2024

Permanent URI for this collectionhttps://dl.bhu.ac.in/bhuir/handle/123456789/36736

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Now showing 1 - 9 of 9

A comparative analysis of phytochemicals versus synthetic drugs/nanomedicines in the treatment of uterine fibroid: a systematic review
(Korean Society of Environmental Risk Assessment and Health Science, 2024) Sonal Upadhyay; Vivek Pandey; Anima Tripathi; Alakh N. Sahu; Anjali Rani; Amita Diwakar; Lavina Chaubey; Rashmi Gupta; Pawan K. Dubey
Most women experience uterine fibroids (UFs), a common benign gynecological tumor, at some point in their reproductive age. There are several pharmacological treatments available to shrink fibroids and lessen the UF symptoms. These medications cost a lot of money, though, and frequently have serious side effects. Therefore, due to their low cost, comparable and powerful therapeutic efficiency and lower side effects, phytochemical-based medications are gaining popularity in these days. This review's goal is to provide a summary of the knowledge that is currently unavailable regarding the mechanisms of the action of various phytochemical-based medications with anti-uterine fibroid efficacy. The present results showed that dietary phytocompounds (dehydroxyelephantopin, butein, capsaicin, fisetin, kaempferol, resveratrol, silibinin and curcumin) could probably be effective as therapeutic compounds for uterine leiomyoma. These phytochemicals indicated their capability to regulate main fibroid promoting and initiating events for instance, proliferation, inflammation, angiogenesis and fibrosis in various experimental setups through modulating various signaling pathways, such as Smad 2/3, PI3K/AKT/mTOR, ERK 1/2 and β-catenin indicating that they could serve as targets for prevention and/or treatment of UFs. This review provides key molecular insights for the development of phytochemical-based novel personalized therapy for non-surgical management of UFs which may help to avoid hysterectomy. © The Author(s), under exclusive licence to Korean Society of Environmental Risk Assessment and Health Science 2023.
An in-depth and insightful exploration of failure detection in distributed systems
(Elsevier B.V., 2024) Bhavana Chaurasia; Anshul Verma; Pradeepika Verma
In today's world, everyone wants a good profit with a tiny investment and distributed computing is a boon for this purpose. Cloud computing, fog computing, and the Internet of Things (IoT) are well-known examples of distributed computing which provide good computing services and performance. However, providing reliable services in a real environment, which is failure-prone, remains a challenge. To address this issue, failure detectors are used in distributed systems, which are abstract modules responsible for detecting and monitoring the activity of nodes in order to determine whether they are faulty or not. In this paper, an approach is presented for the systematic literature review of failure detectors in distributed systems. Further, many existing review and survey papers on failure detectors are critically analyzed along with their key contributions and limitations. The classification of distributed systems is presented on the basis of the nodes’ properties and the components of system models are described in detail. Various issues and challenges related to agreement and failure problems are also explored. The strengths and limitations of various existing failure detectors are discussed along with their comparative evaluation. Finally, fault-tolerance and recovery techniques are discussed and analyzed. © 2024 Elsevier B.V.
Cleavage of cell junction proteins as a host invasion strategy in leptospirosis
(Springer Science and Business Media Deutschland GmbH, 2024) Preeti Kumari; Suhani Yadav; Sresha Sarkar; Padikara K. Satheeshkumar
Abstract: Infection and invasion are the prerequisites for developing the disease symptoms in a host. While the probable mechanism of host invasion and pathogenesis is known in many pathogens, very little information is available on Leptospira invasion/pathogenesis. For causing systemic infection Leptospira must transmigrate across epithelial barriers, which is the most critical and challenging step. Extracellular and membrane-bound proteases play a crucial role in the invasion process. An extensive search for the proteins experimentally proven to be involved in the invasion process through cell junction cleavage in other pathogens has resulted in identifying 26 proteins. The similarity searches on the Leptospira genome for counterparts of these 26 pathogenesis-related proteins identified at least 12 probable coding sequences. The proteins were either extracellular or membrane-bound with a proteolytic domain to cleave the cell junction proteins. This review will emphasize our current understanding of the pathogenic aspects of host cell junction-pathogenic protein interactions involved in the invasion process. Further, potential candidate proteins with cell junction cleavage properties that may be exploited in the diagnostic/therapeutic aspects of leptospirosis will also be discussed. Key points: • The review focussed on the cell junction cleavage proteins in bacterial pathogenesis • Cell junction disruptors from Leptospira genome are identified using bioinformatics • The review provides insights into the therapeutic/diagnostic interventions possible © 2024, The Author(s).
Engineering regulatory networks of cyanobacteria
(Elsevier Ltd, 2024) Riya Bongirwar; Pratyoosh Shukla
Engineering a cell's regulatory networks to dynamically control gene expression has been considered a new frontier in biological engineering. In cyanobacteria, the lack of well-characterized, modular gene regulatory elements makes regulatory network engineering challenging. Here, we suggest potential tools to modify various gene expression steps in cyanobacterial regulatory networks. © 2024 Elsevier Ltd
