2009
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PublicationArticle Complications associated with neonatal resuscitation(Elsevier Ireland Ltd, 2009) Sriparna Basu; Ashok Kumar; Aditya Kumar Gupta[No abstract available]PublicationArticle Congenital rubella syndrome presenting at birth with blueberry muffin rash and communicating hydrocephalus(IOS Press, 2009) Sriparna Basu; Aditya Kumar Gupta; Ayan Kumar; Poonam Singh; Ashok KumarWe report a preterm, small-for-gestational age, very low birth weight male neonate presenting at birth with generalized reddish blue papulonodular lesions (including palms and soles), anemia, thrombocytopenia, hepatosplenomegaly, interstitial pneumonitis, sensorineural deafness, atrial septal defect, and communicating hydrocephalus. A diagnosis of blueberry muffin rash in a child with congenital rubella syndrome and communicating hydrocephalus was made based on clinical and laboratory findings. The rash disappeared by 10th day of life. © 2009 IOS Press. All rights reserved.PublicationReview Blood gas targets(National Neonatology Forum, 2009) Ashok Kumar; Sriparna BasuBlood gas measurements i.e. measurement of the levels of oxygen and carbon dioxide in arterial blood, are important parameters for critical care of sick newborns. Oxygen is one of the most commonly used as well as misused drugs in the neonatal intensive care units. Rapidly changing physiology, difficulty in access to arterial sampling sites, and small blood volumes in newborns at times present unique challenges to the treating neonatologist. Studies have shown that the use of supplemental oxygen in neonatal care may result in both significant health care benefits and harms; till date uncertainty remains as to the most appropriate range to target blood oxygen levels in preterm and low birth weight infants. Unnecessary use of oxygen in newborn babies leads to oxidative stress and damage to various organ-systems, particularly lungs, brain and eyes. Preterm newborns are most vulnerable to the toxic effects of oxygen due to their limited antioxidant defenses. There are numerous causes of hypoxia in newborns but there is only one cause of hyperoxia, namely, giving too much oxygen than what is really needed (iatrogenic). It is essential that all health professionals looking after newborn babies are sensitized to the dangers posed by hyperoxia and change their clinical practice to limit oxygen exposure in this vulnerable population.PublicationArticle Characterization of novel plant growth promoting endophytic bacterium Achromobacter xylosoxidans from wheat plant(2009) Prabhat Jha; Ashok KumarNine diazotrophic bacteria were isolated from surface-sterilized roots and culms of wheat variety Malviya-234, which is grown with very low or no inputs of nitrogen fertilizer. Out of the nine bacteria, four showed indole acetic acid (IAA) production, and five were positive for P solubilization. One isolate, WM234C-3, showed appreciable level of nitrogenase activity, IAA production, and P solubilization ability, and was further characterized with a view to exploiting its plant growth promoting activity. Based on 16S rDNA sequence analysis, this isolate was identified as Achromobacter xylosoxidans. Diazotrophic nature of this particular isolate was confirmed by Western blot analysis of dinitrogenase reductase and amplification of nifH. Analysis of the nifH sequence showed close homology with typical diazotrophic bacteria. Endophytic nature and cross-infection ability of WM234C-3 were tested by molecular tagging with gusA fused to a constitutive promoter followed by inoculation onto rice seedlings in axenic conditions. At 21 days after inoculation, the roots showed blue staining, the most intense color being at the emergence of lateral roots and root tips. Microscopic observation confirmed colonization of gus-tagged WM234C-3 in the intercellular spaces of cortical as well as vascular zones of roots. Inoculation of gus-tagged WM234C-3 to rice plants resulted in significant increase in root/shoot length, fresh weight, and chlorophyll a content. Plant growth promoting features coupled with cross-infection ability suggest that this endophytic bacterium may be exploited as agricultural agent for various crops after a thorough and critical pathogenicity test. © Springer Science+Business Media, LLC 2009.PublicationArticle An unusual cause of meconium peritonitis in a foetus: INSTRUCTIVE CASE(2009) Sriparna Basu; Ashok Kumar; Nisha PandeyMeconium peritonitis is a sterile chemical peritonitis resulting from intestinal perforation in-utero. We present a preterm male neonate weighing 1820 g in whom foetal meconium peritonitis was diagnosed by antenatal utrasonogram. Examination of the newborn in the immediate postnatal period revealed a firm lump of size 5 × 3 cm in the right lumbar and umbilical area. Rest of the abdomen was normal without any clinical evidence of intestinal obstruction. X-ray of abdomen done at 3 hours of life showed a cystic mass with calcified margin. Ultrasonography of abdomen ruled out any definite cause of intestinal obstruction and perforation. He was kept on conservative management. At 11 hours of life the neonate passed a small sticky white mucus plug per rectum followed by black colored meconium of normal consistency 2 hours later. The bowel habit remained regular thereafter. Screening for intrauterine infections and cystic fibrosis was negative. He is under regular follow-up and is now 6 months old with normal bowel habit. A lump of size 2 × 2 cm is still palpable and a small calcified mass is persistent in x-ray. Role of an intestinal mucus plug as the potential factor for intestinal obstruction and subsequent perforation has been highlighted in the present case. © 2009 Paediatrics and Child Health Division (Royal Australasian College of Physicians).PublicationArticle Hair-on-end appearance in radiograph of skull and facial bones in a case of beta thalassaemia: Images in haematology(2009) Sriparna Basu; Ashok Kumar[No abstract available]PublicationLetter Acute dyskinesia and extrapyramidal disorder in a child after ingestion of escitalopram(2009) Sunil Muthusami; Sriparna Basu; Ashok Kumar; Amitabh Dash[No abstract available]PublicationEditorial PublicationLetter Accidental aspiration of barium sulphate in an infant(2009) Sriparna Basu; Ashok Kumar; Braja K. Das[No abstract available]PublicationArticle Ultrasound enhanced sanitizer efficacy in reduction of escherichia coli o157:h7 population on spinach leaves(2009) Priyanka Singh; Ashok Kumar; Nawal K. Dubey; Rajesh GuptaThe use of ultrasound to enhance the efficacy of selected sanitizers in reduction of Escherichia coli O157 :H7 populations on spinach was investigated. Spot-inoculated spinach samples were treated with water, chlorine, acidified sodium chlorite (ASC), peroxyacetic acid (POAA), and acidic electrolyzed water with and without ultrasound (21.2 kHz) for 2 min at room temperature. The effects of ultrasound treatment time and acoustic energy density (AED)were evaluated at an ASC concentration of 200 mg/L. The effect of ASC concentration,with a fixed AEDof 200 W/L, was also examined.Microbial analysis indicated that ASC reduced E. coli O157 :H7 population by 2.2 log cycles over that of water wash, while the reduction from other sanitizers was about 1 log cycle. Ultrasonication significantly enhanced the reduction of E. coli cells on spinach for all treatments by 0.7 to 1.1 log cycle over that of washes with sanitizer alone. An increase in the ASC concentration enhanced the efficacy of the combined treatment of ASC and ultrasonication, especially at ASC concentrations of < 300 mg/L. Increasing the ultrasound treatment time from 0 to 4 min and AED from 0 to 500 W/L were both effective in increasing the effectiveness of the ASC and ultrasound combined treatments. In addition, E. coli O157 :H7 inoculated on the underside of spinach leaves (rough side) weremore difficult to remove than those inoculated on the upper side (smooth side). © 2009 Institute of Food Technologists.