Browsing by Author "P.K. Debnath"

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A comparative study on the gastric secretory response of histamine and pentagastrin on the same Indian subjects
(1980) J.P. Gupta; Y. Rai; P.K. Debnath; A.K. Sanyal
[No abstract available]
A study of gastric aspirate in normal and preterm infants on first day of life
(1974) P.K. Debnath; N. Ahmed; V. Bhargava; A.K. Sanyal
A study was conducted on the gastric aspirate of 85 normal term and 53 preterm babies to find out their patterns of gastric acidity and peptic activity. The pH in normal term babies was 5.6 at birth and the value dropped to 2.2 by 2-8 hr. In contrast, in preterm, the pH value remained more than 4 even after 24 hr. Similarly, no titrable free acid was detectable in the preterm babies up to 24 hr of life. The peptic activity was detectable in full term newborns by 2-4 hr, while in the preterm babies this activity did not appear even up to 24 hr after birth.
Antagonism of some central pharmacological actions of prostaglandin E1 by prostaglandin F(2α) in rat
(1978) S.K. Bhattacharya; P.K. Debnath; A.K. Sanyal
Prostaglandin F2α (PGF2α) was found to significantly inhibit protaglandin E1 (PGE1) induced potentiation of morphine antinociception, anticonvulsant action of phenobarbitone and hexobarbitone hypnosis, as well as PGE1 induced inhibition of pentylenetetrazol convulsions in rat. Earlier studies suggested that all these pharmacological actions of PGE1 were serotonin-mediated. It appears that PGF2α-induced inhibition of PGE1 actions is brought about by modulating central serotonergic neurotransmission in the rat.
Antiulcerogenic activity of Satavari mandur-An ayurvedic herbo-mineral preparation
(2002) G.K. Datta; K. Sairam; S. Priyambada; P.K. Debnath; R.K. Goel
Satavari mandur (SM) is a herbo-mineral preparation containing Asparagus racemosus, which finds mention in ancient Indian texts for treatment of gastric ulcers. The ulcer protective effect of SM, 125-500 mg/kg given orally, twice daily for three, five and seven days, was studied on cold restraint stress-induced gastric ulcer in rats. The effective regimen was found to be 250 mg/kg given for five days and hence was used for further experiments. SM showed significant protection against acute gastric ulcers induced by pyloric ligation but was ineffective against aspirin- and ethanol-induced ulcers. Further, gastric juice studies showed that, SM significantly increased the mucosal defensive factors like mucus secretion, but had little of no effect on offensive factors like acid and pepsin secretion.
Effect of 5 hydroxytryptamine antagonist on gastric secretion in albino rats
(1975) P.K. Debnath; R.K. Goel; A.K. Sanyal
[No abstract available]
Effect of prostaglandins on gastrointestinal smooth muscle
(1977) S.B. Acharya; P.K. Debnath; C. Dey; A.K. Sanyal
[No abstract available]
Effect of some β-adrenoceptor blockers on gastric secretion and ulceration in shay rats
(1977) R.K. Goel; P.K. Debnath; C. Dey; A.K. Sanyal
A comparative study of the effect of β-adrenoceptor antagonists on basal gastric secretion was undertaken in pylorus ligated Wistar albino rats. All the three antagonists i.e. propranolol, LB46 and practolol showed a dose-dependent effect on gastric secretion and ulceration. Small doses increased the volume, total acid and chloride output and pepsin secretion along with an increase in the ulcer index. High doses of all the three drugs caused inhibition of acid, chloride, pepsin output and ulcer index.
Five minutes' field study on each Indian hockey player in a coaching camp.
(1990) A.K. De; P.K. Debnath
Peak expiratory flow rate (PEFR) was measured using portable Wright's peak flow meter on 21 male hockey players of Indian national hockey team probables attending a zonal coaching camp. The mean PEFR was observed to be 580.95 +/- 43.34 1/minute. The PEFR in hockey players were higher than those recorded in inter-university 'kabaddi', basketball players and football goalkeepers. All the group of players had shown higher mean PEFR than those of age matched healthy Indian males.
