Browsing by Author "Shilpa G. Patil"

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Evaluation of antidepressant activity of three dosages forms of Guduchi (Tinospora Cordifolia) on experimental animal model of forced swim test
(Nova Science Publishers, Inc., 2020) Shilpa G. Patil; Anand K. Chaudhary
In the field of psychopharmacology many of Ayurvedic dosage forms are being researched for their antidepressant effect. Guduchi is a well-known Medhya Rasayan well explained in Ayurveda classics. Aim:To evaluate the antidepressant effect of three dosages forms of Guduchi (Guduchi Satva, Ghana and Churna) using behavioral despair test in depression. Settings and Design: Comparative preclinical study. Materials and Methods: Guduchi Satva, Ghana andChurna was prepared using standard operating procedure, physicochemically analyzed and assessed. Forced Swim Test (FST) model with Charles-Foster albino rats were used to assess antidepressant activity.Adult Charles-Foster albino rats of either sex divided into five groups which were given carboxymethyl cellulose 0.1%, imipramine 10mg/kg (standard antidepressant), Guduchi Satva 112.5mg/kg, Ghana 45mg/kg and Churna 180mg/kg, respectively, for 21 days. Statistical Analysis:A statistical analysis was done by one-way ANOVA test followed by Tucky and Kramer multiple comparison tests using Graph Pad Prism 6. P < 0.05 was considered significant. Result and Conclusion:Guduchi Satva and Ghana significantly reversed the sub-acute stress-induced alterations in behavioral parameters FST. Guduchi Satva and Ghana as compared to Guduchi Churna found to be having antidepressant activity in experimental animals in reduction of duration of immobility. Thus, these formulations can be used in prevention and treatment of depression. © 2020 Nova Science Publishers, Inc. All rights reserved.
Unexplored therapeutic treasure of Himalayan sea buckthorn berry: An opportunity for rejuvenation applications in Ayurveda
(BRNSS Publication Hub, 2016) Shilpa G. Patil; Anand K. Chaudhary
Ayurveda captured almost all herbs in its indications for therapeutics from the period of Vadas. More than 700 plants are discussed elaborately in various classics of Ayurveda of different periods. However, it seems that here is a missing link about sea buckthorn alias Amleech (Hippophae rhamnoides family Elaeagnaceae). This review article is all about morphological characteristic, properties, active constituents, therapeutic spectrum, cosmetic value, nutraceutical value of the plant and its uses for the well-being of humanity. Our objectives are to make this plant beneficial to all humanity as per doctrines of Ayurveda pharmaceutics and therapeutics. We had have searched the available research papers, textbooks, and reference books and summarizes the results related to various properties of sea buckthorn and also emphasizes the aspects that warrant future research in India establishing its activity and utility in preventing diseases related to skin, liver, gastrointestinal, and even cancer. Contemporary researches are indicatives of its various therapeutic properties due to its constituent chemistry such as flavonoids, carotenoides, polyunsaturated fatty acids, vitamins , minerals, Omega 3, 6, 9 and rarest Omega 7 and about 190 bioactive compounds. We can expect many scientific evidence supporting the benefits of the sea buckthorn to maintain health and to cure the diseases by rationalizing it in proper Ayurvedic dosages form for this plant. © 2016 BRNSS Publication Hub. All rights reserved.