Browsing by Author "Vivek Dave"

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A Critique: Advancement and Applications of Surgical Sutures in Medical Implants
(CRC Press, 2024) Shovan Ghosh; Vivek Dave; Prashansa Sharma; Pranay Wal
Surgical sutures are thread-like structures that play a crucial role in injury management by holding tissue at the site of application. This became an important aspect in the promotion of any wound healing properties. In this chapter, we cover those areas along with their different classifications based on construction, degradation behavior, surface texture, size, coating, use, etc. The site of application, the risk factor, the mechanical requirement, and the depth of injury all influence the choice of suture, and choosing the right sutures always maximizes wound healing. The use of modified electrospinning in surgical sutures is important in the incorporation of bioactive molecules in sutures, which improves healing and can also deliver drugs. © 2024 selection and editorial matter, Prashansa Sharma, Devsuni Singh, Suman Pant and Vivek Dave; individual chapters, the contributors.
Advancement of Nanomedical Biotextiles for Infection Control and Protection Materials
(CRC Press, 2024) Shovan Ghosh; Vivek Dave; Prashansa Sharma; Pranay Wal
Personal protective equipment (PPE) is a health-related product used for individual protection and infection control, so those products must contain some standard quality. The application of biotextiles is effectively improving the protection quality and acceptance of PPE in terms like strength, protective efficiency, biosafety, rigidity, comfort, etc. The properties of different natural and synthetic polymers are incorporated, along with different nanomaterials, in the medical biotextile structure through fabrication technologies like melt extraction, electrospinning, wet spinning, etc., and coating. These processes contribute to the increased efficiency of textiles, which is why their use in the medical field is growing. We will look at a few key pieces of personal protective equipment (PPE) that have become an important part of our daily lives as a result of the recent pandemic, such as protective face masks and face shields for respiratory control, gloves for hand hygiene and health hazards protection, gowns for full body protection, and nanocare wipes as a health-hygienic product, in this chapter. Though polymer-based products play an important role in human safety, extreme use and improper disposal of those plastic-based products create environmental threats, so proper control is necessary. © 2024 selection and editorial matter, Prashansa Sharma, Devsuni Singh, Suman Pant and Vivek Dave; individual chapters, the contributors.
AI in Pharmacy, Herbal Medicine and Drug Delivery: A Sci-fi or a Reality
(Bentham Science Publishers, 2022) Srija Sur; Prashansa Sharma; Vivek Dave
Artificial Intelligence (AI) has been one of the most debated topics of present times as it is transforming nature in almost every aspect. The challenge is to decide whether it will make the planet a better place to live or it will push the human race towards disaster. The seed of AI was sown during the 1950s and continues to hold great future potential. Different policies had been laid down by the government for the ethical use of robots. The chapter gives a glimpse of AI policies in India. The chapter also enumerates the correlation between natural intelligence and software through various software languages like natural language processing, etc. It explains how this interaction between robots and natural intelligence has brought about widespread application. Robots can be used as scientists, nannies, pets, assist doctors in surgery, for cleaning, to provide security, to be used in pharmacies for automated dispensing systems, act as a virtual human body to predict how it will react to new therapeutic drugs, make drug development and drug delivery faster, etc. The policies regarding these robots are made so that they are not misused as their application is increasing day by day. This chapter also enumerates a lot about future aspects of artificial intelligence in traditional medicine. © 2022, Bentham Books imprint.
Compression Bandage and Wound Care Biomaterial With Nanotechnology
(CRC Press, 2024) Vaibhav Verma; Vivek Dave; Prashansa Sharma; Devsuni Singh
Nanotechnology-based bandages and wound care biomaterials have enormous potential for treating and preventing wound infections due to their numerous advantages over traditional treatment approaches. As wound healing remains a concern for the medical community, wound treatment becomes a crucial aspect of healthcare systems. One field that may offer novel approaches to regenerative medicine is nanotechnology and biomaterial technology. It is critical to understand the role of nanotechnology and biomaterial technology, which, when used to incorporate drugs into nano-and biomaterials, respectively, and then loaded in nanofibre-based bandages, compression bandages, stockings, or antimicrobial dressings, will provide unique wound management properties. Conventional burn treatments are available, but they are ineffective when compared to nano-and biomaterial-based compression bandages and stockings utilized in wound dressings. Furthermore, because of their underlying healing properties and wide range of antibacterial activity, novel antimicrobial agents, such as silver nanotechnology have gained a notable amount of interest in recent years. So, in this chapter, we went over the wound, its classification, and the stages of wound healing, as well as various medical textiles such as compression bandages and stockings-their classification, benefits, and applications. We also discuss briefly the nanomaterials and biomaterials employed in making bandages and dressings. © 2024 selection and editorial matter, Prashansa Sharma, Devsuni Singh, Suman Pant and Vivek Dave; individual chapters, the contributors.
