Browsing by Author "R.C. Gupta"

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A comparative study of urinary oestrogens in the cancer of breast and prostate
(1974) P. Kaul; G.C. Prasad; R.C. Gupta; K.N. Udupa
Estrogens have been estimated in 24 hr urine of breast cancer women during premenopausal and postmenopausal phases, before and after the surgery. There was an increased excretion of one of the fractions of estrogens, i.e. estriol as compared to the normals. There was not much change in the other two fractions, i.e. estrone and estradiol. With the advancement of the disease, there was an increased excretion of the urinary estrogens. Estrogen levels have also been observed in the patients suffering from carcinoma of prostate and a decrease in the urinary estrogen level was observed.
Abrasive wear characteristics of carbon and low alloy steels for better performance of farm implements
(Chinese Soc of Metals, 1995) M. Kumar; R.C. Gupta
The low stress abrasion behaviours of heat treated mild, medium carbon and high C-low Cr steels, which are generally used in making farm implements, have been investigated. The simple heat treatment greatly improves the hardness, tensile strength and abrasion resistance of medium carbon and high C-low Cr steels. The results indicate that the material removal during abrasion is controlled by a number of factors, such as hardness, chemical composition, microstructure and heat treatment conditions. The conclusion is that the heat treated high C-low Cr steel and mild steel carburized by coal-tar pitch provide the best hardness and abrasion resistance and thus appear to be the most suitable materials for making farm tools.
Antagonistic interactions among seedborne microflora and dynamics of microbial incidence
(Springer-Verlag, 1979) R.N. Tandon; R.C. Gupta; A.N. Shukla; D.K. Arora
Seed treatment of Phaseolus mungo Roxb. with non-volatile metabolites of dominant seed fungi such as Chaetomium indicum Corda and Curvularia lunata (Walker) Boedijn and the antibiotic substances: chetomin, curvularin and brefeldin reduced the percent incidence of microfungi and bacteria but induced the Streptomyces sp. The antagonistic behaviour of seed microflora was assessed in vitro. © 1979 Springer-Verlag.
Antitumor and cytotoxic investigation of amoora rohituka
(Informa Healthcare, 1995) T. Rabi; R.C. Gupta
An ethyl acetate extract derived from the stem bark of Amoora rohituka exhibited antitumor activity on mice inoculated with Dalton's lymphoma ascites cells (DLA). Intraperitoneal administration of the extract at doses of 10 or 20 mg/kg/day prolonged the median survival time of the animals. It showed cytotoxicity against Dalton 's lymphoma ascites cells with a 50% inhibitory concentration (IC50) of 9 μg/ml, with no activity against Hep-2 cells from a tumor of the larynx. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Antitumor and cytotoxic investigation of Amoora rohituka
(Swets en Zeitlinger B.V., 1995) T. Rabi; R.C. Gupta
An ethyl acetate extract derived from the stern bark of Amoora rohituka exhibited antitumor activity on mice inoculated with Dalton's lymphoma ascites cells (DLA). Intraperitoneal administration of the extract at doses of 10 or 20 mg/kg/day prolonged the median survival time of the animals. It showed cytotoxicity against Dalton's lymphoma ascites cells with a 50% inhibitory concentration (IC50) of 9 μg/ml, with no activity against Hep-2 cells from a tumor of the larynx.
Biotechnological interventions and genetic diversity assessment in Swertia sp.: a myriad source of valuable secondary metabolites
(Springer Science and Business Media Deutschland GmbH, 2021) Prabhjot Kaur; Devendra Kumar Pandey; R.C. Gupta; Vijay Kumar; Padmanabh Dwivedi; Rupa Sanyal; Abhijit Dey
Abstract: The genus Swertia (Family: Gentianaceae) has cosmopolitan distribution which is present in almost all the continents except South America and Australia. Swertia genus has been renowned as one of the potent herbal drugs in the British, American, and Chinese Pharmacopeias as well as well-documented in the Indian traditional medicinal systems, viz. Ayurveda, Siddha, and Unani. Many species of this genus have therapeutic properties and have been used traditionally in the treatment of a number of health ailments viz. hepatitis, diabetes, inflammation, bacillary dysentery, cancer, malaria, fever etc. This genus is industrially important medicinal plant that has been used as a principal component in numerous marketed herbal/ polyherbal formulations. Medicinal usage of Swertia is endorsed to the miscellaneous compounds viz. xanthones, irridoids, seco-irridoids, and triterpenoids. A chain of systematic isolation of bio-active compounds and their diverse range of pharmacological effects during last 15–20 years proved this genus as industrially important plant. Due to the various practices of the Swertia species, annual demand is more than 100 tons per year for this important herb which is continuously increasing 10% annually. The market value rises 10% by the year as there is increased demand in national and international market resulted in adulteration of many Swertia spp. due