Gastric inhibitory effect of prostaglandins
(1974) A.K. Sanyal; P.K. Debnath
[No abstract available]
Gastric secretory pattern in pre-term neonates
(1977) N. Ahmed; P.K. Debnath; V. Bhargava; K.N. Agarwal; A.K. Sanyal
The gastric secretory pattern on the first day of life was studied in 21 full-term, 6 small-for-date and 25 pre-term babies. Free acid and peptic activity though absent or low at birth in full-term babies apeared rapidly and were present in 95 per cent of the babies within 8 hours. In contrast, free acid and peptic activity could be detected in only 40 and 14 per cent respectively of the pre-term babies even 3 hours after the first feed. Small-for-date babies resembled the full-term group. In a follow-up of 8 pre-terms (gestational ages between 29-32 weeks) peptic activity though absent in all except one (born at 29 weeks) at birth, appeared 2-5 weeks after birth. Further, in another 8 pre-term babies born at 34 weeks of gestation, peptic activity was detectable within 1-2 days after birth in seven babies and after one week in one baby. Thus it is suggested that peptic activity probably appears in the gastric juice between 34-35 weeks of foetal life.
Gastric secretory pattern in thermal burns
(1977) D.K. Gupta; S.K. Roy; P.K. Debnath; C. Dey; A.K. Sanyal
[No abstract available]
Intestinal ulcerogemic activity of some non steroidal antiinflammatory agents
(1981) S.B. Acharya; Y.V. Rao; P.K. Debnath; A.K. Sanyal
Several antiinflammatory agents were studied for their intestinal ulcerogenic effects in rats employing the method of Ezer and Szporny (1975). Each drug was administered orally for 3 days. The intestinal tensile strength was significantly decreased by indomethacin (IND, 10 mg/kg), diclofenac sodium (DS, 15 mg/kg) and sodium salicylate (SS, 10 mg/kg). IND induced decreased intestinal tensile strength was reversed by SS (100 mg/kg), aspirin (ASP, 300 mg/kg), hydrocortisone (HC, 20 mg/kg) and 15(S), 15 methyl PGF2α (MPGF, 400 μg/kg). SS could only partly protect IND induced decreased intestinal strength in adrenalectomised and metyrapone treated rats. DS response was potentiated by SS, ASP, and paracetamol (PCM, 100 mg/kg). HC did not significantly affect DS induced decreased intestinal tensile strength while MPGF protected it. The data of the present study cannot explain the mechanism of the ulcerogenic effect of IND and DS. © 1981 The Italian Pharmacological Society.
Pharmacological investigations on Elaeocarpus ganitrus
(1975) S.K. Bhattacharya; P.K. Debnath; V.B. Pandey; A.K. Sanyal
[No abstract available]
Potentiation of antinociceptive action of morphine by prostaglandin E1 in albino rats
(1975) S.K. Bhattacharya; P.K.S.P. Reddy; P.K. Debnath; A.K. Sanyal
1. Prostaglandin E1 (0·4 mg/kg, i.p.) significantly potentiated the antinociceptive action of morphine in albino rats. 2. This potentiation was significantly inhibited by pretreatment with reserpine, p‐chlorophenylalanine or methysergide but not by α‐methyl‐p‐yrosine, phentolamine or propranolol. 3. The results suggest that the potentiation of morphine by prostaglandin E1 is mediated by serotonin, since it is inhibited by pharmacological agents known to reduce central turnover of serotonin receptors. Copyright © 1975, Wiley Blackwell. All rights reserved
Presence of proteolytic activity in the amniotic fluid
(1977) A.K. Sanyal; C. Dey; P.K. Debnath; D. Sharma; R. Chatterjee
Proteolytic activity was determined by using hemoglobin as substrate in the amniotic fluid of 105 pregnant women during labour after amniotomy. The gestational age was calculated from the first day of last menstrual period of the mother and also by morphologic and neurologic examination of the newborns. Creatinine concentration and percentage orange cells were also determined. The study showed that proteolytic activity was absent in samples of 28-35 wk of gestation and present in samples of 36-42 wk old pregnancy. The creatinine concentration and orange cell count were less than 2 mg.% and 10% respectively in 28-35 wk of gestation and more than 2 mg.% and 20% respectively in samples of 36-42 wk of gestation. The study suggests that the presence of proteolytic activity could be used as a parameter for determining fetal maturity.