Corrigendum to “One-pot hydrothermal green synthesis of Polygala tenuifolia mediated graphene quantum dots for acetylcholine esterase inhibitory activity” [J. Drug Deliv. Sci. Technol., 73(2022) 103486] (Journal of Drug Delivery Science and Technology (2022) 73, (S1773224722003963), (10.1016/j.jddst.2022.103486))
(Editions de Sante, 2024) Kajal Tak; Prashansa Sharma; Rekha Sharma; Vivek Dave; Smita Jain; Swapnil Sharma
The authors regret that the original published version of this article is has errors in Fig. 8 entitled Histopathological study of hippocampus tissue of rat and should be replaced with the corrected one provided below.[Formula presented] The authors would like to apologise for any inconvenience caused. © 2024
Description of the Processing Techniques Used in Biotextiles for Medical Application
(CRC Press, 2024) Prashansa Sharma; Devsuni Singh; Suman Pant; Vivek Dave
Biotextiles as structures composed of textile fibres have recently attracted a lot of interest for usage in a range of medical applications due to their affordability and distinctive physical and chemical characteristics. This chapter summarizes the biopolymers created from natural or synthetic materials that are utilized in the mitigation, medication, or diagnosis of disease or injury and various fibre production techniques to generate polymer monomers into textile filament including melt-, wet-, dry-, electrospinning, and multi/bicomponent spinning. Moreover, various fabrication techniques used to convert fibre into textile structures, in order to get achieve the required form, shape, and mechanical qualities for a medical device such as knitted, woven, nonwoven, braided, and nonwoven ePTFE techniques are explained. Finally, several drug-releasing techniques of bioactive compounds are used to create drug-loaded fibrous structures. © 2024 selection and editorial matter, Prashansa Sharma, Devsuni Singh, Suman Pant and Vivek Dave; individual chapters, the contributors.
Ecofriendly fabrication of cobalt nanoparticles using Azadirachta indica (neem) for effective inhibition of Candida-like fungal infection in medicated nano-coated textile
(Springer, 2024) Devsuni Singh; Prashansa Sharma; Suman Pant; Vivek Dave; Rekha Sharma; Rakesh Yadav; Anand Prakash; Arindam Kuila
This study involves the formulation of cobalt nanoparticles by means of ethanolic Azadirachta indica (neem) extract (CoNP@N). Later, the formulated buildup was incorporated into cotton fabric in order to mitigate antifungal infection. Optimization of the formulation was carried out by considering the effect of plant concentration, temperature, and revolutions per minute (rpm) used, through design of the experiment (DOE), response surface methodology (RSM), and ANOVA of the synthetic procedure. Hence, graph was potted with the aid of effecting parameters and the related factors (size of particle and zeta potential). Further characterization of nanoparticles was performed through scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Attenuated total reflection–Fourier transform infrared (ATR-FTIR) was considered for the detection of functional groups. The structural property of CoNP@N was calculated with the aid of powder X-ray diffraction (PXRD). The surface property was measured with the use of a surface area analyzer (SAA). The values of Inhibition concentration (IC50) and zone of inhibition (ZOI), were calculated, so as to determine the antifungal property against both the strains (Candida albicans, MTCC 227and Aspergillus niger, MTCC 8652). The further nano-coated cloth was subjected to a durability test, and hence the cloth was washed (through the purpose of time 0; 10; 25; and 50 washing cycles), and then its anti-fungal operation to a couple of strains was retained. Primarily, 51 μg/ml of cobalt nanoparticles incorporated on the cloth was retained but after 50 washing cycles in 500 ml of purified water, the cloth showed more efficiency contrary to C. albicans than towards A. niger. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023.
