Browsing by Author "N.P. Gupta"

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Controlled clinical trial of allylestrenol im the medical management of benign prostatic hyperplasia
(1997) N.P. Gupta; Monish Aron; K.M. Singh; R.B. Dwivedi
Drug therapy is a major treatment option in the medical management of benign prostatic hyperplasia (BPH). We designed a placebo controlled clinical trial, to study the efficacy and safety of Allylestrenol. From 3 centers, there were 90 cases and 90 controls. The following parameters were evaluated at 0, 3 and 6 months: symptom score (SS), prostate size (PS), maximum flow rate (MFR), post-void residual urine (PVR) and serum testosterone levels (T). The cases were started on tab.Allylestrenol 25 mg. and the controls on tab. B-complex twice a day. At 3 and 6 months, in the Allylestrenol group there was significant improvement in respect of symptom score, prostate size and maximum flow rate. There was no significant difference in the post-void residual urine. There was a significant decline in serum testosterone levels in the Allylestrenol group when compared to controls. The results are shown in the following table: SS PS MFR PVR T BASELINE CASES 13.50 32.47 11.85 74.12 20.80 CONTROLS 12.75 34.14 13.15 66.31 21.60 3 MONTHS CASES 9.04 28.75 14.12 60.65 CONTROLS 12.36 36.25 11.71 51.02 6 MONTHS CASES 6.89 25.01 15.08 49.14 17.15 CONTROLS 13.17 36.76 11.25 58.78 21.59 In the Allylestrenol group, transient nausea and vomiting was seen in 3 cases and 11 cases had a loss of libido that reversed on stopping the drug. We conclude that Allylestrenol is an effective drug for medical management of BPH.
Effect of zero‐point energy on the specific heats of solidified neon and xenon
(1966) N.P. Gupta; B. Dayal
The specific heats of neon and xenon are calculated from a study of their lattice vibrations. The effect of zero‐point energy is included by an iterative method and a Buckingham exponential potential is used. The calculated and experimental values of Cv agree well for xenon but not so well for neon. It is suggested that the interatomic forces in neon are similar to those in helium and that a Buckingham potential, which is applicable to solids formed from heavy rare gases, is inapplicable to solid neon. Copyright © 1966 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Equation of State of Solid Argon and Krypton
(1967) N.P. Gupta; B. Dayal
The equation of state, thermal expansion, and isothermal compressibilities of solidified argon and krypton are studied in the harmonic approximation. An exponential interatomic potential is used, and zero‐point quantum effects are included. There is good agreement between the calculated and the observed values. Copyright © 1967 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Theoretical Phonon Spectra and Heat Capacities of Solidified Argon and Krypton
(1966) N.P. Gupta; B. Dayal
The phonon spectra of solidified Argon and Krypton have been calculated on the basis of the Born‐Karman theory using the interatomic potential ϕ(r) = ‐Ar−6 + AB × exp (‐r/Q), and taking into account the zero‐point energy and interactions of the four nearest neighbours. The evaluation of the parameters A, B, and Q requires a knowledge of the vibration spectrum of the crystal which is itself a function of these constants. A method of iteration is therefore employed to evaluate the potential parameters, after estimating the frequency‐dependent terms using the Debye theory of specific heats. The static lattice energy is obtained by a method of successive approximations. The specific heats and (θ,T) curves show a fair agreement with the experimental results. Copyright © 1966 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Theoretical phonon spectra and heat capacities of solidified argon and krypton
(De Gruyter, 2021) N.P. Gupta; B. Dayal
The phonon spectra of solidified Argon and Krypton have been calculated on the basis of the Born-Karman theory using the interatomic potential ç>(r) = - Ar~* 4- AB x X exp (-r/ρ), and taking into account the zero-point energy and interactions of the four nearest neighbours. The evaluation of the parameters A, B, and ρ requires a knowledge of the vibration spectrum of the crystal which is itself a function of these constants. A method of iteration is therefore employed to evaluate the potential parameters, after estimating the frequency-dependent terms using the Debye theory of specific heats. The static lattice energy is obtained by a method of successive approximations. The specific heats and (ØD, T) curves show a fair agreement with the experimental results. © 2021 De Gruyter. All rights reserved.
Thermal Expansion and Compressibility of Solid Neon and Xenon
(1967) N.P. Gupta; B. Dayal
The lattice constants and isothermal compressibility of solidified neon and xenon are calculated at various temperatures for the harmonic approximation. An (exp, 6) potential function is used and zero‐point energy is included in the same way as in earlier papers. The theoretical and observed values of lattice constants and compressibility agree reasonably well for xenon but not so well for neon. It is suggested that the interaction in neon is somewhat analogous to that in helium, and the usual potentials which are applicable to heavy rare gas solids i.e. argon, krypton and xenon, are not suitable for neon. Copyright © 1967 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim