Evaluation of antidepressant activity of three dosages forms of Guduchi (Tinospora Cordifolia) on experimental animal model of forced swim test

Abstract

In the field of psychopharmacology many of Ayurvedic dosage forms are being researched for their antidepressant effect. Guduchi is a well-known Medhya Rasayan well explained in Ayurveda classics. Aim:To evaluate the antidepressant effect of three dosages forms of Guduchi (Guduchi Satva, Ghana and Churna) using behavioral despair test in depression. Settings and Design: Comparative preclinical study. Materials and Methods: Guduchi Satva, Ghana andChurna was prepared using standard operating procedure, physicochemically analyzed and assessed. Forced Swim Test (FST) model with Charles-Foster albino rats were used to assess antidepressant activity.Adult Charles-Foster albino rats of either sex divided into five groups which were given carboxymethyl cellulose 0.1%, imipramine 10mg/kg (standard antidepressant), Guduchi Satva 112.5mg/kg, Ghana 45mg/kg and Churna 180mg/kg, respectively, for 21 days. Statistical Analysis:A statistical analysis was done by one-way ANOVA test followed by Tucky and Kramer multiple comparison tests using Graph Pad Prism 6. P < 0.05 was considered significant. Result and Conclusion:Guduchi Satva and Ghana significantly reversed the sub-acute stress-induced alterations in behavioral parameters FST. Guduchi Satva and Ghana as compared to Guduchi Churna found to be having antidepressant activity in experimental animals in reduction of duration of immobility. Thus, these formulations can be used in prevention and treatment of depression. © 2020 Nova Science Publishers, Inc. All rights reserved.