Green synthesized cobalt nanoparticles from Trianthema portulacastrum L. as a novel antimicrobials and antioxidants
(Taylor and Francis Ltd., 2024) Anand Prakash; Srija Sur; Vivek Dave; Prashansa Sharma; Suvadra Das; Partha Roy; Gurumurthy Hegde
Trianthema portulacastrum is a dietary and medicinal plant that has gained substantial importance due to its pharmacological properties. This plant was used for its various healing properties since the ancient period in ayurvedic system of medicine. The green synthesis technique is an eco-friendly as well as cost effective technique which can produce more biocompatible nanoparticles when compared with those fabricated by physio-chemical methods. Therefore, nanoparticles produced by green synthesis are credible alternatives to those which are produced by conventional synthesis techniques. This research mainly aims to produce nanoparticles with the methanolic leaf extract of T. portulacastrum. The optimized nanoparticles were further analyzed for anti-fungal, anti-bacterial and antioxidant properties. Disk diffusion assay was used for the determination of the antimicrobial property and on the other hand, DPPH radical scavenging assay as well as hydrogen peroxide scavenging activity proved the antioxidant property of the formulation. The study revealed that Escherichia coli (gram negative strain) shows greater zone of inhibition when compared with Bacillus subtilis (gram positive bacteria). The nanoparticles have also been reported to show significant anti-fungal activity against the strains of Aspergillus niger and Fusarium oxysporum which proves its desirability for its further use against both bacterial as well as fungal infections. The novel formulation can be explored dually as antimicrobial and antioxidant agent. © 2023 Taylor & Francis Group, LLC.
Improvised strategy of ethanolic nanovesicular gel of phospholipon 90G for transdermal delivery of luliconazole to mitigate fungal diseases
(Springer Science and Business Media Deutschland GmbH, 2023) Vivek Dave; Nikita Gupta; Anand Prakesh; Prashansa Sharma
The research work involves the development and characterization of ethanolic nanovesicular gel of different concentrations of the specified chemicals so as to estimate the optimized one among the rest. For the determination of its stability and suitability, optimized formulation was carried to a number of evaluation parameters such as particle size, zeta potential, polydispersity index (PDI), % entrapment efficiency (%EE), attenuated total internal reflection Fourier transforms infra-red spectroscopy (ATR-FTIR), transmission electron microscopy (TEM), atomic force microscopy (AFM), in vitro drug permeation study, stability studies, viscosity, pH, spreadability, extrudability, and last but not least, anti-fungal activity done by considering tube dilution assay. And finally, the results obtained were recorded and analyzed for all the parameters. The outcomes revealed that among nine nanovesicular formulations, ENV5 was found to be optimized, as because of its appropriate results for particle size, PDI, and zeta potential and highest % entrapment efficiency of about 169.5 nm, 0.407, −37.9 mV, and 80.07 ± 0.55% respectively, whereas in vitro drug permeation study expresses % cumulative release of 78.59 ± 0.43 in about 24 h. The suspension of nanovesicular system and lyophilized form of nanovesicular suspension both were examined and found to be very much stable at 4°C/60 ± 5 % RH than that of 25 °C/60 ± 5 % RH. Ultimately, the outcomes of the evaluation parameters have proved that the buildup is stable and suitable for topical application hence, leading to efficacious therapy of fungal diseases. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Modern Evolution in Drying, Dehydration, and Freeze-Drying of Food and Biomanufacturing
(wiley, 2024) Tarun Kumar; Holiga Vineeth; Prashansa Sharma; Vivek Dave
Freeze-drying is an ancient technique that converts the product from liquid form to amorphous form with the help of a sublimation process as well as restoring the content and food characteristics and some biotechnological products. Many foods and biotechnological products require a specific type of freeze-drying equipment to preserve the contents of the ingredients. In the conventional freeze-drying method, reliance on heat transfer can lead to a decrease in the end product’s quality and an elevated risk of impurities. However, recent advancements in freeze-drying technology have emerged, aiming to preserve the organoleptic properties and overall quality of food, vegetables, and certain medicinal product. © 2024 Scrivener Publishing LLC.
Nano-Biotechnology in Vascular Graft Implant and Heart Valve for Biotextile
(CRC Press, 2024) Amisha Singh; Prashansa Sharma; Vivek Dave
The term “biotextile” refers to a construction made of natural or synthetic fibers that is used in the medical industry. The development of nanotechnology and textile science has increased their acceptance and utilization in the medical profession. The use of biotextile in devices like heart valves and vascular grafts is covered in this chapter. Therefore, choosing a specific fiber became necessary for those purposes. For example, non-thrombogenic, anti-calcification material that is durable and long-lasting is preferred for heart valves, and fiber material for vascular grafts should have biocompatibility, hemocompatibility, biostability, etc. The effectiveness of those devices may be increased by using nanobiotechnology to incorporate different necessary inclusions of same properties in implemented devices by nanocoating, surface modification, nanoencapsulation, etc. © 2024 selection and editorial matter, Prashansa Sharma, Devsuni Singh, Suman Pant and Vivek Dave; individual chapters, the contributors.
