Browsing by Author "Tulika Rai"

Now showing 1 - 20 of 26

A 17-year-old male presenting with multiple hyperpigmented macules over right side of chest in zosteriform pattern
(IP Innovative Publication Pvt. Ltd., 2022) Tulika Rai; Atul Mohan; Mohammad Hamza Ansari; Deeksha Goyal
Lichen planus pigmentosus (LPP) is a variant of lichen planus. It is characterized by small black, brown macules, on sun exposed areas like face, neck, upper extremities and trunk. Lesions are insidious in onset with gradually progressive course. Few variants have been reported like LPP inversus, localized LPP, linear LPP, zosteriform LPP and LPP of oral mucosa etc. Here, we present a case of zosteriform LPP in a young adolescent male, which is a rare presentation. © 2022 Innovative Publication, All rights reserved.
A 27-Year-Old Man with Multiple, Skin-Colored Nodules in a Segmental Distribution on the Right Side of the Face
(Wolters Kluwer Medknow Publications, 2022) Tulika Rai; Vandana Yadav; Neeraj Dhameja; Atul Mohan
[No abstract available]
A case of congenital erythropoietic porphyria
(Pakistan Association of Dermatologists, 2017) Tulika Rai; Prakriti Shukla
Congenital erythropoietic porphyria (CEP) is a rare form of porphyria. It is an autosomal recessive disorder, which results from deficiency of enzyme uroporphyrinogen III cosynthase (or uroporphyrinogen III synthase). Due to the impaired function of this enzyme, excessive amounts of particular porphyrins accumulate, particularly in the bone marrow, plasma, red blood cells, urine, teeth, and bones. Due to photosensitivity, after exposure to light, the photo-activated porphyrins in the skin cause bullae (blistering) that often get infected. These infected lesions can lead to scarring, bone loss, and deformities. The hands, arms, and face are the most commonly affected areas. We report a 6-year-old male child presenting with CEP. © 2017 Pakistan Association of Dermatologists.
A case of linear porokeratosis
(Wolters Kluwer Medknow Publications, 2023) Tulika Rai; Mohammad Hamza Ansari
[No abstract available]
A Case of Multiple Gastrointestinal Polyps, Cutaneous Manifestations, and Nail Dystrophy
(Wolters Kluwer Medknow Publications, 2024) Tulika Rai; Neeraj Garg; Rajendra Kumar Mahawar; Sagnik De
[No abstract available]
A Case of Papular Elastorrhexis in a Young Female
(Wolters Kluwer Medknow Publications, 2022) Tulika Rai; Anisha Najeeb; Prasanna Jha; Anu Jain
[No abstract available]
A case of psoriatic arthritis with severe deformities resembling rheumatoid arthritis
(2013) Manish Bansal; Tulika Rai
Psoriatic arthritis (PsA) is a chronic and inflammatory arthritis that occurs in association with skin psoriasis. The prevalence of psoriasis in the general population is about 1-3%,1 2 and about 6-42% of patients with psoriasis develop PsA. Inflammatory joint disease with psoriatic skin and nail changes with a negative serological test for rheumatoid factor suggests the diagnosis of psoriatic arhritis. We present a case of fifty-five year old male who had severe, deforming arthritis mimicking rheumatoid arthritis who later on developed chronic plaque psoriasis.
