Browsing by Author "Nikhil Pandey"

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A comprehensive and critical narrative review on movement disorders linked through dengue virus based infection
(Springer-Verlag Italia s.r.l., 2025) Niraj Kumar Srivastava; Nikhil Pandey; Janki Makani; Ibrahim Hussain; Neetu Rani Dhiman; Anand Kumar; Deepika Srivastava Joshi
Background: Dengue virus (DENV) has emerged as a significant cause of neurological complications, including movement disorders, which fall under the broader category of neurological manifestations associated with DENV infection. These disorders can have serious implications for patient’s quality of life, especially in tropical and subtropical regions where dengue is endemic. The neurological complications of DENV, while less commonly recognized when compared to its classical features (like fever, haemorrhagic manifestations, or shock), are increasingly being reported thus warranting an exhaustive exploration. Methods: We undertook a comprehensive and critical review to investigate the emerging link between movement disorders and DENV infections. An in depth and broad range search was performed across leading scientific databases (PubMed, Scopus, Embase and Google Scholar). We collected and analyzed a wide spectrum of relevant studies and case reports. This detailed methodology ensured a systematic and authoritative exploration of the neurological consequences associated with DENV, creating the foundation for deeper clinical insight and future research. Results: The analysis encompassed 80 studies on movement disorders linked to DENV infections. These studies were thoroughly reviewed and critically evaluated, with the findings presented in an inclusive and investigative manner. Conclusion: This narrative review provides a comprehensive analysis of movement disorders linked to DENV infections, enveloping their epidemiology, clinical features, neuropathogenesis, current therapeutic strategies, and outlining extensive directions for future research. © Fondazione Società Italiana di Neurologia 2025.
A comprehensive expedition of tauopathies in subacute sclerosing panencephalitis (SSPE): a narrative review
(Springer Science and Business Media Deutschland GmbH, 2024) Nikhil Pandey; Niraj Kumar Srivastava; Anand Kumar; Ibrahim Hussain; Deepika Joshi
Introduction: Tauopathies are a class of neurodegenerative disorders characterized by the abnormal accumulation of hyperphosphorylated tau protein in the brain. Subacute sclerosing panencephalitis (SSPE) caused by a latent aberrant measles virus infection, is characterized by extensive inflammation and neuronal impairment. A prominent pathological hallmark of SSPE described recently is the accumulation of abnormal tau protein possibly resulting from diffuse brain inflammation triggered by measles virus infection. Short summary: Understanding the role of tau pathophysiology in SSPE is crucial for improving the diagnosis and management of this debilitating condition. Current research suggests that persistent measles virus infection in the brain leads to chronic inflammation, which in turn triggers abnormal tau phosphorylation and accumulation. Further elucidating the precise mechanisms linking measles virus infection, neuro-inflammation, and tauopathy in SSPE is essential for developing targeted therapies. Conclusion: This narrative review provides valuable insights for both researchers and clinicians in understanding the pathological mechanisms underlying SSPE which is crucial for developing effective treatment strategies. These might include antiviral drugs to combat persistent infection, anti-inflammatory agents to reduce neuro-inflammation, or even treatments targeting tau pathology directly. Collaborative efforts among researchers, clinicians, and public health authorities are crucial for advancing our understanding of SSPE to combat this devastating disorder. © The Author(s) 2024.
Antidiabetic role of Swertia chirayita: Phytochemical and pharmacological perspective of a Himalayan botanical
(Bentham Science Publishers, 2023) Nikhil Pandey; Priyanka Mishra; Yamini B Tripathi
As the Himalayan mountains and valleys keep on the continuous progression of their expansion during evolution, so does their cradle of medicinal plants. Humans started to find answers to various ailments by studying these medicinal plants. One such valuable medicinal plant from the Himalayas is called Swertia chirayita (Chiraito, SC), which shows a variety of therapeutic properties. SC has been shown to be effective in a wide therapeutic spectrum and acts as an anti-oxidant, anti-inflammatory, hypoglycaemic, anti-diabetic, anti-obesity, anti-tumor, anti-microbial, and chemoprotective agent. Due to its numerous medicinal properties, it is one of the main ingredients in a variety of herbal preparations in Ayurveda, Unani, Siddha, Tibetian, and Traditional Chinese medicines. Apart from the traditional medicine systems, it is systematically mentioned under various pharmaceutical codexes like the Indian, UK, and American pharmacopeias. SC is significantly used as an anti-diabetic in various herb-based medicinal practices. Swertia chirayita is one of the very important plants known for its hypoglycaemic potential and hence exhibits a potential for the management of type II diabetes. © 2023 Bentham Science Publishers. All rights reserved.
