2024
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PublicationReview Recent progress in gas sensing based on 2D SnS2 and its heterostructure platforms: A review(Elsevier B.V., 2024) Rajneesh Kumar Mishra; Hyeon Jong Choi; Jeong Won Ryu; Gyu Jin Choi; Vipin Kumar; Pushpendra Kumar; Jay Singh; Santosh Kumar; Jin Seog GwagThe surface and electronic engineering of the 2D SnS2 have recently attracted substantial courtesies in various applications due to the abundant active oxygen sites and high transport properties because of electronic modulation. Herein, we reviewed the recent signs of progress in the morphological, structural, elemental properties, and gas-detection characteristics of the two-dimensional SnS2. Furthermore, it also offers information on recent advancements and developments of various types of gas sensors prepared using the SnS2 and its heterostructures. Numerous influential gas recognition parameters have also been discussed. The gas sensing mechanisms are also discussed on NH3, NO2, H2S, and VOCs to explore the interactions of the test gas with the sensor surface, elucidating the crucial role of active surface and electronic features of SnS2 and its heterostructures on the rapid response and recovery profiles. Besides, it provides insight into the adsorption/desorption chemistry on the sensor's surface and eco-friendly environment. However, it is found that there is still vast scope for SnS2 sensors to detect several other gases, which are still not studied and reported in the literature. Therefore, it opens up a new opportunity to develop various types of gas sensors to discriminate the particular gas at optimum working temperature and concentrations. Finally, the review clinches with the future perspectives and positions of the SnS2-based gas sensors. © 2023 Elsevier B.V.PublicationArticle Regulation of neuroinflammation in Alzheimer's disease via nanoparticle-loaded phytocompounds with anti-inflammatory and autophagy-inducing properties(Elsevier GmbH, 2024) Vinayak Nayak; Sushmita Patra; Shrushti Rout; Atala Bihari Jena; Rohit Sharma; Kali Prasad Pattanaik; Jay Singh; Shyam S. Pandey; Ravindra Pratap Singh; Sanatan Majhi; Kshitij RB Singh; Rout George KerryBackground: Alzheimer's disease (AD) is characterized by neuroinflammation linked to amyloid β (Aβ) aggregation and phosphorylated tau (τ) protein in neurofibrillary tangles (NFTs). Key elements in Aβ production and NFT assembly, like γ-secretase and p38 mitogen-activated protein kinase (p38MAPK), contribute to neuroinflammation. In addition, impaired proteosomal and autophagic pathways increase Aβ and τ aggregation, leading to neuronal damage. Conventional neuroinflammation drugs have limitations due to unidirectional therapeutic approaches and challenges in crossing the Blood-Brain Barrier (BBB). Clinical trials for non-steroidal anti-inflammatory drugs (NSAIDs) and other therapeutics remain uncertain. Novel strategies addressing the complex pathogenesis and BBB translocation are needed to effectively tackle AD-related neuroinflammation. Purpose: The current scenario demands for a much-sophisticated theranostic measures which could be achieved via customized engineering and designing of novel nanotherapeutics. As, these therapeutics functions as a double edge sword, having the efficiency of unambiguous targeting, multiple drug delivery and ability to cross BBB proficiently. Methods: Inclusion criteria involve selecting recent, English-language studies from the past decade (2013–2023) that explore the regulation of neuroinflammation in neuroinflammation, Alzheimer's disease, amyloid β, tau protein, nanoparticles, autophagy, and phytocompounds. Various study types, including clinical trials, experiments, and reviews, were considered. Exclusion criteria comprised non-relevant publication types, studies unrelated to Alzheimer's disease or phytocompounds, those with methodological flaws, duplicates, and studies with inaccessible data. Results: In this study, polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor (anti-TfR) present on BBB. Thereafter, the engineered nanoparticles with the ability to efficiently traverse the BBB and interact with target molecules within the brain, could induce autophagy, a cellular process crucial for neuronal health, and exhibit potent anti-inflammatory effects. Henceforth, the proposed combination of desired phytocompounds, polymeric nanoparticles, and anti-TfR coating presents a promising approach for targeted drug delivery to the brain, with potential implications in neuroinflammatory conditions such as Alzheimer's disease. © 2023 Elsevier GmbHPublicationArticle Development of a biodegradable microfluidic paper-based device for blood-plasma separation integrated with non-enzymatic electrochemical detection of ascorbic acid(Elsevier B.V., 2024) Neha Gautam; Rahul Verma; Rishi Ram; Jay Singh; Arnab SarkarIn the present article, we developed an electrochemical microfluidic paper-based device (EμPAD) for the non-enzymatic detection of Ascorbic Acid (AA) concentration in plasma using whole human blood. We combined LF1 blood plasma separation membrane and Whatman grade 1 filter paper to separate plasma from whole blood through wax printing. A screen-printed electrode (SPE) was modified with spherical-shaped MgFe2O4 nanomaterial (n-MgF) to improve the catalytic properties of SPE. The n-MgF