A rare case of nevoid psoriasis
(2013) Satyendra Kumar Singh; Tulika Rai
[No abstract available]
Comparison of efficacy of platelet-rich plasma therapy with or without topical 5% minoxidil in male-type baldness: A randomized, double-blind placebo control trial
(Wolters Kluwer Medknow Publications, 2020) Satyendra Kumar Singh; Vijay Kumar; Tulika Rai
Background: Male-type baldness is a common chronic hair loss disorder among males. Male type baldness is characterized by stepwise miniaturization of the hair follicle, due to alteration in the hair cycle dynamics, leading to transformation of the terminal hair follicle into a vellus one. Platelet-rich plasma (PRP) seems to be a new technique which may improve hair regrowth. We planned a randomized, double-blinded placebo control trial to see the efficacy of PRP with and without topical minoxidil and to compare with placebo and standard treatment. Materials and Methods: The study design was a randomized, double-blind placebo control trial. The sample size was calculated, and randomization was done. Patients with male type baldness were allocated into four groups; first group topical minoxidil only, the second group PRP with minoxidil, the third group normal saline (NS), and fourth group PRP only. Interventions were done monthly for 3 months and patients were followed up for the next 2 months. Effects of interventions were assessed by hair density, patient self-assessment, and clinical photography. Results: A total of 80 patients were included. The maximum improvement was found in PRP with minoxidil group. Increase in hair density (in descending order) was PRP with minoxidil group, PRP-alone group, minoxidil-alone group, while a decrease in hair density was found in NS group, after 5 months. The maximum patient satisfaction was found in PRP with minoxidil group followed by (in descending order), PRP-alone group, minoxidil-alone group, and NS group. Limitation: Long-term follow up of patients was not done. Hair counts and hair thickness estimation were not estimated. Conclusion: In our study, we found PRP with topical minoxidil is more effective than PRP alone and topical minoxidil alone. © 2020 Wolters Kluwer Medknow Publications. All rights reserved.
Comparison of sensitivities of skin prick and intradermal tests with oral rechallenge test: A prospective interventional hospital-based study
(Wolters Kluwer Medknow Publications, 2021) Satyendra Singh; Ayushi Bohara; Tulika Rai
Background: Identification of culprit drug causing adverse cutaneous drug reactions may not be possible clinically due to the intake of more than one drug. Aim: To compare the sensitivity of skin tests with gold standard oral rechallenge test to detect adverse cutaneous drug reactions. Materials and Methods: This is a prospective interventional hospital-based study of patients with adverse cutaneous drug reactions attending the outpatient department of dermatology and venereology at a tertiary care center over a 12-month period. Skin prick tests, intradermal tests, and oral rechallenge tests were performed in these patients and their sensitivities were compared. The data of quantitative nature is presented in mean and standard deviation, and categorical variables are presented in number and percentage. The sensitivity of skin tests is compared with the gold standard oral rechallenge test. Results: A total of 49 patients with adverse cutaneous drug reactions were evaluated. Clinical spectrum of adverse cutaneous drug reactions ranged from mild to severe, with fixed drug eruption being the commonest (55.1%) followed by maculopapular exanthem (32.7%). The highest incidence was with fluoroquinolones (43.8%) followed by nonsteroidal anti-inflammatory drugs. Fluoroquinolones were the major cause of fixed drug eruption followed by nonsteroidal anti-inflammatory drugs. The sensitivity of skin prick test and intradermal tests were 49% and 73%, respectively and the difference was highly significant (P < 0.001). The difference in sensitivity in skin prick test versus oral rechallenge test and intradermal test versus oral rechallenge test was also highly significant (P < 0.001). Limitations: Small sample size was a major limitation. Histopathological examinations and human leukocyte antigen associations could not be done. Conclusion: Predominant causative drugs were fluoroquinolones followed by nonsteroidal anti-inflammatory drugs. Sensitivities of skin prick test and intradermal test were quite good and these skin tests should be performed before oral rechallenge test in cases of adverse cutaneous drug reactions. © 2021 Wolters Kluwer Medknow Publications. All rights reserved.