Navigating competency-based medical education in ophthalmology: Addressing challenges and charting future trajectories
(IP Innovative Publication Pvt. Ltd., 2024) Rahul Singh; Disha Chaudhary; Brijesh Kr Kushwaha; Rajendra P. Maurya
Based Medical Education (CBME) has emerged as a transformative approach to medical training, emphasizing skills acquisition and holistic competence over traditional knowledge retention. Ophthalmology, as a specialized field, presents unique challenges and opportunities within this framework. This article critically examines the implementation of CBME in ophthalmology, highlighting challenges faced and proposing strategies for enhancement. By addressing stakeholder perspectives and strategic interventions, this viewpoint aims to foster a comprehensive understanding of CBME’s implications for ophthalmological education. © 2024 Author(s), Published by Innovative Publication.
Palm-based beverages around the world: A review
(Bentham Science Publishers, 2024) V.P. Aparnna; Anil Kumar Chauhan; Shubhendra Singh
Palms have been a source of food, drinks, oil, lumber, sugar, and the sap it produces. Palm sap is a refreshing, non-alcoholic beverage that has a plethora of health benefits. Some examples of palm-based beverages are Neera, toddy, tuba, wine, arak, and other traditional fermented drinks, along with concentrated syrups. Palm sap-based beverages are high in carbohydrates, vital amino acids, and vitamins and are consumed as energy drinks around the world. Antioxidants, which have been shown to have a good effect on human health, are also found naturally in palm-based beverages. Technological advancement, marketing, and a lack of research and training hinder the commercialization of nutritional by-products made from palm sap. The current review aims to focus on palm-based beverages, their health benefits, recent developments, and future perspectives. © 2024 Bentham Science Publishers.
Protein Engineering in Cyanobacterial Biotechnology: Tools and Recent Updates
(Bentham Science Publishers, 2024) Swati Tyagi; Srabani Kar; Amit Srivastava; Pratyoosh Shukla
Cyanobacteria have emerged as a microbial cell factory to produce a variety of bioprod-ucts, including peptides and proteins. Cyanobacteria stand out among other organisms due to their photoautotrophic metabolism and ability to produce a wide range of metabolites. As photoau-totrophic hosts can produce industrial compounds and proteins by using minimal resources such as sunlight, atmospheric carbon dioxide, and fewer nutrients, cyanobacteria are cost-effective industrial hosts. Therefore, the use of protein engineering tools for rational protein design, and the de-sired modification of enzyme activity has become a desirable undertaking in cyanobacterial biolo-gy. Protein engineering can improve their biological functions as well as the stability of their intracellular proteins. This review aims to highlight the success of protein engineering in the direction of cyanobacterial biotechnology and outlines the emerging technologies, current challenges, and prospects of protein engineering in cyanobacterial biotechnology. © 2024 Bentham Science Publishers.
Status of visfatin in female reproductive function under normal and pathological conditions: a mini review
(Springer Science and Business Media B.V., 2024) Lalrawngbawli Annie; Pranay Punj Pankaj; Rajesh Kumar Kharwar; Ajit Singh; Vikas Kumar Roy
Adipokines are now well-known to regulate reproduction. Visfatin is an adipokine expressed in the hypothalamus, pituitary, ovary, uterus, and placenta of different species, and since it has been found to modulate the endocrine secretion of the hypothalamus, pituitary gland and ovary, it may be considered a novel regulator of female reproduction. Although the majority of the literature explored its role in ovarian regulation, visfatin has also been shown to regulate uterine remodeling, endometrial receptivity and embryo development, and its expression in the uterus is steroid dependent. Like other adipokines, visfatin expression and levels are deregulated in pathological conditions including polycystic ovary syndrome. Thus, the present mini-review focuses on the role of visfatin in female reproduction under both physiological and pathological conditions. © The Author(s), under exclusive licence to Springer Nature B.V. 2024.
Wafer scale growth of single crystal two-dimensional van der Waals materials
(Royal Society of Chemistry, 2024) Chetna Gautam; Baishali Thakurta; Monalisa Pal; Anup Kumar Ghosh; Anupam Giri
Two-dimensional (2D) van der Waals (vdW) materials, including graphene, hexagonal boron nitride (hBN), and metal dichalcogenides (MCs), form the basis of modern electronics and optoelectronics due to their unique electronic structure, chemical activity, and mechanical strength. Despite many proof-of-concept demonstrations so far, to fully realize their large-scale practical applications, especially in devices, wafer-scale single crystal atomically thin highly uniform films are indispensable. In this minireview, we present an overview on the strategies and highlight recent significant advances toward the synthesis of wafer-scale single crystal graphene, hBN, and MC 2D thin films. Currently, there are five distinct routes to synthesize wafer-scale single crystal 2D vdW thin films: (i) nucleation-controlled growth by suppressing the nucleation density, (ii) unidirectional alignment of multiple epitaxial nuclei and their seamless coalescence, (iii) self-collimation of randomly oriented grains on a molten metal, (iv) surface diffusion and epitaxial self-planarization and (v) seed-mediated 2D vertical epitaxy. Finally, the challenges that need to be addressed in future studies have also been described. © 2024 The Royal Society of Chemistry.