was prepared via hydrothermal method, and its material phase and morphology were confirmed via XRD, FTIR, TEM, SEM, and AFM analysis. The fabricated n-MgF/SPE/EμPAD exhibited detection of AA ranging from 0 to 80 μM. The obtained value of the detection limit, limit of quantification, sensitivity, and response time are 2.44 μM, 8.135 μM, 5.71 × 10−3 mA μM−1 cm−2, and 10 s, respectively. Our developed n-MgF/SPE/EμPAD shows marginal interference with the common analytes present in plasma, such as uric acid, glutamic acid, glucose, urea, lactic acid, and their mixtures. Overall, our low-cost, portable device with its user-friendly design and efficient plasma separation capability offers a practical and effective solution for estimating AA concentration from whole human blood in a single step. © 2023 Elsevier B.V.PublicationEditorial Preface(Elsevier, 2024) Pratima R. Solanki; P.V. Mohanan; Ravindra Pratap Singh; Jay Singh; Ajit Khosla; Kshitij RB Singh[No abstract available]PublicationBook Chapter Introduction: an overview of nanocoatings toward medical device(Elsevier, 2024) Arunadevi Natarajan; Kshitij RB Singh; Pratima R. Solanki; Jay Singh; Ravindra Pratap SinghNanomaterial’s research has many interesting and proven results in the progression of the biomedical and pharmaceutical fields. The process of interlinking nanoparticles/composites with medical devices in the form of coatings and target delivery systems paved new horizons for the diagnosis and treatment of many diseases. The outstanding characteristics and functional properties of nanomaterials upsurge the efficacy, decrease the difficulties connected with medical devices, and advance the accuracy and function of drug delivery systems. Hence, in this chapter, we presented the role of nanomaterial in medical devices with the help of nanotechnology, their merits, and mitigating the disadvantages of improper handling of these nanocompounds. © 2024 Elsevier Ltd. All rights reserved.PublicationBook Next-Generation Antimicrobial Nanocoatings for Medical Devices and Implants(Elsevier, 2024) Pratima R. Solanki; P.V. Mohanan; Ravindra Pratap Singh; Jay Singh; Ajit Khosla; Kshitij RB SinghNext-Generation Antimicrobial Nanocoatings for Medical Devices and Implants provides a detailed, up-to-date overview of the nano-based antimicrobial coatings used to combat medical device-related biofilms. An introduction to biofilms and how they infect medical devices is included, as well as strategies/modification techniques used to target these biofilms. This book evaluates the various antimicrobial coatings formed using nanomaterials such as silver, inorganic materials, organic materials, carbon dots, surfactants, and electrospun fibers, specifically for us on medical devices and implants. Numerous coating methods are discussed, along with the biological characterizations of these coating materials, and their toxicological and environmental impact. This book is a useful reference for materials scientists, biomedical engineers, and those working on the development of novel biomaterials for use in medical devices and implants. © 2024 Elsevier Ltd. All rights reserved.PublicationArticle Synthesis, In-Silico Molecular Docking Studies, and In-Vitro Antimicrobial Evaluation of Isatin Scaffolds bearing 1, 2, 3-Triazoles using Click Chemistry(Springer, 2024) Ritesh Anand; Nisha Yadav; Deeksha Mudgal; Simran Jindal; Sunak Sengupta; Deepak Kumar; Jay Singh; Nagendra Kumar Panday; Vivek MishraBacterial infections continue to present a formidable challenge to human health, prompting intensified research efforts towards the development of effective antibacterial agents. This study harnesses click chemistry techniques to synthesize Isatin-1,2,3-triazole as a novel antibacterial agent, evaluating its in vitro efficacy against prevalent pathogens including Gram-negative (Escherichiacoli) and Gram-positive (Staphylococcusaureus) strains using both the microdilution and well-diffusion methods. The findings reveal a notable enhancement in antibacterial activity upon incorporation of the triazole moiety into the Isatin framework against both E. coli and S. aureus. Further analysis, including structure–activity relationship studies and molecular docking investigations, highlights the superior antibacterial potency of triazole-tethered Isatin tosyl azide compared to N-propargyl Isatin. Molecular docking simulations with Staphylococcusaureus (PDB ID: 4TU5) and Escherichiacoli (PDB ID: 6YD9) proteins exhibit promising binding affinities of − 10.44 kJ/mol and − 8.4 kJ/mol, respectively. Isatin triazole demonstrates favorable gastrointestinal absorption properties, low toxicity profiles, adherence to Lipinski's rule of five, and compliance with Veber and Ghose standards. Furthermore, molecular dynamics simulations attest to the stability of protein complexes over a 100 ns timeframe. Collectively, these findings underscore the therapeutic potential of Isatin triazole compounds against bacterial infections, warranting further clinical exploration to elucidate their mechanisms of action and therapeutic efficacy. Graphical Abstract: (Figure presented.) © Association of Microbiologists of India 2024.PublicationArticle A Comprehensive Review on Plant-Based Medications and Chemical Approaches for Autism Spectrum Disorders (ASDs) Psychopharmacotherapy(Springer, 2024) Vrish Dhwaj Ashwlayan; Ratneshwar