PROSTAGLANDINS: ANTINOCICEPTIVE EFFECT OF PROSTAGLANDIN E1 IN THE RAT
(1977) A.K. Sanyal; S.K. Bhattacharya; P.R. Keshary; D.N. Srivastava; P.K. Debnath
1. The antinociceptive effect of prostaglandins E1, E2 and F2α was studied in albino rats. Though all three prostaglandins produced similar degrees of sedation, only prostaglandin E1 (PGE1) produced a dose‐related antinociceptive activity. 2. The antinociceptive activities of equi‐analgesic doses of morphine (7.5 mg/kg, i.p.) and PGE1 (2.0 mg/kg, i.p.) were inhibited to almost similar extents after pretreatment with drugs known to reduce central turnover of serotonin receptors, namely reserpine, fenclonine (p‐chlorophenylalanine), methysergide and 5,6‐dihydroxytryptamine. 3. Prostaglandin F2α (2.0 mg/kg, i.p.) significantly inhibited the antinociceptive effects of both morphine and PGE1. 4. The prostaglandin synthesis inhibitors, indomethacin and diclofenac, significantly inhibited morphine analgesia. 5. Probenecid markedly prolonged the duration of antinociceptive effect of morphine and the duration of PGE1‐induced potentiation of subanalgesic dose of morphine. 6. The results suggest that, in albino rats, PGE1‐induced antinociceptive activity is serotonin mediated and that morphine analgesia is not only mediated through serotonin but also through prostaglandins (PGE1?) and 5‐hydroxyindole acetic acid, the serotonin metabolite. Copyright © 1977, Wiley Blackwell. All rights reserved
Prostaglandins: effect of prostaglandin E1 on brain, stomach and intestinal serotonin in rat
(1978) P.K. Debnath; S.K. Bhattacharya; A.K. Sanyal; M.K. Poddar; J.J. Ghosh
[No abstract available]
Pulse rate, pre-competition tension and performance in 10,000 meter elite runners of both sexes.
(1990) A.K. De; P.K. Debnath; A.S. Roy; C.R. Murthy
Five male and 3 female runners who participated in 10,000 meter distance run in South Asian Federation (SAF) Games, 1987 were volunteered for this pilot study. The pulse rate at rest, 1 hour prior to competition and post-run for 30 min at 5 min intervals were recorded. It was observed that the runners who showed less rise of pulse prior to competition, performed better. This might be attributed to less pre-competition tension in them which helped the athletes to perform better.
Role of 5-hydroxytryptamine in prostaglandin E1-induced potentiation of hexobarbitone hypnosis in albino rats
(Birkhäuser-Verlag, 1976) S.K. Bhatacharya; S.N. Mukhopadhyay; P.K. Debnath; A.K. Sanyal
PGE1 potentiated, while diclofenac, a prostaglandin synthesis inhibitor, antagonized hexobarbitone hypnosis in rats. PGE1-induced potentiation of hexobarbitone sleep was inhibited by a 5HT synthesis inhibitor and by a 5HT receptor blocker, suggesting that this potentiation is 5HT mediated. © 1976 Birkhäuser Verlag.
Role of mucosubstances in the genesis of stress ulceration produced by electroshock and exhaustive swimming in albino rats
(1980) P.K. Debnath; A.K. De; Chhabi Dey; A.K. Sanyal
[No abstract available]