Dermatological Manifestations in Lower Limb Swelling
(Springer Nature, 2022) Tulika Rai
There can be multiple causes of lower limb edema. From the perspective of a dermatologist, there are limited conditions that can present with lower limb swelling. The causes may be broadly classified into infectious causes, eosinophilic cellulitis, pseudocellulitis, eczema, thyroid dermopathy, drugs, and malignancies. Among the infectious causes, bacterial infections and fungal infections may present with localized, unilateral lower limb edema. Cellulitis is one of the common bacterial skin and soft tissue infections which can present to a dermatologist. Timely diagnosis and proper management in such cases are very important for optimal patient care. Certain conditions can mimic cellulitis like eosinophilic cellulitis and pseudocellulitis. Eosinophilic cellulitis should be suspected if there is pruritus associated with an erythematous swelling that does not respond to antibiotics. Pseudocellulitis can also mimic cellulitis in patients who are on chemotherapy. Mycetoma may also present with unilateral lower limb swelling. It presents as a localized, lower limb swelling with draining sinuses and may involve deeper tissues and bone. It is a slow-growing lesion that can be caused by different species of fungus and bacteria. It is further classified into eumycotic mycetoma or actinomycetoma on the basis of causative organism. Irritant contact dermatitis and allergic contact dermatitis can also present with lower limb swelling. A detailed history will aid in diagnosis. Patient presents with eczematous lesions with oozing, vesiculation, scaling, fissuring, or lichenification depending upon the stage of eczema, whether it is acute, subacute, or chronic. Beetle’s dermatitis, in some cases, may also present with localized lower limb swelling. Thyroid dermopathy can also present with lower limb edema, and the diagnosis is often missed by the treating physician. A high index of suspicion will clinch the diagnosis. Malignancies and drug reactions will be discussed in separate chapters. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022.
Epitope imprinting of Mycobacterium leprae bacteria via molecularly imprinted nanoparticles using multiple monomers approach
(Elsevier Ltd, 2019) Archana Kushwaha; Juhi Srivastava; Ambareesh Kumar Singh; Richa Anand; Richa Raghuwanshi; Tulika Rai; Meenakshi Singh
Mycobacterium leprae causes endemic disease leprosy which becomes chronic if not treated timely. To expedite this ‘timely diagnosis’, and that also at an early stage, here an attempt is made to fabricate an epitope-imprinted sensor. A molecularly imprinted polymer nanoparticles modified electrochemical quartz crystal microbalance sensor was developed for sensing of Mycobacterium leprae bacteria through its epitope sequence. Multiple monomers, 3-sulphopropyl methacrylate potassium salt, benzyl methacrylate and 4-aminothiophenol were utilized to imprint this bacterial epitope. Imprinted nanoparticles were electropolymerized on gold coated quartz electrode. The sensor was able to show specific binding towards the blood samples of infected patients, even in the presence of ‘matrix’ and other plasma proteins such as albumin and globulin. Even other peptide sequences, similar to epitope sequences only with two amino acid mismatches were also unable to show any binding. Sensor withstood analytical tests viz. selectivity, specificity, matrix effect, detection limit (0.161 nM), quantification limit (and 0.536 nM), reproducibility (RSD 2.01%). Hence a diagnostic tool for bacterium causing leprosy is successfully fabricated in a facile manner which will broaden the clinical access and efficient population screening can be made feasible. © 2019 Elsevier B.V.
Familial syringomas
(2013) Satyendra Kumar Singh; Tulika Rai
[No abstract available]
High-Resolution Ultrasound in Evaluation of Peripheral Neuropathy in Patients of Hansen’s Disease
(Wolters Kluwer Medknow Publications, 2024) Tulika Rai; Atul M. Singh; Manish Indal; Ishan Kumar
Introduction: Hansen’s disease (HD) is a major public health problem in developing countries. It causes peripheral neuropathy, and if left untreated, it leads to deformities. It is important to diagnose such cases early, and prompt treatment should be given to patients to preserve nerve function. Materials and Methods: A total of 40 patients with HD who were already on multi‑drug therapy (MDT) or treatment‑naive were included in this study. These were clinically diagnosed cases of HD as per the Ridley–Jopling classification, and these patients were subjected to high‑resolution ultrasonography (HRUS). A total of 19 controls were also included. The patients were clinically evaluated, and HRUS of bilateral ulnar nerves (UNs) was performed in all cases and controls. The other peripheral nerves, if clinically thickened, were evaluated using HRUS. Results: The cross‑sectional area (CSA) of the UN in cases was significantly thickened as compared to controls. There was no difference in the CSA of patients on MDT as compared to treatment naïve patients. In two patients with pure neuritic HD, the clinical examination missed the bilateral nerve enlargement, and only unilateral nerve thickening was clinically appreciated. However, bilateral thickening was detected on HRUS. Conclusion: HRUS is a non‑invasive and sensitive diagnostic tool that gives significant information on nerve structure and morphology. HRUS adds a new dimension to diagnosing HD, particularly the pure neuritic type, with the assessment of early nerve damage, which can prevent disabilities. HRUS is an objective diagnostic tool that can complement the clinical examination. © 2024 Indian Dermatology Online Journal | Published by Wolters Kluwer - Medknow.