Kumar Ratnesh; Divya Sharma; Alok Sharma; Akansha Sangal; Alimuddin Saifi; Jay SinghGastrointestinal impairment induced sleep, behavioral and psychiatric disorders were reported in patients of autism spectrum disorders (ASDs). These may be life-long neuro-developmental disorders. Standardized diagnostic criteria for ASDs include: restricted and repetitive behavior, ongoing deficiencies in social interaction and communication. Pro-antioxidant and anti-inflammatory effects of dietry polyphenols/poly-phenol-rich derivatives as bioactive compounds enhanced permeability of blood brain barrier, consequently leads to delay in the onset of ASDs symptoms and can be effectively used in the management of ASDs. During the research on ASDs numerous therapeutic modalities, such as chemical and plant-based therapies, have been investigated. Due to their possible neuro-psychopharmacological benefits, plant-based treatments have attracted interest. These natural source therapies have demonstrated potential in reducing ASDs-related symptoms. Plant-based psycho-pharmaceuticals have been thoroughly investigated, and the investigations have confirmed their therapeutic effects. The therapeutic qualities of plants not only address the complex neurological aspects of ASDs but also provide a comprehensive approach to treatment. These substances may restore neurochemical equilibrium by focusing on particular biochemical pathways associated with the illness. Advancements in pharmacology and neurochemistry have enabled targeted interventions through chemical approaches. The treatment of ASDs approached through a combination of plant-based solutions and chemical methods can be better than one alone. By targeting the restorative properties of both natural compounds and synthesized chemicals, researchers aim to address the diverse range of symptoms and underlying neurobiological abnormalities associated with ASDs. Further clinical studies are required to validate the potential of bioactive molecules scientifically. Graphical Abstract: (Figure presented.). © Association of Microbiologists of India 2024.PublicationBook Chapter Physicochemical and Biological Properties of MXenes(wiley, 2024) Neakanshika Chadha; Aman Sahu; Kshitij R.B. Singh; Jay SinghTwo-dimensional (2D) materials due to their extraordinary properties have become very popular for technological applications. Amongst, MXene, of 2D material family shows some promising physiochemical properties that have potentials for utilization in numerous applications. Owing to their intriguing mechanical, biological, electronic properties, together with easy surface functionalization, and tunability of chemical structure, it has multidisciplinary utility. This chapter compiles the structural, physicochemical, and biological properties as well as unconventional progress on the various MXenes synthesized till date. Additionally, this work foregrounds the relevance of surface functionalities, chemical structure, morphology on the physicochemical properties, and multi-functionality of 2D MXenes. The chapter is concluded with an imperative outlook along with highlighting the limitation and challenges for future investigation of MXene-based materials. © 2024 John Wiley & Sons Ltd.PublicationBook MXenes: Next-Generation 2D Materials: Fundamentals and Applications(wiley, 2024) Jay Singh; Kshitij R.B. Singh; Ravindra Pratap Singh; Charles Oluwaseun AdetunjiMXenes: One-stop reference explaining the manufacturing, design, and many applications of MXenes in an easy-to-understand linear format MXenes is a one-stop reference on MXenes, a promising new class of 2D materials, discussing the routes of functionalization and modifications towards high performance materials and providing broad coverage of lab synthesis methods. To aid in reader comprehension, this text presents the topic in a linear fashion, starting with an introduction to MXenes and ending with a comparison of MXenes to other similar 2D materials, discussing limitations, advantages, future perspectives, and challenges of both MXenes and MXene-based materials. The text covers up-to-date research in the field with a strong focus on novel findings in various devices along with core technological advancements that have been made in recent years. MXenes discusses sample topics such as: • Properties of MXenes, including strong hydrophilicity, exceptional conductivity, high elastic mechanical strength, large surface-to-volume ratio, and chemical stability • Applications of MXenes in energy storage, optoelectronics, spintronics, biomedicine, electro-catalysis, photocatalysis, membrane separation, supercapacitors, and batteries • Performance factors that can hinder the efficacy of MXenes, including aggregation, difficulty obtaining a single layer, restacking, and oxidation of MXene nanosheets • State-of-the-art progress in the field of gas sensors and electrochemical biosensors for the detection of various biomolecules, pharmaceutical drugs, and environmental pollutants Containing everything readers need to know about this exciting new class of 2D materials, MXenes is an essential reference for professionals working in advanced materials science, flexible electronics, nanoelectronics, and the energy industry, along with chemists, material scientists, and engineers in nanoscience and nanotechnology. © 2024 John Wiley & Sons Ltd.