2009
Permanent URI for this collectionhttps://dl.bhu.ac.in/bhuir/handle/123456789/18515
Browse
Search Results
Now showing 1 - 10 of 14
PublicationLetter Pulse therapy for pemphigus: The burden of proof(2009) Sanjay Singh; Rahul Chaudhary[No abstract available]PublicationArticle A case of Actinomycotic mycetoma involving the right foot(Journal of Infection in Developing Countries, 2009) Ragini Tilak; Sanjay Singh; Atul Garg; Jaya Bassi; Vijai Tilak; Anil K. GulatiA 45-year-old male presented with history of multiple swellings over the foot with sinuses discharging seropurulent pus. Actinomadura madurae was demonstrated and identified by microbiological culture from the pus obtained directly of the lesion. This case is reported to emphasize the importance of laboratory diagnosis in the management and assessment of the prognosis of such cases.PublicationLetter Scientific precision in titles of research papers published in three dermatology journals(2009) Sanjay Singh; Rahul Chaudhary; Swastika Suvirya[No abstract available]PublicationArticle Development and biopharmaceutical evaluation of extended release formulation of tramadol hydrochloride based on osmotic technology(Croatian Pharmaceutical Society, 2009) Pramod Kumar; Sanjay Singh; Brahmeshwar MishraExtended release formulation of tramadol hydrochloride (TRH) based on osmotic technology was developed and evaluated. Target release profile was selected and different variables were optimized to achieve it. Formulation variables such as the level of swellable polymer, plasticizer and the coat thickness of semipermeable membrane (SPM) were found to markedly affect drug release. TRH release was directly proportional to the levels of plasticizer but inversely proportional to the levels of swellable polymer and coat thickness of SPM. Drug release from developed formulations was independent of pH and agitation intensity but dependent on osmotic pressure of the release media. In vivo study was also performed on six healthy human volunteers and various pharmacokinetic parameters (cmax, tmax, AUC 0-24, MRT) and relative bioavailability were calculated. The in vitro and in vivo results were compared with the performance of two commercial TRH tablets. The developed formulation provided more prolonged and controlled TRH release compared to the marketed formulation. In vitro-in vivo correlation (IVIVC) was analyzed according to the Wagner-Nelson method. The optimized formulation (batch IVB) exhibited good IVIV correlation (R = 0.9750). The manufacturing procedure was found to be reproducible and formulations were stable over 6 months of accelerated stability testing.PublicationShort Survey PublicationArticle Metabolic drift as internal defense against drought in crop plants: Evidence unlocked from rice cultivars(2009) Sanjay Singh; T.N. Singh; J.S. ChauhanWe chose three rice (Oryza sativa L.) cultivars to understand the physiology of crop adaptation to drought. Under water stress, leaves curled up and rolled in and the water potential declined. 'Baranideep' maintained relatively higher water potential (-1.8 MPa) than irrigated hybrid rice cv. 'NDRH-2' (-2.0 MPa) and aquatic cv. 'Jal Lahri' (-2.6 MPa). The drought-induced stress caused variation in tissue-specific expressions of metabolic drift in sugar and starch, protein, and nitrogen, and stay-green traits. The genotypic differences in sugar levels varied to the extent of 130 mg g-1 fresh wt (f.w.) in 'Jal Lahri' >120 mg in 'NDRH-2' 114> mg in 'Baranideep', while initial starch contents were 263 mg >252 mg >230 mg in these cultivars, respectively. Sugar levels rose by 23% in cv. 'Jal Lahri', 16% in 'NDRH-2' and 17% in cv. 'Baranideep', whereas starch contents declined by 17%, 13% and 12.5%, respectively. The net chlorophyll concentrations were highest in 'NDRH-2' (up to 1,325 μg g-1 f.w.), followed by 'Jal Lahri' (1,050 μg) and 'Baranideep' (920 μg) under normal conditions, but declined during water stress; 'NDRH-2' maintained its superiority over the other varieties. Under water stress, chlorophyll a:b ratios increased appreciably in 'Baranideep'; 'Jal Lahri' registered the largest difference between watered and stressed plants. 'Baranideep' accumulated the largest amount of proline (9.25 mg g-1 dry wt) during water stress. Under non-stress conditions, 'NDRH-2' had the highest nitrogen content in leaves (2.15%), followed by 'Jal Lahri' (1.85%) and 'Baranideep' (1.75%). The cv. 'NDRH-2' retained more nitrogen in leaves than other cultivars. 'Jal Lahri' retained the highest nitrogen in the shoot. Nevertheless, under drought stress, the shoot protein was highest in 'NDRH-2' (3.15%), followed by 'Baranideep' (2.80%) and 'Jal Lahri' (2.65%). These tissue-specific metabolic drifts are plant's life-support system and serve as a defense against drought.PublicationReview Targeted nanomedicines: Effective treatment modalities for cancer, AIDS and brain disorders(2009) Madaswamy S. Muthu; Sanjay SinghNovel technology in the nanomedicine field is expected to develop innovative products as targeted drug-delivery approaches. Targeted drug delivery of various drugs for the treatment of cancer, AIDS and brain disorders is the primary research area in which nanomedicines have a major role and need. This review is concerned with emerging targeted nanomedicines (polymeric nanoparticles, solid lipid nanoparticles, polymeric micelles, dendrimers, liposomes, gold nanoparticles and magnetic nanoparticles) and multifunctional carriers capable of combining targeted drug delivery and imaging (polymeric micelles, dendrimers and magnetic nanoparticles) in the field of pharmaceutical applications. The significant toxicity issues associated with these nanomedicines are also explored here.PublicationReview Lipid - An emerging platform for oral delivery of drugs with poor bioavailability(2009) Subhashis Chakraborty; Dali Shukla; Brahmeshwar Mishra; Sanjay SinghThe sole objective of pharmaceutical science is to design successful dosage forms which fulfill the therapeutic needs of the patients effectively. Development of new drug entities is posing real challenge to formulators, particularly due to their poor aqueous solubility which in turn is also a major factor responsible for their poor oral bioavailability. Lipids as carriers, in their various forms, have the potential of providing endless opportunities in the area of drug delivery due to their ability to enhance gastrointestinal solubilization and absorption via selective lymphatic uptake of poorly bioavailable drugs. These properties can be harvested to improve the therapeutic efficacy of the drugs with low bioavailability, as well as to reduce their effective dose requirement. The present communication embodies an in-depth discussion on the role of lipids (both endogenous and exogenous) in bioavailability enhancement of poorly soluble drugs, mechanisms involved therein, approaches in the design of lipid-based oral drug delivery systems with particular emphasis on solid dosage forms, understanding of morphological characteristics of lipids upon digestion, in vitro lipid digestion models, in vivo studies and in vitro-in vivo correlation. © 2009 Elsevier B.V. All rights reserved.PublicationLetter A case report of tinea nigra from North India(2009) Ragini Tilak; Sanjay Singh; Pradyot Prakash; Dharmendra Singh; Anil Gulati[No abstract available]PublicationReview Stimulus-responsive targeted nanomicelles for effective cancer therapy(2009) Madaswamy S. Muthu; Chellappa V. Rajesh; Amit Mishra; Sanjay SinghEmerging nanotechnology has already developed various innovative nanomedicines. Nanomicelles, self-assemblies of block copolymers, are promising nanomedicines for targeted drug delivery and imaging. Stimulus-responsive targeted nanomicelles are designed to release drugs based on stimuli such as pH, temperature, redox potential, magnetism and ultrasound. This article will focus on recent advancements in the design of stimulus-responsive targeted nanomicelles loaded with anticancer drugs to fulfill the challenges associated with cancer cells (e.g., multidrug resistance) for the effective treatment of cancer. The significant toxicity issues and a possible future perspective associated with nanomicelles are also discussed here. © 2009 Future Medicine Ltd.