to paucity of agricultural practices, exomorphological, phytochemical, and molecular characterization. Thus, efficient biotechnology methods are prerequisite for the mass production of authentic species, sustainable production of bio-active compounds and ex situ conservation. A chain of systematic biotechnological interventions in Swertia herb during last 20 years cover the assessment of genetic diversity, in vitro sustainable production of bio-active compounds and mass propagation of elite genotypes via direct and indirect organogenesis. This review attempts to present the comprehensive assessment on biotechnological process made in Swertia over the past few years. Key points: • Critical and updated assessment on biotechnological aspects of Swertia spp. • In vitro propagation and genetic diversity assessment in Swertia spp. • Biosynthesis and sustainable production of secondary metabolites in Swertia spp. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Corrigendum to “Screening of elite germplasms for industrially valuable medicinal crop Stevia rebaudiana for stevioside and rebaudioside A production: An HPTLC-linked chemotaxonomic assessment” (South African Journal of Botany (2022) 150 (1159–1167), (S0254629922004823), (10.1016/j.sajb.2022.09.004))
(Elsevier B.V., 2023) Shah Nawaz; Prabhjot Kaur; Merinaswari Konjengbam; Vijay Kumar; R.C. Gupta; Padmanabh Dwivedi; Babita Patni; Babita Pandey; Abhijit Dey; Devendra Kumar Pandey
The authors regret that the incorrect Fig. 3 was published in the original article. The correct Fig. 3 is provided herein and this will not affect the results and conclusion of the manuscript. The authors would like to apologise for any inconvenience caused. © 2023 South African Association of Botanists
Effect of fungal staling growth products on colony interaction among Rhizoctonia solani Kuhn and some potential rhizosphere fungi
(Birkhäuser-Verlag, 1979) D.K. Arora; R.C. Gupta; R.N. Tandon
Colony interactions between Rhizoctonia solani Kuhn: a root pathogen of Lycopersicon esculentum Mill and some dominant rhizosphere fungi were assessed in vitro in virgin and staled agar to examine their antagonistic ability and tolerance to antagonism. The range of inhibition of R. solani varied widely in competition with some of the antagonists. © 1979 Birkhäuser Verlag.
Effects of carbonisation conditions on the yield and chemical composition of Acacia and Eucalyptus wood chars
(1992) M. Kumar; R.C. Gupta; T. Sharma
Acacia and Eucalyptus woods were carbonised in the temperature range 400-1200°C using two different heating-cooling cycles, viz. slow and rapid. The yield of chars and their chemical composition was found to be dependent on the carbonisation temperature, heating rate, soaking time and wood species. The char yield gradually decreased with increase in carbonisation temperature and the majority of volatilisation occurred up to 800°C. Slow carbonisation resulted in higher char yield than rapid carbonisation. The char yield from Eucalyptus wood samples was greater than from Acacia wood. The carbon content of Eucalyptus wood char was found to be a little higher than Acacia wood char produced under similar carbonisation conditions, possibly due to relatively higher lignin content of Eucalyptus wood. © 1992.
Experimental production of thyrotoxicosis
(1974) R.C. Gupta; G.C. Prasad; R.S. Wahi; A.K. Tandon; K.N. Udupa
The role of emotional stress in thyrotoxicosis has been studied in female rats exposed to continuous emotional stress for 8 days by keeping them in front of dog cages. Marked epithelial proliferation in the first 2 weeks, followed by lymphocytic infiltration in the next 2 weeks, results in the typical histological picture of thyrotoxicosis. Elevated serum protein bound iodine, T 3 resine uptake and 131I uptake and lowered serum cholesterol level confirm the thyrotoxicosis.
Formation of reproductive bodies by Fusarium udum within Cunninghamella echinulata during parasitism
(1979) R.S. Upadhyay; B. Rai; R.C. Gupta
[No abstract available]
Fusarium udum as a mycoparasite of Mortierella subtilissima
(Martinus Nijhoff/Dr. W. Junk Publishers, 1981) R.S. Upadhyay; Bharat Rai; R.C. Gupta
Fusarium udum was found to be a mycoparasite of Mortierella subtilissima which is a new record. Formation of chlamydospores by F. udum inside M. subtilissima was observed as a result of mycoparasitism. © 1981 Martinus Nijhoff/Dr W. Junk Publishers.
Fusarium udum parasitic on Aspergillus luchuensis and Syncephalastrum racemosum
(Martinus Nijhoff, The Hague/Kluwer Academic Publishers, 1981) R.S. Upadhyay; Bharat Rai; R.C. Gupta
Mycoparasitic behaviour of F. udum on two soil-inhabiting microfungi, Aspergillus luchuensis and Syncephalastrum racemosum, was studied in dual cultures. Fusarium udum coiled and penetrated the host fungi and formed chlamydospores inside their hyphae and reproductive structures. The vegetative hyphae of A. luchuensis showed swellings due to diffusible toxic substances of F. udum in the medium and formed vesicle-like structures. This is the first record of these fungi being hosts of the mycoparasite F. udum. © 1981 Martinus Nijhoff/Dr W. Junk Publishers.