Cumulative influence of immunogenic factors, genetic variations, and protein modulations in subacute sclerosing panencephalitis (SSPE): A narrative review
(John Wiley and Sons Inc, 2025) Nikhil Pandey; Niraj Kumar Srivastava; Anand Kumar; Ibrahim Hussain; Deepika Srivastava Joshi
Subacute sclerosing panencephalitis (SSPE) is a progressive and catastrophic neurodegenerative disorder due to persistent infection with the aberrant measles virus in the brain. The exact etiology of SSPE is still unknown, and early diagnosis remains a challenge, especially with the atypical presentations. The pathogenesis of SSPE involves a complex interplay between viral factors and immunological response of the host. The presenting review demonstrates an extensive glimpse of the immuno-genetics of SSPE, exploring the single-nucleotide polymorphisms (SNPs), genetic risk factors and immune responses that influence susceptibility and disease progression. © 2024 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd.
Cumulative influence of immunogenic factors, genetic variations, and protein modulations in subacute sclerosing panencephalitis (SSPE): A narrative review
(John Wiley and Sons Inc, 2024) Nikhil Pandey; Niraj Kumar Srivastava; Anand Kumar; Ibrahim Hussain; Deepika Joshi
Subacute sclerosing panencephalitis (SSPE) is a progressive and catastrophic neurodegenerative disorder due to persistent infection with the aberrant measles virus in the brain. The exact etiology of SSPE is still unknown, and early diagnosis remains a challenge, especially with the atypical presentations. The pathogenesis of SSPE involves a complex interplay between viral factors and immunological response of the host. The presenting review demonstrates an extensive glimpse of the immuno-genetics of SSPE, exploring the single-nucleotide polymorphisms (SNPs), genetic risk factors and immune responses that influence susceptibility and disease progression. © 2024 Japanese Society of Neurology and John Wiley & Sons Australia, Ltd.
Medicinal plants from the himalayas acting on inflammatory and oxidative stress pathways
(Bentham Science Publishers, 2023) Priyanka Mishra; Nikhil Pandey; Yamini B Tripathi
Located between the Indian subcontinent and the Tibetan plateau, the Himalayas are home to a rich repertoire of medicinal resources. A wide range of communities from Asia and Africa prefer natural remedies, including medicinal plants, over prescription drugs. Since so many people use medicinal plants as their only source of healing, the plants are also an important source of income for the locals.. The plants found in the entire region of this snowy mountain range provide remedies ranging from bronchitis to cancer. We attempted to summarise the important medicinal plants of this region in this book chapter, specifically those that act and modulate the inflammatory and oxidative stress pathways, as these are the primary culprits behind many diseases and disorders. The current chapter will list the ethnobotanicals used, their active ingredients, and reported pharmacological properties, as well as potential mechanisms of action. © 2023 Bentham Science Publishers. All rights reserved.
Prevention of mortality in acute lung injury induced by oleic acid: Application of polyherbal decoction (bronco T)
(Frontiers Media S.A., 2022) Priyanka Mishra; Ratna Pandey; Nikhil Pandey; Suyash Tripathi; Yamini Bhusan Tripathi
Acute lung injury (ALI) is a lethal respiratory disorder; directed uncontrolled inflammation, sloughing of the alveolar cells and their diffusion, and altered cardiorespiratory parameters with a global mortality rate of 40%. This study was designed to assess the preventive effect of a polyherbal decoction (Bronco T, 1.5 g/kg b. w.) on cardiorespiratory variables in oleic acid-induced ALI in rats. Oleic acid increases the level of neutrophil infiltration leading to pulmonary edema and alters the cardiorespiratory dynamics. The adult male rats were surgically cannulated and treated with intravenous oleic acid (0.38 ml/kg b. w.) to establish the ALI model. Bronco T was pre-administered orally 3 hours before oleic acid. The biophysical, histological, biochemical, and molecular effects were compared with dexamethasone (5 mg/kg b. w. i. p.). The animals were randomly divided into control, lethal, standard, and treatment groups. Respiratory frequency (RF), heart rate (HR), and mean arterial pressure (MAP) were recorded on a computerized chart recorder; arterial blood sample was collected to determine PaO2/FiO2, TNF-α, and MPO. Lipid peroxidation, superoxide dismutase, and catalase activity were evaluated to measure oxidative stress in bronchoalveolar lavage. Additionally, the pulmonary water content, COX-2 expression and histological examination were determined in the lung. A molecular docking study of the active phytoconstituent of BT obtained from HR-LCMS analysis against reported targets (IL-6, COX-2, TNFα, MPO and ENaC) of ALI was carried out. The B.T. pretreatment prevents mortality in comparison to the oleic acid group. It protects the lungs and heart from the detrimental effect of oleic acid, on par with dexamethasone. COX-2 mRNA expression was significantly down-regulated in the treatment group. The reduced level of TNF-α, MPO, SOD and catalase supported the protective effect of B.T. The in silico study revealed strong binding interaction between the phytoconstituent (Galangin 3- [galactosyl-(1–4)-rhamnoside and Beta solamarine] of BT and the reported target. The B.T. pre-administration attenuates the oleic acid-induced mortality and cardiorespiratory toxicity. Copyright © 2022 Mishra, Pandey, Pandey, Tripathi and Tripathi.
