Browsing by Author "Satyendra Kumar Singh"

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A case report of donovanosis in HIV-positive female
(Wolters Kluwer Medknow Publications, 2024) Niharika Kumari; Aanchal Agarwal; Atul Mohan; Satyendra Kumar Singh
Donovanosis is a chronic granulomatous ulcerative sexually transmitted infection caused by Klebsiella (Calymmatobacterium) granulomatis. A 39-year-old female patient with underlying HIV infection presented to the department of dermatology outpatient department with a painless ulcer over the left labia majora for 3 months. Histopathological examination revealed histiocyte which contains granular material resembling coccobacilli and Giemsa staining was positive for Donovan bodies. She was treated with doxycycline 100 mg twice daily and azithromycin 1 g once weekly for 3 weeks and further azithromycin 1 g weekly for the next 9 weeks till complete healing of the lesion. Due to the rarity of this condition in our region, we present this case of donovanosis in an HIV-positive female patient. © 2024 Copyright:
A rare case of nevoid psoriasis
(2013) Satyendra Kumar Singh; Tulika Rai
[No abstract available]
Allopurinol induced granuloma annulare in a patient of lepromatous leprosy
(2013) Satyendra Kumar Singh; Kajal Manchanda; Aakash Amar Bhayana; Anurag Verma
Granuloma annulare (GA) is a benign, inflammatory dermatosis involving dermis or subcutis with unknown etiology and poorly understood pathology. GA has characteristic histological features of necrobiosis, granuloma formation and abundant mucin deposition. Various predisposing factors, systemic diseases and drugs have been implicated in the etiology. We hereby describe a case of 70 year old male who was a known case of lepromatous leprosy, taking multidrug therapy for 6 months presented with multiple discrete, annular, firm, non tender, smooth surfaced skin colored papular lesions ranging in size from 0.5-1 cm over back for 1 month. There was past history of intake of allopurinol for hyperuricemia which was started 1 year back. There was history of similar lesions 6 months back which healed within 1 month of stopping allopurinol and he started taking the drug for the past 4 months on his own without any medical advice. Histopathological examination showed superficial and deep perivascular lymphocytic infiltrate with numerous histiocytes scattered in the intersititum of reticular dermis and abundant mucin in between the histiocytes. Allopurinol was implicated as an etiological agent and dramatic improvement was seen after stopping the drug for a period of 4 weeks. Naranjo's algorithm showed a probable association with a score of 6. Thus the final diagnosis of allopurinol induced generalised interstitial granuolma annulare was made. Patient was advised to continue antileprotic drugs, low purine diet and avoid allopurinol intake.
Association of type 2 lepra reaction with filariasis and malaria
(Medknow Publications, 2015) Satyendra Kumar Singh; Taniya Sharma; Gopal Nath; Tej Bali Singh; Manoj Kumar Shrivastava
[No abstract available]
Authors’ reply
(Scientific Scholar, 2022) Satyendra Kumar Singh; Sermili Rini Singnarpi
[No abstract available]
Awareness and Knowledge of Sexually Transmitted Infections and its Associated Factors among Clinically Suspected Cases Attending a Tertiary Care Hospital in Eastern Uttar Pradesh
(Tehran University of Medical Sciences, 2024) Prince Kumar Patel; Tej Bali Singh; Satyendra Kumar Singh; Vikash Singh Patel; Swati Singh
Introduction: Sexually transmitted infections (STIs) include a range of clinical syndromes that may be acquired/transmitted from one individual to another through sexual activity. This study aimed to determine the awareness and knowledge of sexually transmitted infections and its associated factors among clinically suspected cases. Methods: A hospital-based cross-sectional study design was used among 194 STIs patients between aged 15 to 60 years from a tertiary care hospital during August 2022 to March 2023. Data were collected through self-administered structured schedule. A multiple logistic regression analysis was used to identify factors associated with awareness and knowledge of STIs. Results: The proportion of respondents with good awareness and knowledge about STIs was 62% and 50% respectively. Respondents with poor awareness and poor knowledge of STIs were found to be more likely to engage in informal treatment care (AOR = 7.39, 95% CI [2.14-25.52] P = 0.002),) and (AOR = 1.21, 95% CI [1.34-4.30], P = 0.021). Place of residence, educational status, occupation, type of treatment care was found to be significantly associated with awareness of STIs and type of treatment care, referral status, delay in seeking treatment were found to be significantly associated with knowledge of STIs. Conclusion: The current findings show that the knowledge level on STIs has slightly increased compared to previous studies, but it was still unsatisfactory. The existing education programs in the country should be enhanced, by conveying more information on STIs. © 2024 Tehran University of Medical Sciences.
