Agarwal; S.P. Agarwal; A. Jaiswal
[No abstract available]
Congenital haemorrhagic disorders in paediatric practice
(Springer India, 1974) S.M. Dubey; B. Dube; K.N. Agarwal
Clinical and diagnostic laboratory findings are described in all cases of haemophilia A and 2 cases of haemophilia B. Bleeding from the umbilical stump, an unusual feature, was noted in 2 cases of haemophilia A and one case of haemophilia B. In all the patients with haemophilia A, haemostasis was achieved by the transfusion of a single unit of fresh blood or plasma. The control of bleeding in haemophilia B was difficult and required many transfusions. © 1974 Dr. K C Chaudhuri Foundation.
Cord serum and placental tissue iron status in maternal hypoferremia
(1979) P.N. Singla; S. Chand; K.N. Agarwal
Studies on 85 mothers term infants and 32 mothers with preterm infants revealed that the cord serum and placental tissue iron levels were significantly reduced (P<0.001) in the mothers with hypoferremia (serum iron ≤ 50 μg/100 ml). These levels were found to have linear correlations with the maternal serum iron levels, suggesting that the fetus and the placenta extracted iron in amounts proportional to the levels available in the mother. The high serum iron values in cord blood compared to the maternal blood even in the mothers with hypoferremia suggested that the process of active transfer of iron from mother to the fetus was maintained in maternal iron deficiency.
Developmental assessment of intrauterine growth retarded babies of varying maternal etiology
(Springer India, 1990) B.D. Bhatia; K.N. Agarwal; N.P. Jain
Head circumference was measured serially and developmental performance assessed at the age of 9 months in 41 full-term intrauterine growth retarded babies of varying maternal etiologies. 18 full term and 12 preterm babies who were appropriate for gestational age (AGA) served as controls. The IUGR babies of undernourished mothers had maximum retardation in head circumference.The IUGR babies of small sized mothers had head circumference equal to that of fullterm AGA babies. The IUGR babies of mothers with toxemia of pregnancy and idiopathic group also reached very close to that of fullterm AGA babies for head circumference demonstrating catch up growth. 19.5 per cent of IUGR (as homogenous group) babies were found to have delayed development compared to 16.7 per cent of preterm and 5.6 per cent of fullterm AGA babies. Amongst IUGR groups, babies of undernourished mothers were found to suffer most, followed by babies of mothers with toxemia of pregnancy. None of the babies in the idiopathic group and only one out of 12 in small maternal size group were found to have delayed development. © 1990 Department of Pediatrics All India Institute Of Medical Science.
Developmental lag in preschool children of goitrous mothers
(1983) S.K. Upadhyay; K.N. Agarwal; A. Rani; S. Cherian; A.M. Tripathi; D.K. Agarwal
[No abstract available]
Dietary intakes of urban and rural pregnant, lactating and non-pregnant, non-lactating vegetarian women of Varanasi
(1981) B.D. Bhatia; D. Banerjee; D.K. Agarwal; K.N. Agarwal
A total of 184 pregnant, 95 lactating and 20 non-pregnant, non-lactating (NPNL) vegetarian women from the urban and rural areas of Varanasi were subjected to analysis of their dietary intakes. The diets of both pregnant and lactating women were inadequate in calories, calcium, retinol and riboflavin, as compared to the Indian Council of Medical Research recommendations. The pregnant women had also lower intakes of iron and riboflavin. The intakes of urban pregnant women were lower and those of rural pregnant women higher, as compared to their NPNL counterparts. The mean intakes of various nutrients in urban and rural lactating women were higher as compared to the pregnant and NPNL counterparts. The intakes of urban lactating women were higher as compared to rural lactating women. There was inadequate food intake rather than a protein gap.
Effect of dietary protein composition on hepatic protein and enzymes (arginase tyrosine amino transferase and lactic dehydrogenase) in young rats
(1984) R.D. Gupta; K.N. Agarwal; O.P. Malhotra
[No abstract available]
Effect of dietary protein composition on placental protein, nucleic acid, free α amino N and enzymes in rats
(1980) R.D. Gupta; K.N. Agarwal
Pregnant rats were fed 6 different diets from the first to the 15th, 17th or 19th day of pregnancy. Diets 1 to 5 contained the same amount of nitrogen (10% casein and unsupplemented or supplemented wheat or Bengalgram diets). Diet 6 contained 20% casein. Total placental protein, RNA, free α amino N contents and the activities of the enzymes arginase (EC 3.5.3.1), tyrosine amino transferase (TAT, EC 2.6.1.5) and lactate dehydrogenase (LDH, EC 1.1.1.27) were estimated. The fetal weight and placental weight, total placental protein, RNA and free α amino N and the activities of the enzymes increased with the gestational age, but the DNA content became constant after day 17 of gestation. The placental weight, protein, free α amino N and RNA contents were significantly reduced on wheat and Bengalgram diets as compared to 10% casein (control) diet. The low activities of arginase, TAT and LDH on these diets indicated impaired protein synthesis, as a result of reduction in the amino acid pool size. The fortification of wheat with lysine and Benglagram with cystine, methionine and tryptophan showed significant improvement in the fetal weight and placental parameters. The values on the 20% casein diet were significantly higher than those observed on the 10% casein diet.
Effect of Early Iron Deficiency in Rat on the γ‐Aminobutyric Acid Shunt in Brain
(1986) Veena Taneja; Kamalapati Mishra; K.N. Agarwal
Early iron deficiency in rat does not affect the weight or the protein, DNA, and RNA content but results in a slight reduction in γ‐aminobutyric acid (GABA) (13%, p < 0.01) and glutamic acid (20%, p < 0.001) content of the brain. The activities of the two GABA shunt enzymes, glutamate dehydrogenase and GABA‐transaminase, and of the NAD+‐linked isocitrate dehydrogenase (ICDH) were inhibited whereas the glutamic acid decarboxylase, mitochondrial NADP+‐linked ICDH, and succinic dehydrogenase activities remained unaltered in brain. On rehabilitation with the iron‐supplemented diet for 1 week, these decreased enzyme activities in brain attained the corresponding control values. However, the hepatic nonheme iron content increased to about 80% of the control, after rehabilitation for 2 weeks. A prolonged iron deficiency resulting in decreased levels of glutamate and GABA may lead to endocrinological, neurological, and behavioral alterations. Copyright © 1986, Wiley Blackwell. All rights reserved
Effect of irradiation and vinblastine administration on free α amino nitrogen changes in plasma, erythrocyte and leucocyte
(1975) H. Lal; K.N. Agarwal
The free α amino nitrogen concentrations in plasma and erythrocytes were significantly lowered, whereas leucocytes showed a marked increase after localized irradiation or vinblastine administration. Irradiation also induced a fall in total plasma proteins and albumin concentrations, whereas the administration of vinblastine was associated with highly significant polymorphonuclear neutropenia.