Browsing by Author "S.K. BHATTACHARYA"

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Brain monoamines during carrageenan‐induced acute paw inflammation in rats
(1988) S.K. BHATTACHARYA; NEETA DAS; P. J. R. MOHAN RAO
Abstract— Paw inflammation was induced in rats by sub‐plantar administration of carrageenan. Significant inflammatory oedema was observed 1 h later and the peak effect was noted between 3–4 h. The oedema was markedly reduced after 12–24 h. Steady state levels of whole brain and hypothalamic monoamines were estimated spectrofluorometrically during the course of the carrageenan‐induced paw inflammation. In addition, the rate of accumulation of the brain 5‐hydroxytryptamine (5‐HT) and noradrenaline (NA) was assessed in clorgyline‐pretreated rats during the inflammation. The whole brain and hypothalamic concentrations of 5‐HT and NA were augmented during the early phase of the inflammation, but fell below control values when peak inflammation was achieved. Thereafter, the monoamine levels tended to normalize by 24 h when the inflammation had virtually subsided. On the contrary, whole brain and hypothalamic dopamine levels remained largely unaffected. The rate of accumulation of brain 5‐HT and NA were enhanced during carrageenan inflammation, indicating that the turnover of these monoamines is augmented during the inflammatory process. The results suggest that acute peripheral inflammation may significantly affect central 5‐HT and noradrenergic activity in rats. 1988 Royal Pharmaceutical Society of Great Britain
CLINICAL STUDY OF POROKERATOSIS: REPORTS OF 10 CASES
(1976) H.S. GIRGLA; S.K. BHATTACHARYA
ABSTRACT: Morphological and histopathological observations made over 4 years of 10 patients with porokeratosis are described. Absence of familial involvement was notable. Association of porokeratosis with tinea cruris, leprosy and epithelioma was seen, and their possible correlation is discussed. Copyright © 1976, Wiley Blackwell. All rights reserved
Effect of centrally administered prostaglandin D2 and some prostaglandin synthesis inhibitors on carrageenan‐induced paw oedema in rats
(1989) S.K. BHATTACHARYA; P. J. R. MOHAN RAO; G. DAS GUPTA
Abstract— The putative modulatory role of central prostaglandins (PGs) on peripheral inflammation has been explored by investigating the effects of intracerebroventricularly (i.c.v.) administered PGD2, the major rodent brain PG, hydrocortisone, a phospholipase A2 inhibitor, and the cyclo‐oxygenase inhibitors, paracetamol and mefenamic acid, on carrageenan‐induced paw inflammation in rats. PGD2 produced a dose‐related inflammation‐augmenting effect, whereas hydrocortisone and the PG synthesis inhibitors, paracetamol and mefenamic acid, induced attenuation of the peripheral oedema. These findings confirm an earlier report from this laboratory which had indicated that central PGs may modulate peripheral inflammation and that conventional anti‐inflammatory agents exert at least part of their effect by inhibiting central PG synthesis. 1989 Royal Pharmaceutical Society of Great Britain
Intracerebroventricularly administered bradykinin augments carrageenan‐induced paw oedema in rats
(1988) S.K. BHATTACHARYA; P. J. R. MOHAN RAO; NEETA DAS; G. DAS GUPTA
Abstract— Intracerebroventricular (i.e.v.) administered bradykinin (2.5 and 5.0 μg/rat) was found to augment carrageenan‐induced acute paw oedema throughout the 4 h post‐carrageenan observation period. The effect was statistically significant with the higher dose. The pro‐inflammatory effect of i.c.v. bradykinin was antagonized following pretreatment with hemicholinium and atropine ethoiodide administered i.c.v., drugs that reduce central cholinergic activity. Similarly, central administration of drugs that inhibit the synthesis of eicosanoids, hydrocortisone, diclofenac and paracetamol, also attenuated the pro‐inflammatory effect of bradykinin. The findings indicate that the inflammation‐promoting effect of centrally administered bradykinin involves the central prostaglandin and cholinergic neurotransmitter systems. 1988 Royal Pharmaceutical Society of Great Britain
NEVUS LIPOMATOSUS CUTANEOUS SUPERFICIALIS
(1975) H.S. GIRGLIA; S.K. BHATTACHARYA
ABSTRACT: Nevus lipomatosus cutaneus superficialis (Hoffman‐Zurhelle) is a distinct clinical entity. A case is reported in which the lesions were large, appeared early in childhood and were linear in distribution along the natal cleft. Copyright © 1975, Wiley Blackwell. All rights reserved
Studies on the effect of physostigmine on experimental cardiac arrhythmias in dogs
(1972) P.K. DAS; S.K. BHATTACHARYA
Experimental cardiac arrhythmias were produced in dogs anaesthetized with pentobarbitone. Ventricular arrhythmias were induced by strophanthin‐K, light petroleum plus adrenaline or coronary ligation procedures. Atrial flutter was induced by an injury‐stimulation technique. The acetylcholine and glycogen concentrations of the atria and ventricles were estimated. Physostigmine pretreatment (0·1 mg/kg) significantly reduced the incidence of ventricular arrhythmias after myocardial ischaemia but had no effect on any of the other arrhythmias. Physostigmine markedly increased the acetylcholine concentrations of atria and ventricles in control dogs, to nearly the same extent. Physostigmine had no effect on ventricular acetylcholine concentrations in dogs treated with strophanthin‐K and light petroleum plus adrenaline but in the coronary ligation group it caused a significant increase in the acetylcholine concentrations of both atria and ventricles, and of atrial acetylcholine only in the injury‐stimulation group. All the arrhythmias produced marked glycogenolysis of both the atria and the ventricles, to nearly the same extent. Although physostigmine produced marked glycogenolysis in the control dogs it significantly inhibited cardiac glycogenolysis after light petroleum plus adrenaline, atrial glycogenolysis after strophanthin‐K‐induced arrhythmias and ventricular glycogenolysis after myocardial ischaemia. There appears to be a possible correlation between the increase in the acetylcholine concentration of the ventricles and anti‐arrhythmic actions of physostigmine, but there is a less clear correlation between changes in the glycogen concentration of ventricles and the anti‐arrhythmic action. 1972 British Pharmacological Society