Awareness of sexually transmitted infection (STI)/reproductive tract infections (RTI) and HIV/AIDS in STI/RTI - Affected married women of rural areas of Varanasi district, Uttar Pradesh: A cross-sectional study
(Medknow Publications, 2015) Swati Singh; Satyendra Kumar Singh; Tej Bali Singh
[No abstract available]
Co-infection of hepatitis B virus and hepatitis C virus with human immunodeficiency virus infection: A cross-sectional study
(Medknow Publications, 2016) Satyendra Kumar Singh; Swati Singh; Gopal Nath; Manoj Kumar Srivastava
[No abstract available]
Comparison of efficacy of platelet-rich plasma therapy with or without topical 5% minoxidil in male-type baldness: A randomized, double-blind placebo control trial
(Wolters Kluwer Medknow Publications, 2020) Satyendra Kumar Singh; Vijay Kumar; Tulika Rai
Background: Male-type baldness is a common chronic hair loss disorder among males. Male type baldness is characterized by stepwise miniaturization of the hair follicle, due to alteration in the hair cycle dynamics, leading to transformation of the terminal hair follicle into a vellus one. Platelet-rich plasma (PRP) seems to be a new technique which may improve hair regrowth. We planned a randomized, double-blinded placebo control trial to see the efficacy of PRP with and without topical minoxidil and to compare with placebo and standard treatment. Materials and Methods: The study design was a randomized, double-blind placebo control trial. The sample size was calculated, and randomization was done. Patients with male type baldness were allocated into four groups; first group topical minoxidil only, the second group PRP with minoxidil, the third group normal saline (NS), and fourth group PRP only. Interventions were done monthly for 3 months and patients were followed up for the next 2 months. Effects of interventions were assessed by hair density, patient self-assessment, and clinical photography. Results: A total of 80 patients were included. The maximum improvement was found in PRP with minoxidil group. Increase in hair density (in descending order) was PRP with minoxidil group, PRP-alone group, minoxidil-alone group, while a decrease in hair density was found in NS group, after 5 months. The maximum patient satisfaction was found in PRP with minoxidil group followed by (in descending order), PRP-alone group, minoxidil-alone group, and NS group. Limitation: Long-term follow up of patients was not done. Hair counts and hair thickness estimation were not estimated. Conclusion: In our study, we found PRP with topical minoxidil is more effective than PRP alone and topical minoxidil alone. © 2020 Wolters Kluwer Medknow Publications. All rights reserved.
Disseminated cutaneous fusariosis in human immunodeficiency virus-infected patient and dramatic response with oral itraconazole
(Wolters Kluwer Medknow Publications, 2018) Indu Kumari; Satyendra Kumar Singh; Rishabh Kumar Chauhan; Satyendra Kumar Kaushal
Fusarium species are known to cause disseminated cutaneous lesions in immunocompromised patients. Some cases of fusariosis are reported in patients infected with the human immunodeficiency virus. There are two reports in such patients with systemic comorbidities like lymphoma, neutropenia and infective port-a-catheter. Another reported patient had systemic fusariosis, without skin involvement. Diagnosis and treatment of cutaneous fusariosis is difficult and resistance to antifungals is a problem. Our patient was at an advanced human immunodeficiency virus infection stage with disseminated cutaneous fusariosis, without any systemic involvement, who responded completely to oral itraconazole. © 2018 Medknow Publications. All rights reserved.
Familial syringomas
(2013) Satyendra Kumar Singh; Tulika Rai
[No abstract available]
Familial woolly hair: A rare entity
(2012) Satyendra Kumar Singh; Kajal Manchanda; Anand Kumar; Anurag VerM.A.