Nano-Enhanced Biotextile Sterilization Techniques for Medical Applications
(CRC Press, 2024) Pallerla Naveen Reddy; Vivek Dave; Prashansa Sharma
Sterilization for nano-enhanced biotextiles which are used for medical applications has various challenges which require proper, especially those which are meant for internal use or implantation. Nano-enhanced biotextiles which are used for various medical applications are sterilized by various methods. So, in this chapter briefly mentioned are various traditional sterilization techniques, such as chemical sterilization and saturation/steam sterilization, these techniques are also known as conventional sterilization techniques; and non-traditional sterilization techniques such as plasma sterilization method, microwave sterilization method, and various other sterilization methods, these methods are also known as modern sterilization techniques. Various medical applications of these biotextiles show many future aspects in the fields of medicine, microfiltration components, dialysis filter system, implants, tissue engineering, bandages, anti-microbial fabrics, and many other uses. © 2024 selection and editorial matter, Prashansa Sharma, Devsuni Singh, Suman Pant and Vivek Dave; individual chapters, the contributors.
Nanotechnology and Biomaterials for Hygiene and Healthcare Textiles
(CRC Press, 2024) Shilpi Shree Sahay; Prashansa Sharma; Vivek Dave
Over recent years, nanotechnology has gained considerable attention as a highly engaging area of research. This chapter presents a comprehensive overview of nano-assisted medical textiles for hygiene and healthcare purposes, which helps in controlling the spread of infection, healing wounds, and curing diseases. Nanotechnology has provided enormous strength in designing and engineering products by incorporating the functional capability to accomplish a specific task. Within this context, the primary aim is to explore the ways by which nanomaterials and nanotechnology are utilized. At the same time, it seeks to provide an understanding of the inherently vast scope of medical textile applications in maintaining hygiene and developing healthcare products. In the era of innovations, nanotechnology has revolutionized the range of applications. It is capable of inducing healing capacity, repairing tissue damage, and treating organ failure and deformity restoration properties with advanced medical textile materials and products. Research efforts are primarily directed toward uncovering novel materials through molecular manipulation and at the atomic level. This exceptionally brilliant tool allows the development of the material’s intrinsic characteristics, which depend on the atomic structure. Additionally, the concept of sophisticated nanotechnology has offered multiple controllable, high-performance, and specialized features useful in meeting healthcare and hygiene-associated objectives. Several past studies have evaluated the rapidly advancing nanomaterials along with their inherent properties. The distinctive attributes of nanoworld reveal remarkable prospects across a wide array of usage striking opportunities in a diverse range of applications including drug delivery, tissue engineering, organ transplant, skin grafting, bone replacement, biomedical scaffolding, wound dressing, protective textiles, medical implants, biosensors, and so on. The outstanding biocompatible, porous, and non-toxic properties have led to the exploration and commercial utilization of various products in biomedical and healthcare fields. © 2024 selection and editorial matter, Prashansa Sharma, Devsuni Singh, Suman Pant and Vivek Dave; individual chapters, the contributors.
Nanotechnology Based Advanced Medical Textiles and Biotextiles for Healthcare
(CRC Press, 2024) Prashansa Sharma; Devsuni Singh; Suman Pant; Vivek Dave
This book provides systematic coverage of research into medical and biotextiles based on nanomaterials as applicable in healthcare. Divided into three sections, it explains manufacturing, properties, types, and recent developments in nanotechnology based medical textiles backed by case studies. It includes a wide range of different clinical applications of biotextiles for healthcare including nanotextile scaffolds, nano-based artificial organs, surgical sutures, enzymatic assisted enhanced biotextiles, tissue engineering or drug delivery system via nanofibers, and so forth. Features: Provides strong and broad overview of medical applications in the field of nano and biotextiles. Highlights different approaches, recent research, and emerging innovations. Covers designing or developing nanomaterials based antiviral surface disinfectants with self-cleaning property. Reviews different applications of nano based medical textiles such as deodorizing or pH control clothing for hygiene maintenance. Includes the real-life applications based descriptive case studies that offer a diverse range of perspectives. This book is aimed at researchers and graduate students in textile technology and engineering, and medical textiles. © 2024 selection and editorial matter, Prashansa Sharma, Devsuni Singh, Suman Pant and Vivek Dave; individual chapters, the contributors.
