Browsing by Author "S.S. Dubey"

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Ascorbic acid status in uremics.
(1992) R.G. Singh; A.K. Gupta; S.S. Dubey; Usha; M.R. Sharma
Plasma levels of ascorbic acid (AA) and dehydroascorbic acid (DHA) were estimated in 27 patients of end stage renal failure (ESRF) on standard conservative therapy (group A) and 9 patients of ESRF on maintenance haemodialysis (MHD; group B). Fourteen healthy subjects matched for age and sex served as control (group C). The dietary intake of vitamin C was significantly decreased in group A than in group B compared to control. Similarly, plasma AA was significantly lowered to 0.801 +/- 0.283 mg per cent in group A compared to 1.421 +/- 0.47 mg per cent in control. While it was just lowered to 1.058 +/- 0.272 mg per cent in group B. Although plasma level of DHA was raised to 0.243 +/- 0.486 mg per cent and 0.166 +/- 0.54 mg per cent in groups A and B respectively, the increase was not statistically significant. In our present study, the DHA/AA ratio was found to be inversely proportional to the plasma AA. Further, this ratio has been claimed to be a better indicator of overall reducing atmosphere (i.e., profile of vitamin C) of the body.
Ascorbic acid status of euthyroid patients
(1979) S.S. Dubey; R.P. Singh; K.N. Udupa
[No abstract available]
Ascorbic acid status of hyperthyroid patients
(1976) S.S. Dubey; R.P. Singh; K.N. Udupa
[No abstract available]
Ascorbic acid status of hyperthyroid patients
(1977) S.S. Dubey; R.P. Singh; K.N. Udupa
Controlled studies were conducted to find out the total, reduced and dehydroascorbic acid contents of plasma and thyroid tissue in hyperthyroid patients. Leucocyte ascorbic acid, urinary excretion of total ascorbic acid and ascorbic acid saturation tests were also carried out in order to assess the ascorbic acid status of these patients. It was observed that the plasma content of reduced ascorbic acid and total ascorbic acid were significantly subnormal in hyperthyroid patients whereas the dehydroascorbic acid was comparable with the control values. The urinary excretion of ascorbic acid was found to be lower than the control values. This indicates that in hyperthyroid patients the tissue status of ascorbic acid is poor. Thyroid tissue analysis also showed decreased levels of reduced and total ascorbic acid. However, the dehydroascorbic acid content was comparable with the control.
Ascorbic acid, dehydroascorbic acid and glutathione in liver disease
(1987) S.S. Dubey; G.R. Roy Palodhi; A.K. Jain
[No abstract available]
Erythrocyte membrane stearic to oleic acid ratio in carcinoma of the gallbladder: A preliminary study
(W.B. Saunders Ltd, 1998) Manoj Pandey; Ajay K. Khatri; S.S. Dubey; Amitabh Gautam; Vijay K. Shukla
Aims. The role of erythrocyte membrane stearic to oleic acid ratio (saturation index) as a marker of malignancy is still unclear, though an association has been found in colorectal carcinoma, bronchogenic carcinoma, leukaemia, lymphoma and in hepatic malignancies. This study aims to investigate the role of the saturation index in primary carcinoma of the gallbladder. Methods. This paper describes the results of the stearic to oleic acid ratio determination in 26 subjects with either cholelithiasis or carcinoma of the gallbladder, also including a group of age- and sex-matched controls, using gas chromatography. This is the first report of the saturation index in carcinoma of the gallbladder. Results. A significantly lower saturation index was observed in patients with carcinoma of the gallbladder than with cholelithiasis (t = 2.19, P = 0.043, T= 47, P < 0.05, Wilcoxon P < 0.001, F = 2192.23, P < 0.001; 95% CI 18.45-30.44) and controls (t = 2.5, P = 0.024, T = 36, P < 0.05, F= 10904.11, P < 0.001, Wilcoxon P < 0.001; 95% CI 52.42-63.39). Among the carcinoma patients a further lowering was noted in stage IV disease compared with stage III (T = 6, P < 0.05). Conclusions. These changes are probably due to a marked increase in oleic acid content at the expense of stearic acid. This lowering of the saturation index in carcinoma of the gallbladder is similar to that observed previously in the other malignancies.
Histamine and histaminase levels in the blood
(1977) V. Rai; G.P. Dubey; S.S. Dubey; R.H. Singh; K.N. Udupa
[No abstract available]
Ion-exchangers in radioactive waste management Part XIV: Removal behavior of hydrous titanium oxide and sodium titanate for Cs(I)
(2004) S.P. Mishra; S.S. Dubey; D. Tiwari
The removal behavior of hydrous titanium oxide and sodium titanate for Cs(I) from aqueous solutions by radiotracers was studied. Batch experiments revealed that an increase in Cs concentration (10 -8 to 10 -2 mol .dm -3), temperature (298 to 328 K) and pH (2.50 to 10.20) apparently enhanced the uptake of Cs(I) on hydrous titanium oxide whereas a high degree of uptake of Cs(I) on sodium titanate was almost unaffected by a change in adsorption temperature (298 to 328 K) and pH (2.50 to 10.20). Both systems follow Freundlich adsorption isotherm. Uptake of Cs(I) on hydrous titanium oxide obeys first order rate law. According to thermodynamic data the uptake is endothermic and apparently 'irreversible' in nature.