[No abstract available]
Finger nail pitting in psoriasis and its relation with different variables
(2013) Satyendra Kumar Singh
Incidence of pitting, vary considerably in different types of psoriasis. In clinical practice, toe nail examination is inconvenient. There are inadequate studies which show relation of nail pitting with duration and severity of the disease. The objective was to examine the incidence of finger nail pitting in all types of cutaneous psoriasis and its relation with different variables. This is a clinico-epidemiological study. A careful clinical examination of finger nails was done in day time. Severity of disease was calculated by psoriasis area severity index (PASI). Statistical analysis was done using Microcomputer statistics software (MSTAT). In study group, 621 patients and in control group 350 people were taken. Finger nail pitting was present in 37% (total number was < 20 in 17%; 20-60 in 8% and > 60 in 12%) in study group. In control group, it was present in 10% (in all cases total number was < 20). In < 1 year duration group, pitting was present in 32% of cases, while in > 1 year duration group it was 40.5%.In mild psoriasis, pitting was present in 34.2%, while in severe cases it was 47.6%. Finger nail pitting is an important nail finding in psoriasis and its incidence increases with duration and severity of disease.
In vitro susceptibility of dermatophytes to oral antifungal drugs and amphotericin B in Uttar Pradesh, India
(Wolters Kluwer Medknow Publications, 2019) Satyendra Kumar Singh; Dheeraj Kumar Patwa; Ragini Tilak; Arghya Das; Tej Bali Singh
Background: Dermatophytosis is a major public health problem in our country. Although resistance to conventional oral and topical antifungal agents is being increasingly encountered, the sensitivity pattern of dermatophytes has not been systematically analysed. Aims: We aimed to determine the sensitivity pattern of dermatophyte isolates to amphotericin B and six oral antifungal drugs. Materials and Methods: Patients with dermatophytosis attending the outpatient department of dermatology were enrolled in the study. Samples were collected for mycological examination and in vitro antifungal sensitivity testing was done by broth microdilution as per the Clinical and Laboratory Standard Institute M38-A standards. Results: A total of 804 patients were enrolled. Specimens from 185 patients (23%) were both KOH and culture positive, and 44 of these isolates (41 Trichophyton mentagrophytes and 3 Trichophyton rubrum) were subjected to sensitivity testing. Minimum inhibitory concentrations (MIC) of itraconazole, ketoconazole, voriconazole and amphotericin B were comparable. The median MIC to fluconazole was higher than the other tested drugs. Dermatophytes were most susceptible to ketoconazole and voriconazole, followed by itraconazole, amphotericin B, fluconazole and griseofulvin. A high incidence of resistance was found to terbinafine and the difference was statistically significant in comparison to fluconazole, itraconazole, voriconazole, ketoconazole (P = 0.001) and griseofulvin (P = 0.003). The strains were more sensitive to amphotericin B as compared to griseofulvin (P = 0.02) and terbinafine (P < 0.001). Limitations: This was a hospital-based study and may not reflect the true pattern in the community. Only a few of the isolates were selected for study. The clinical response of patients, whose isolates were studied for in vitro sensitivity of the antifungals, was not studied. Conclusions: The sensitivity pattern of dermatophytes to various antifungals including amphotericin B, ketoconazole, voriconazole and itraconazole were determined. The studied isolates were least susceptible to terbinafine. © 2019 Indian Journal of Dermatology, Venereology and Leprology.
Metastatic testicular cancer in a patient with arsenical keratosis
(Pakistan Association of Dermatologists, 2013) Satyendra Kumar Singh; Farzeen Nasir; Tulika Rai
Arsenicosis is a multisystem disorder, with many cutaneous features. The cutaneous manifestations take the form of pigmentary changes, hyperkeratosis, and skin cancers (Bowen's disease, squamous cell carcinoma, and basal cell carcinoma). It is a known carcinogen and there is association between chronic arsenic exposure and malignancy of bladder, lung, liver, kidney and other visceral malignancies. Our patient came from an endemic area where levels of arsenic are high in drinking water and had features of arsenical keratosis for past fifteen years along with metastatic testicular cancer at the time of presentation. Arsenic exposure may increase the risk of testicular cancer.