Hyperpigmented plaque with raised border at right angle of mouth involving oral mucosa
(2013) Manish Bansal; Tulika Rai
[No abstract available]
Lepromatous Ulcer
(Springer Nature, 2023) Tulika Rai
Leprosy also known as Hansen’s disease is a chronic, infectious disease caused by Mycobacterium leprae bacillus, which affects mainly peripheral nerves and skin but may also affect sites such as the eyes, mucous membranes, bones, and testes and produces a spectrum of clinical phenotypes [1, 2]. Although the prevalence of disease is decreasing, Hansen’s disease represents one of the major public health problems mainly in India and Brazil [3, 4]. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023.
Metastatic testicular cancer in a patient with arsenical keratosis
(Pakistan Association of Dermatologists, 2013) Satyendra Kumar Singh; Farzeen Nasir; Tulika Rai
Arsenicosis is a multisystem disorder, with many cutaneous features. The cutaneous manifestations take the form of pigmentary changes, hyperkeratosis, and skin cancers (Bowen's disease, squamous cell carcinoma, and basal cell carcinoma). It is a known carcinogen and there is association between chronic arsenic exposure and malignancy of bladder, lung, liver, kidney and other visceral malignancies. Our patient came from an endemic area where levels of arsenic are high in drinking water and had features of arsenical keratosis for past fifteen years along with metastatic testicular cancer at the time of presentation. Arsenic exposure may increase the risk of testicular cancer.
PhotoDermDiagnosis multiple umbilicated papulonodular lesions in an immunocompetent lady
(2013) Satyendra Kumar Singh; Tulika Rai; Taniya Sharma; Anand Prabhu
[No abstract available]
Posterior quadrantic dysplasia with localized hemimegalencephaly in a patient with giant congenital melanocytic nevus: First case report
(SAGE Publications Inc., 2019) Ishan Kumar; Priyanka Aggarwal; Tulika Rai; Vineeta Gupta
Giant congenital melanocytic nevus (GCMN) is associated with neurocutaneous melanocytosis and various other neurological complications. Its association with migrational anomalies of the brain is extremely rare. Herein, we document the first case of GCMN in a one-day-old baby associated with localized hemimegalencephaly (HME) of the brain with extensive malformation of cortical development including polymicrogyria, pachygyria and sublobar dysplasia, limited to an enlarged quadrant of the brain. HME and GCMN are considered embryological anomalies of cell migration and proliferation. We discuss the unusual magnetic resonance imaging findings along with a brief review of the literature. To the best of our knowledge, our case is the first to report the association of GCMN with localized HME. © The Author(s) 2019.
Pregabalin Induced Maculopapular Eruption in an Elderly Male
(Bentham Science Publishers, 2022) Sumit Jaiswal; Sankha Shubhra Chakrabarti; Tulika Rai; Neeraj Dhameja; Atul Mohan; Vandana Yadav; Upinder Kaur
Background: Pregabalin is used in the treatment of neuropathic pain of various etiolo-gies and as an adjuvant in epilepsy. Blockade of the α2δ subunit of L and N-type Ca-channels is its main mechanism of neurotropic action. Compared to other antiepileptics like phenytoin, valproate and lamotrigine, and other neuropathic pain medications such as amitriptyline and duloxetine, pregabalin has a relatively favorable safety profile and hence is a drug of choice for many geriatri-cians. Case Presentation: Here we describe a case of maculopapular rash induced by pregabalin in an older man, which resolved with withdrawal of the offending drug and conservative management. Conclusion: We have also conducted a literature review of similar cases and highlighted the clinical patterns and management strategies for pregabalin-induced skin rashes. © 2022 Bentham Science Publishers.