Graphitization study of Indian Assam coking coal
(1995) M. Kumar; R.C. Gupta
X-ray diffraction and true density measurement studies were carried out to investigate the effect of carbonization temperature (up to 2700°C) on the extent of graphitization in Assam coking coal. With increasing carbonization temperature, the crystallite height (Lc) and diameter (La) and true density of the product increased considerably, while the interlayer spacing (d002) was reduced. The net result is that the extent of graphitization increases with increasing carbonization temperature. Carbonization at 2400°C resulted in the formation of product having d002 spacing and true density very close to those of pure graphite, while these properties of the 2700°C carbonized product are somewhat better than those of pure graphite. © 1995.
Hyphal parasitism and chlamydospore formation by Fusarium oxysporum on Rhizoctonia solani
(Kluwer Academic Publishers, 1979) R.C. Gupta; R.S. Upadhyay; Bharat Rai
Hyphal parasitic behaviour of Fusarium oxysporum on Rhizoctonia solani and consecutive changes during this phenomenon have been investigated and studied. The hyphal parasitism was very commonly recorded between the test fungi. During the course of parasitism coiling, penetration, lysis and formation of chlamydospores by F. oxysporum on R. solani were observed. R. solani is a new host record for the mycoparasite F. oxysporum. © 1979 Kluwer Academic Publishers.
Influence of Amoora rohituka on MCF-7 human mammary adenocarcinoma cells in vitro
(1994) T. Rabi; R.C. Gupta; A.K. Gulati
The ethanol extract of Amoora rohituka stem bark showed Cytotoxicity against MCF-7 cell lines derived from human mammary adenocarcinoma with a 50% inhibitory concentration (IC50) of 30 μm/ml, but with no activity against HEp-2 from a tumour of the larynx.
Metabolism and excretion of centbutindole (neuroleptic) in rats after oral administration
(2002) M. Issar; S.K. Singh; K.P. Madhusudanan; B. Mishra; R.C. Gupta
The metabolism and excretion of centbutindole was studied in Sprague-Dawley rats after oral administration. The percentage of dose excreted was monitored over 4 days. Efforts were also directed towards evaluating the stability of centbutindole in various in-vitro biomatrices. Centbutindole was found to be metabolised in rats and only a negligible amount of parent drug was excreted. The percentage of the dose excreted in bile and faeces was 0.2 % and 0.6 %, respectively. No drug was found in urine after oral administration, but after an intravenous dose only 0.0012 % of the dose was eliminated through urine. Two metabolites, dealkylated metabolite and hydroxy metabolite, were identified by ion spray LC/MS/MS, using a combination of parent ion and product ion scanning techniques. The major routes of metabolism of centbutindole include reduction of the carbonyl functional group in the butyrophenone side chain and N-dealkylation of the butyrophenone side chain attached to the pyrazinopyridoindole ring nitrogen at position 2. The hydroxy metabolite was excreted negligibly in bile, although it was present in the form of glucuronide conjugates more in comparison to its free form.
Mucor circinelloides a destructive hyperparasite of Rhizopus nigricans
(Kluwer Academic Publishers, 1978) R.C. Gupta; R.N. Tandon
In vitro studies on hyphal interactions between phyllosphere and phylloplane fungi revealed Mucor circinelloides to be a destructive hyperparasite of Rhizopus nigricans. The mycoparasite penetrated the host hypha and formed sporangiophores and sporangia on different parts of Rhizopus nigricans. © 1978 Dr. W. Junk bv.
Oil cakes as media for growing Catenaria anguillulae Sorokin, a facultative endoparasite of nematodes
(2005) R.C. Gupta; S.S. Vaish; R.K. Singh; N.K. Singh; K.P. Singh
Growth, morphology, visibility of sporangia and colony colour of 10 isolates of Catenaria anguillulae were compared on six media: linseed oil-cake agar, mustard oil-cake agar, neem oil-cake agar, beef extract agar, Emerson agar and YPSS agar with a view to selecting the best growth medium. In general, maximum radial growth of most of the isolates was recorded on linseed oil-cake agar medium, whereas neem oil-cake agar medium supported least growth of all the isolates of C. anguillulae. Linseed oil-cake agar medium also maintained the typical characters of the fungus and clear visibility of morphological details. © Springer 2005.
Pattern and sensitivity of bacterial flora in trachoma
(1999) Vandana Prasad; J.S. Mathur; R.C. Gupta; Sudhir Kumar
This article reports our study of the pattern of bacterial flora in 206 trachomatous conjunctival sacs and 100 controls. The sensitivity pattern of all organisms isolated from the trachomatous conjunctival sacs showed that most of these organisms are sensitive to newer antibiotics such as ciprofloxacin and norfloxacin. Therefore we recommend the use of these effective newer antibiotics rather than conventional topical drugs such as sulfacetamide and tetracycline in treating trachoma.