Browsing by Author "Neha Sharma Prabhakar"

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A regioselective synthesis of β-difluoromethoxy vinyl sulfones via O-difluoromethylation of β-ketosulfones using sodium chlorodifluoroacetate
(Royal Society of Chemistry, 2023) Km Ishu; Neha Sharma Prabhakar; Krishna Nand Singh
A practical synthesis of new β-difluoromethoxy vinyl sulfones has been explored by O-difluoromethylation of β-ketosulfones using the inexpensive and easily workable sodium chlorodifluoroacetate as a difluorocarbene precursor. The strategy is convenient and regioselective, and features an adequate substrate scope and functional group tolerance. © 2023 The Royal Society of Chemistry.
Decarboxylative Alkenylation of Imidazo[1,2-a]pyridines using α,β-Unsaturated Carboxylic Acids via Pd-Catalysed C-H Functionalization
(Georg Thieme Verlag, 2023) Saurabh Kumar; Neha Sharma Prabhakar; Kaushal Kishor; Krishna Nand Singh
An efficient synthesis of alkenylated imidazo[1,2-a]pyridines has been accomplished using imidazo[1,2-a]pyridines and α,β-unsaturated carboxylic acids adopting C-H functionalization strategy in the presence of palladium acetate, 1,10-phenanthroline, and silver carbonate. © 2023 Georg Thieme Verlag. All rights reserved.
Easy Access to α-Ketothioamides via Oxidative Amidation of Bunte Salts Using Electrolysis or Hypervalent Iodine
(American Chemical Society, 2024) Neha Sharma Prabhakar; Kaushal Kishor; Krishna Nand Singh
Two new protocols leveraging electrochemical and hypervalent iodine-mediated synthesis of α-ketothioamides have been developed by using easily accessible and cost-effective Bunte salts and secondary amines. The methods are efficient, simple, and straightforward, and showcase the formation of C-N bonds across diverse substrates under ambient conditions. © 2024 American Chemical Society.
Iodine-mediated regioselective C-3 sulfenylation using elemental sulfur and arylhydrazine hydrochloride to access 3-sulfenylated imidazo[1,2-a]pyridines
(Royal Society of Chemistry, 2025) Kaushal Kishor; Neha Sharma Prabhakar; Krishna Nand Singh
A transition metal-free protocol for the regioselective C-3 sulfenylation of imidazo[1,2-a]pyridines has been explored using arylhydrazine hydrochloride and elemental sulfur, in the presence of molecular iodine and DABCO via C(sp2)-H functionalization to achieve structurally diverse 3-sulfenylated imidazo[1,2-a]pyridines in reasonably high yields. © 2025 The Royal Society of Chemistry.
Iodine/DMF-Mediated Regioselective Sulfenylation Using Arenediazonium Tosylates and Sodium Metabisulfite: An Easy Access to 3-Arylthioindoles
(American Chemical Society, 2024) Aditya Rai; Neha Sharma Prabhakar; Kaushal Kishor; Krishna Nand Singh
A practical C3 sulfenylation of indoles has been accomplished using arenediazonium tosylates and sodium metabisulfite, with a key role of iodine/DMF combination in the reaction. The method involves scarce use of sodium metabisulfite as a divalent sulfur source and offers an array of structurally diverse 3-arylthioindoles in high yields under operationally simple transition-metal-free and mild conditions. © 2024 American Chemical Society.
Visible-Light-Induced Photocatalytic Trifluoromethylation of Bunte Salts: Easy Access to Trifluoromethylthiolated Synthons
(American Chemical Society, 2022) Neha Sharma Prabhakar; Saurabh Kumar; Prince Kumar Gupta; Krishna Nand Singh
A metal-free visible-light-induced trifluoromethylation of Bunte salts of α-bromoketones/alkyl bromide/benzyl bromides/functionalized allyl (Baylis-Hillman) bromides has been accomplished using Langlois' reagent in the presence of inexpensive eosin Y as a photocatalyst to form the privileged trifluoromethylthiolated synthons. The method is straightforward, operationally simple, and endowed with broad substrate scope and good functional group tolerance. © 2022 American Chemical Society. All rights reserved.
Visible-Light-Mediated Synthesis of α-Ketoamides via Oxidative Amination of 2-Bromoacetophenones Using Eosin Y as a Photoredox Catalyst
(John Wiley and Sons Ltd, 2023) Kaushal Kishor; Neha Sharma Prabhakar; Krishna Nand Singh
An oxidative amination of 2-bromoacetophenones has been accomplished to provide α-ketoamides by using photoredox catalysis with air as oxidant. The reactants are readily accessible, and the method is endowed with broad substrate scope and good functional group tolerance. The practicality of the approach is also shown by a gram-scale reaction. © 2023 Wiley-VCH GmbH.