Removal behavior of Babool bark (Acacia nilotica) for submicro concentrations of Hg2+ from aqueous solutions: A radiotracer study
(2005) S.S. Dubey; Ram Krishna Gupta
The uptake behavior of Babool bark (Acacia nilotica) for the micro to trace levels of Hg2+ from aqueous solutions has been carried out in batch equilibrium experiments, employing a 'radiotracer technique'. A high level of uptake of metal ions on the solid surface occurs within ca. 2 h of contact time. The increase of sorptive concentration (10-7 to 10-2 M), temperature (303-333 K), and pH (3-10) favored the removal process of ions. The percentage adsorption increases from 54.3 to 91.3% with an increase in dilution of sorptive solution from 10-2 to 10-7 M. First order uptake of Hg2+ followed the Freundlich and Dubinin-Radushkevich (D-R) isotherms for the entire range of adsorptive concentration studied. Temperature dependence data show that this process is endothermic in nature. Desorption experiments further confirm the irreversibility of the sorption process as no significant desorption took place in the bulk concentration of the adsorptive. © 2004 Elsevier B.V. All rights reserved.
Removal of cesium ions from aqueous solution by polyaniline: A radiotracer study
(2005) R.K. Gupta; S.S. Dubey
The present work deals with the study of uptake behavior of cesium ions by polyaniline applying a radiotracer technique. The parametric study reveals that the increase of adsorbate concentration (10-8 to 10-3 mol∈dm-3) and temperature (303 to 333 K) enhances the removal of the ions and from thermal and kinetic data it is inferred that the adsorption of cesium ions follows first order rate law, obeys Freundlich isotherm and is endothermic in nature. The radiation stability of polyaniline was also investigated by exposing it to a 11.1 GBq (Ra-Be) source associated with gamma dose of 1.72 Gyh-1. © Springer 2005.
Removal of mercury ions from aqueous solutions by composite of polyaniline with polystyrene
(2004) R.K. Gupta; R.A. Singh; S.S. Dubey
Radiotracer technique has been used to study the removal of Hg(II) ions from aqueous solutions by composite of polyaniline with polystyrene. This study reveals that the increase of adsorbent concentration (10-8-10-3 M) and temperature (293-333 K) enhances the removal of Hg(II) ions. Concentration-dependence data agree well with the Freundlich isotherm. Thermochemical data show that this process is endothermic in nature. The radiation stability of the composite was also investigated by exposing it to a 11.1-GBq (Ra-Be) source associated with γ dose of 1.72 Gy h-1. Irradiation has practically no effect on the adsorption capacity of the composite. Desorption experiments show that the process of adsorption of mercury ions is almost irreversible and chemisorptive in nature. © 2003 Elsevier B.V. All rights reserved.
Serum LCAT and lipoprotein-Transport cholesterol in hyperthyroid patients
(Springer India, 1992) A. Dasgupta; J.K. Agarwal; S.S. Dubey
The aim of the present study was to evaluate the serum levels of lecithin cholesterol acyl transferase and lipoprotein cholesterol in hyperthyroid patients. The serum levels of total cholesterol and triacylglycerols were also determined in order to assess the lipid status of these patients. It was observed that serum content of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density liproprotein cholesterol (HDL-C) were significantly lower (P<0.001) in these patients whereas serum triacylglycerols (Tg.) and very low density lipoprotein cholesterol (VLDL-C) (P>0.05) did not show any significant change as compared to control values. However, the serum level of lecithin cholesterol acyl transferase (LCAT) was significantly higher (P<0.001) in these patients. It is concluded that an increased LCAT activity plays a significant role in regulating lipoprotein cholesterol levels in hyperthyroid patients. © 1992 Association of Clinical Biochemists of India.
Serum malondialdehyde and lipid profile in bronchial asthma
(2002) H.D. Khanna; S.S. Dubey; R. Khanna; J.K. Mishra
The aim of present study was to evaluate serum levels of malondialdehyde (MDA) and lipoprotein transport cholesterol in bronchial asthma patients. The serum levels of total cholesterol and triacylglycerol were also determined in order to assess the lipid status of these patients. It was observed that serum contents of total cholesterol, low density lipoprotein cholesterol and MDA were significantly higher in both the group of patients (younger and elderly group) suffering from bronchial asthma. Moreover serum triacylglycerol, very low density lipoprotein cholesterol and high density lipoprotein cholesterol did not show any significant change as compared to control values. However the TC/HDL-C and LDL-C/HDL-C ratios were significantly higher in all these patients. Altered cholesterol ratios and serum MDA level in these patients have been related to increased risk of complications.
Studies of serum components in myopic subjects
(1973) A.N. Mehrotra; E. Vaithilingam; S.S. Dubey
Biochemical studies of serum phosphate, serum calcium and serum protein were conducted on 28 cases of adolescent myopia. It was observed that while 75% of them showed protein deficiency, a majority of them were found to have high values of serum phosphate.
The effect of vitamin A and cortisone on ascorbic acid content in the aqueous humor
(1982) K.S. Mehra; A. Kumar; S.S. Dubey; G.R. Palodhi
The effect of vitamin A and cortisone drops on ascorbic acid content of the aqueous humor was studied in 24 albino rabbits (48 eyes). After administration of cortisone for 7 and 14 days, there was a statistically significant lowering of the ascorbic acid concentration in the aqueous humor. Further, after addition of vitamin A drops locally, a significant rise in ascorbic acid content of the aqueous humor was noted.
Topical cholesterol in clofazimine induced ichthyosis
(1994) S.S. Pandey; S.S. Kushwaha; S.S. Dubey; S. Singh
Topical application of 10% cholesterol in petrolatum significantly (P < 0.05) controlled the development of ichthyosis in 62 patients taking 100 mg clofazimine daily for a period of 3 months. However, topical cholesterol application did not affect the lowering of serum cholesterol induced by oral clofazimine. Probable mechanism of action is being discussed.