Multiplex nested polymerase chain reaction targeting multiple genes for the detection of Neisseria gonorrhoeae and Chlamydia trachomatis in genitourinary specimens
(Wolters Kluwer Medknow Publications, 2019) Ketan Priyadarshi; Pradyot Prakash; Anjali Rani; Satyendra Kumar Singh
Objectives: The objective of this study was to design and evaluate a novel multiplex nested polymerase chain reaction (PCR) protocol for simultaneous detection of Neisseria gonorrhoeae and Chlamydia trachomatis in genitourinary specimens obtained from symptomatic patients clinically suspected of sexually transmitted infections (STIs), targeting two different genes each for these pathogens. Materials and Methods: A total of 116 genitourinary specimens were collected from men (n = 12) and women (n = 104). Direct microscopy, culture isolation, and antimicrobial susceptibility testing for N. gonorrhoeae were performed. Multiplex nested PCR was performed on clinical samples using novel designed primers targeting porA pseudogene and opa gene of N. gonorrhoeae and momp gene and cryptic plasmid of C. trachomatis simultaneously. DNA sequence analysis of nested PCR amplicons for each of four gene targets was carried out for the validation of in-house designed primers and PCR protocol. Results: A total of 51.72% (60/116) patients were detected to have either of the two STIs. About 35.35% (41/116) of patients were positive for C. trachomatis and 33.62% (39/116) for N. gonorrhoeae by employing multiplex nested PCR. Coinfection with N. gonorrhoeae and C. trachomatis was detected in 17.24% (20/116) patients. 31.5% endocervical swabs (n = 54), 64.4% speculum-assisted high vaginal swabs (n = 45), and 80% self-collected vaginal swabs (n = 5) were detected positive for either of two STIs. Conclusions: The multiplex nested PCR protocol designed and employed in the present study may be used in the diagnosis and management of both symptomatic as well as asymptomatic cases of N. gonorrhoeae and C. trachomatis, particularly among high-risk groups. © 2019 Indian Journal of Sexually Transmitted Diseases and AIDS.
Orofacial granulomatosis affecting lip and gingiva in a 15-year-old patient: A rare case report
(Wolters Kluwer Medknow Publications, 2015) Monika Bansal; Nootan Singh; Shashikant Patne; Satyendra Kumar Singh
Orofacial granulomatosis (OFG) is a rare disorder affecting the orofacial region, and clinically characterized by diffuse, nontender, soft to firm, painless swelling restricted to one or both lips and intraoral sites such as tongue, gingiva and buccal mucosa. Histologically, OFG is characterized by noncaseating granulomatous inflammation. The early diagnosis of OFG is essential for the better prognosis of the lesion. Delay in diagnosis of OFG results into formation of indurated and permanent swelling of the lip that not only compromises esthetic appearance but also causes impairment in function such as speaking and eating. Early diagnosis of OFG is challenging to the health care professionals due to clinical and histological resemblance to other chronic granulomatous disorders. Thus, dentists may act as a first person to diagnose the lesion and play an important role in the multidisciplinary treatment of granulomatous disorders. Here, we present a case of OFG affecting lips and gingiva in a 15-year-old patient without any identifiable systemic or local causes.
PhotoDermDiagnosis multiple umbilicated papulonodular lesions in an immunocompetent lady
(2013) Satyendra Kumar Singh; Tulika Rai; Taniya Sharma; Anand Prabhu
[No abstract available]
Prevalence of pruritus in psoriatic skin lesions and its relations to different variables
(Pakistan Association of Dermatologists, 2014) Satyendra Kumar Singh
Objective: To examine the prevalence of itching in psoriatic skin lesions and its relation with different variables. Methods: A simple questionnaire and a verbal four point intensity scale were used. Severity of disease was calculated by using Psoriasis Area Severity Index (PASI). Results: Six hundred and fourteen patients of psoriasis were examined in which majority were chronic plaque type. Pruritus was present in 79% of the patients, and was severe in 34%; moderate in 15% and mild in 29%. Conclusion: Pruritus was common in chronic plaque psoriasis. It was more severe in more severe type of psoriasis and was more common in females in comparison to males. But there is no difference between pediatric and adult psoriasis.
Prevalence of pruritus in psoriatic skin lesions and its relations to different variables
(2013) Satyendra Kumar Singh
Objective: To examine the prevalence of itching in psoriatic skin lesions and its relation with different variables. Patients and methods: A simple questionnaire and a verbal 4-point intensity scale were used. Severity of disease was calculated by using Psoriasis Area Severity Index (PASI). Results Six hundred and fourteen patients of psoriasis were examined in which majority were chronic plaque type. Pruritus was present in 79% of the patients, and was severe in 34%; moderate in 15% and mild in 30%. Conclusion: Pruritus was common in chronic plaque psoriasis, female patients and those with more severe disease. Itching was more severe in more severe type of psoriasis. It was more common in females in comparison to males. But there was no difference between pediatric and adult psoriasis.