Role of Ayurvedic Plants as Anticancer Agents
(Humana Press Inc., 2022) Nikhil Pandey; Y.B. Tripathi
The use of natural products has been increasing at a rapid pace, worldwide, with the aim to maintain a healthy lifestyle and to modify one’s dietary habits. Ayurveda is a domain that has numerous wealth of information concerning medicinal plants and its part in controlling numerous ailments, such as neoplastic, cardiovascular, neurological plus immunological ailments. The use of such medicinal plants is important for preventing such diseases, especially “cancer” which is the succeeding foremost cause of mortality collectively. Even though abundant developments have been made in the management and control of cancer progression, substantial deficits and scope for advancement still continue to be unchanged. Several lethal adjacent consequences occur throughout the course of chemotherapy. Natural treatments, such as the use of plant-derived products in the treatment of cancer, might reduce the hostile side effects. Presently, a few plant-based products and its phytoconstituents are being utilized for the management of cancer. Here we have focused on numerous plant-derived phytochemicals and promising compounds from these plants to act as anticancer agents, along with their mechanisms of action. © 2022, The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.
Urinary based biomarkers identification and genetic profiling in Parkinson’s disease: a systematic review of metabolomic studies
(Frontiers Media SA, 2025) Neetu Rani Dhiman; Surbhi Singh; Royana Singh; Anand Kumar; Varun Kumar Singh; Abhishek Pathak; Rameshwar Nath Chaurasia; Vijay Nath Mishra; Niraj Kumar Srivastava; Swati Sahu; Nikhil Pandey; Deepika Srivastava Joshi
Background: Parkinson’s disease is a complex, age-related, neurodegenerative disease associated with dopamine deficiency and both motor and nonmotor deficits. Therapeutic pathways remain challenging in Parkinson’s disease due to the low accuracy of early diagnosis, the difficulty in monitoring disease progression, and the limited availability of treatment options. Objectives: Few data are present to identify urinary biomarkers for various ailments, potentially aiding in the diagnosis and tracking of illness progression in individuals with Parkinson’s disease. Thus, the analysis of urinary metabolomic biomarkers (UMB) for early and mid-stage idiopathic Parkinson’s disease (IPD) is the main goal of this systematic review. Methods: For this study, six electronic databases were searched for articles published up to 23 February 2024: PubMed, Ovid Medline, Embase, Scopus, Science Direct, and Cochrane. 5,377 articles were found and 40 articles were screened as per the eligibility criteria. Out of these, 7 controlled studies were selected for this review. Genetic profiling for gene function and biomarker interactions between urinary biomarkers was conducted using the STRING and Cytoscape database. Results: A total of 40 metabolites were identified to be related to the early and mid-stage of the disease pathology out of which three metabolites, acetyl phenylalanine (a subtype of phenylalanine), tyrosine and kynurenine were common and most significant in three studies. These metabolites cause impaired dopamine synthesis along with mitochondrial disturbances and brain energy metabolic disturbances which are considered responsible for neurodegenerative disorders. Furoglycine, Cortisol, Hydroxyphenylacetic acid, Glycine, Tiglyglycine, Aminobutyric acid, Hydroxyprogesterone, Phenylacetylglutamine, and Dihydrocortisol were also found commonly dysregulated in two of the total 7 studies. 158 genes were found which are responsible for the occurrence of PD and metabolic regulation of the corresponding biomarkers from our study. Conclusion: The current review identified acetyl phenylalanine (a subtype of phenylalanine), tyrosine and kynurenine as potential urinary metabolomic biomarkers for diagnosing PD and identifying disease progression. © © 2025 Dhiman, Singh, Singh, Kumar, Singh, Pathak, Chaurasia, Mishra, Srivastava, Sahu, Pandey and Joshi.