One-pot hydrothermal green synthesis of Polygala tenuifolia mediated graphene quantum dots for acetylcholine esterase inhibitory activity
(Editions de Sante, 2022) Kajal Tak; Prashansa Sharma; Rekha Sharma; Vivek Dave; Smita Jain; Swapnil Sharma
The present paper reports the synthesis of Donepezil hydrochloride functionalized Graphene quantum dots (DO-ptGQD) for the cure of Alzheimer disease. Graphene quantum dots were synthesized through root extract of Polygala tenuifolia by using one-pot hydrothermal synthesis method. Using UV/Visible spectroscopy, FTIR, SEM, TEM and XPS methods, the synthesized ptGQD was evaluated. Further the formulated DO-ptGQD was evaluated by SEM, TEM, FTIR, XPS techniques and was further evaluated for the encapsulation study, in-vitro study and various in-vivo models. Through behavioural model (Radial arm maze and Water morris maze assay) the learning and memory ability of the formulations was evaluated and the outcomes indicate that the DO-ptGQD markedly decreases the transmission latency to get in the baited arm in 12.19 ± 0.39 s or to the hidden stage in 15.37 ± 0.45 in 7 days. DO-ptGQD show more percentage inhibition of AchE enzyme that is 86.23 ± 1.28 as likened with the drug and ptGQD. DO-ptGQD considerably increases the protein and glutathione level and decreases the nitric oxide and lipid peroxide level. The Histopathological image indicates that DO-ptGQD treats the disorganization of the cell and show more preservation of small pyramidal cells as compared with the other formulations. In conclusion, DO-ptGQD was safe and effective drug delivery system for the treatment of Alzheimer disease and also the root extract of Polygala tenuifolia provide synergistic effect for the treatment of disease. © 2022
Preface
(CRC Press, 2024) Prashansa Sharma; Devsuni Singh; Suman Pant; Vivek Dave
[No abstract available]
Prevailing Eco-Parameters and Protocols for Nanotechnology in the Textile Industry
(wiley, 2025) Sanduru Sai Keerthana; Vivek Dave; Prashansa Sharma
Nanotechnology is widely regarded as a tool for resolving issues and improving the standard of living. With rising customer demand for functional clothing that is produced sustainably, nanomaterials can now be incorporated into textile substrates. Consumption and trash production have increased as a result of the quick fashion cycle in the textile sector. The industry aspires to create safe and environmentally friendly textiles while utilizing the advantages of emerging nanomaterials. To ensure the continued development of nanomaterials in the future, it is imperative to be aware of both their potential benefits and unanticipated risks to the environment and human health. Among all the sectors, apparel industry is one of the most polluting sectors; this could have a severe effect on the environment. The appropriate regulations will allow for the mitigation of problems related to the production of nanotextiles and will support the responsible and safe advancement of nanotechnology. In this chapter, we will discuss about recycling, eco-friendly parameters, protocols, and applications related to nanotechnology. © 2025 Scrivener Publishing LLC.
Protective face mask: an effective weapon against SARS-CoV-2 with controlled environmental pollution
(Springer, 2024) Shovan Ghosh; Vivek Dave; Prashansa Sharma; Akash Patel; Arindam Kuila
Masks are face coverings that give protection from infectious agents, airborne pathogens, bacteria, viruses, surgical fog, dust, and other chemical hazards by acting as a barrier between the wearer and the environment. In the COVID-19 pandemic, this major personal protective equipment’s became essential part of our daily life. The aim of this review is to analyze and discuss the different types of masks with their pros and cons, manufacturing procedures, evaluation criteria, and application with some of the sterilization process for reuse and smart mask. The review used a thorough examination of the literature to analyze the preventive effects of surgical, N95, smart mask, and potential environmental damage from those masks. Several studies and evidence were also examined to understand the efficiency of different mask on different environment. N95 respirators are capable of filtering out non-oil-based 95% air-born particles, and surgical masks act as a protective barrier between the wearer and the environment. The application of spoon bond and melt blown techniques in the fabrication process of those masks improves their protective nature and makes them lightweight and comfortable. But the high demand and low supply forced users to reuse and extend their use after sterilizations, even though those masks are recommended to be used once. Universal masking in the SARS-COV-2 pandemic increased the chance of environmental pollution, so the application of smart masks became essential because of their high protection power and self-sterilizing and reusing capabilities. Graphical abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023.
Revolutionizing environmental sustainability: exploring the transformative potential of nanocomposites/nanomaterials from recycled waste
(Springer, 2024) Vivek Dave; Prashansa Sharma; Arindam Kuila; Shilpi Shree Sahay
[No abstract available]