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Role of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) genes in neuro-HIV
(Elsevier, 2024) HariOm Singh; A. Antony Jenitha; Ranjana Choudhari; Amita Verma; Anchal Singh
Neuro-HIV is a chronic disease due to neuro-inflammation, which is triggered by HIV's entry into the CNS and is initiated rapidly post-infection. CNS inflammation and the associated neurological diseases in HIV-infected individuals are the most difficult problems to solve post-HAART. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are responsible for widespread destruction because they are potent proteolytic enzymes. MMPs are inhibited by endogenous TIMPs. TIMPs and MMPs are involved in several diseases, including HIV-associated neurological diseases (HAND). Tat viral protein that controls HIV transcription and its expression has a duration that is independent of HIV-associated neuro-inflammation and influences MMP and TIMP gene expression. MMPs are diverse and polymorphic in nature. The book chapter provides comprehensive reports on the genetic polymorphisms of MMPs and TIMPs, their association with pathological conditions of neuro-HIV, and role of the Tat protein in association with HIV-1 in neuro-HIV. © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.